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The TSH response to domperidone reflects the biological activity of prolactin in macroprolactinaemia and hyperprolactinaemia.
Clin Endocrinol (Oxf). 2003 Nov; 59(5):580-4.CE

Abstract

OBJECTIVE

To test the hypothesis that patients with hyperprolactinaemia due to biologically inactive macroprolactin will not show the characteristically increased dopaminergic inhibition of TSH release seen in patients with microprolactinomas secreting biologically active monomeric PRL.

DESIGN

Comparison of the TSH and PRL responses to dopamine antagonism with domperidone (10 mg i.v.) in patients with hyperprolactinaemia due to macroprolactinaemia or microprolactinomas.

PATIENTS

Twenty-two patients referred for the investigation of their hyperprolactinaemia were studied: 11 patients with macroprolactinaemia and 11 patients with hyperprolactinaemia due to microprolactinoma.

MEASUREMENTS

TSH and PRL levels were measured at baseline and 30 min following domperidone in both groups.

RESULTS

Patients with macroprolactinaemia showed normal TSH and PRL responses to dopamine antagonism whereas patients with microprolactinomas showed exaggerated TSH responses and reduced PRL responses. Although there was considerable overlap between the PRL responses in the two groups, there was very clear separation between the PRL/TSH response ratios (normal > 1.0) of 4.0 +/- 1.8 for the macroprolactinaemia group and 0.4 +/- 0.2 for the microprolactinoma group (P < 0.0001).

CONCLUSIONS

These data support the hypothesis that elevated circulating levels of macroprolactin, as opposed to biologically active monomeric PRL, do not exert increased positive feedback on the hypothalamic dopaminergic inhibition of TSH release.

Authors+Show Affiliations

Department of Endocrinology, University Hospital of Wales, Heath Park, Cardiff, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

14616880

Citation

Pinto, L P., et al. "The TSH Response to Domperidone Reflects the Biological Activity of Prolactin in Macroprolactinaemia and Hyperprolactinaemia." Clinical Endocrinology, vol. 59, no. 5, 2003, pp. 580-4.
Pinto LP, Hanna FW, Evans LM, et al. The TSH response to domperidone reflects the biological activity of prolactin in macroprolactinaemia and hyperprolactinaemia. Clin Endocrinol (Oxf). 2003;59(5):580-4.
Pinto, L. P., Hanna, F. W., Evans, L. M., Davies, J. S., John, R., & Scanlon, M. F. (2003). The TSH response to domperidone reflects the biological activity of prolactin in macroprolactinaemia and hyperprolactinaemia. Clinical Endocrinology, 59(5), 580-4.
Pinto LP, et al. The TSH Response to Domperidone Reflects the Biological Activity of Prolactin in Macroprolactinaemia and Hyperprolactinaemia. Clin Endocrinol (Oxf). 2003;59(5):580-4. PubMed PMID: 14616880.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The TSH response to domperidone reflects the biological activity of prolactin in macroprolactinaemia and hyperprolactinaemia. AU - Pinto,L P, AU - Hanna,F W F, AU - Evans,L M, AU - Davies,J S, AU - John,R, AU - Scanlon,M F, PY - 2003/11/18/pubmed PY - 2004/2/6/medline PY - 2003/11/18/entrez SP - 580 EP - 4 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 59 IS - 5 N2 - OBJECTIVE: To test the hypothesis that patients with hyperprolactinaemia due to biologically inactive macroprolactin will not show the characteristically increased dopaminergic inhibition of TSH release seen in patients with microprolactinomas secreting biologically active monomeric PRL. DESIGN: Comparison of the TSH and PRL responses to dopamine antagonism with domperidone (10 mg i.v.) in patients with hyperprolactinaemia due to macroprolactinaemia or microprolactinomas. PATIENTS: Twenty-two patients referred for the investigation of their hyperprolactinaemia were studied: 11 patients with macroprolactinaemia and 11 patients with hyperprolactinaemia due to microprolactinoma. MEASUREMENTS: TSH and PRL levels were measured at baseline and 30 min following domperidone in both groups. RESULTS: Patients with macroprolactinaemia showed normal TSH and PRL responses to dopamine antagonism whereas patients with microprolactinomas showed exaggerated TSH responses and reduced PRL responses. Although there was considerable overlap between the PRL responses in the two groups, there was very clear separation between the PRL/TSH response ratios (normal > 1.0) of 4.0 +/- 1.8 for the macroprolactinaemia group and 0.4 +/- 0.2 for the microprolactinoma group (P < 0.0001). CONCLUSIONS: These data support the hypothesis that elevated circulating levels of macroprolactin, as opposed to biologically active monomeric PRL, do not exert increased positive feedback on the hypothalamic dopaminergic inhibition of TSH release. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/14616880/The_TSH_response_to_domperidone_reflects_the_biological_activity_of_prolactin_in_macroprolactinaemia_and_hyperprolactinaemia_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0300-0664&amp;date=2003&amp;volume=59&amp;issue=5&amp;spage=580 DB - PRIME DP - Unbound Medicine ER -