Tags

Type your tag names separated by a space and hit enter

Ghrelin concentrations in healthy children and adolescents.

Abstract

OBJECTIVE

In addition to its regulation by GH releasing hormone (GHRH) and somatostatin, release of GH from the pituitary is modulated by a third factor, ghrelin, which is expressed in high concentration in the stomach and is present in the circulation. Ghrelin has also been shown to cause weight gain by increasing food intake and decreasing fat utilization. Ghrelin is a potential candidate hormone to influence nutrient intake and growth. Its role through normal childhood and adolescence has not been fully defined.

DESIGN

Cross-sectional study in 121 healthy children (65 male, 56 female) aged 5-18 years, in whom height, weight, body mass index (BMI), pubertal status and measurements of IGF-I, IGFBP-3, IGFBP-1 and leptin were available.

METHODS

Serum ghrelin concentrations have been measured in radioimmunoassay (RIA; Phoenix, AZ, USA) that detects active and inactive human ghrelin. Relationships between ghrelin and anthropometric data and growth factors were assessed by correlation and regression analyses.

RESULTS

Ghrelin was detected in all samples, with a median concentration of 162 pg/ml, range 60-493 pg/ml. Prepubertal children had higher ghrelin concentrations than those in puberty [218 pg/ml (n = 42) and 157 pg/ml (n = 79), P < 0.001], with significant negative correlations between ghrelin and age (rs = -0.39, P < 0.001) and pubertal stage (rs = -0.42, P < 0.001). The decrease in ghrelin with advancing pubertal stage/age was more marked in boys than girls. In the whole group, ghrelin was negatively correlated to BMI SD (rs = -0.24, P = 0.006) and to weight SD (rs = -0.24, P = 0.008) but not height sds. Ghrelin was also negatively correlated to IGF-I (rs = -0.48, P < 0.001), IGFBP-3 (rs = -0.32, P < 0.001) and leptin (rs = -0.22, P = 0.02) but not IGF-II. It was positively related to IGFBP-1 (rs = +0.46, P < 0.001). In stepwise multiple regression, 30% of the variability in ghrelin through childhood could be accounted for by log IGF-I (24%) and log IGFBP-1 (6%).

CONCLUSIONS

The fall in ghrelin over childhood and with puberty does not suggest that it is a direct growth-promoting hormone. However in view of the negative relationship with IGF-I and the positive relationship with IGFBP-1, this fall in ghrelin could facilitate growth acceleration over puberty.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Endocrine Science Research Group, University of Manchester, UK.

    , , ,

    Source

    Clinical endocrinology 59:5 2003 Nov pg 649-54

    MeSH

    Adolescent
    Adult
    Age Factors
    Body Mass Index
    Body Weight
    Child
    Child, Preschool
    Cross-Sectional Studies
    Female
    Ghrelin
    Humans
    Insulin-Like Growth Factor Binding Protein 1
    Insulin-Like Growth Factor Binding Protein 3
    Insulin-Like Growth Factor I
    Leptin
    Linear Models
    Male
    Peptide Hormones
    Puberty
    Sex Factors
    Statistics, Nonparametric

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    14616891

    Citation

    Whatmore, A J., et al. "Ghrelin Concentrations in Healthy Children and Adolescents." Clinical Endocrinology, vol. 59, no. 5, 2003, pp. 649-54.
    Whatmore AJ, Hall CM, Jones J, et al. Ghrelin concentrations in healthy children and adolescents. Clin Endocrinol (Oxf). 2003;59(5):649-54.
    Whatmore, A. J., Hall, C. M., Jones, J., Westwood, M., & Clayton, P. E. (2003). Ghrelin concentrations in healthy children and adolescents. Clinical Endocrinology, 59(5), pp. 649-54.
    Whatmore AJ, et al. Ghrelin Concentrations in Healthy Children and Adolescents. Clin Endocrinol (Oxf). 2003;59(5):649-54. PubMed PMID: 14616891.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Ghrelin concentrations in healthy children and adolescents. AU - Whatmore,A J, AU - Hall,C M, AU - Jones,J, AU - Westwood,M, AU - Clayton,P E, PY - 2003/11/18/pubmed PY - 2004/2/6/medline PY - 2003/11/18/entrez SP - 649 EP - 54 JF - Clinical endocrinology JO - Clin. Endocrinol. (Oxf) VL - 59 IS - 5 N2 - OBJECTIVE: In addition to its regulation by GH releasing hormone (GHRH) and somatostatin, release of GH from the pituitary is modulated by a third factor, ghrelin, which is expressed in high concentration in the stomach and is present in the circulation. Ghrelin has also been shown to cause weight gain by increasing food intake and decreasing fat utilization. Ghrelin is a potential candidate hormone to influence nutrient intake and growth. Its role through normal childhood and adolescence has not been fully defined. DESIGN: Cross-sectional study in 121 healthy children (65 male, 56 female) aged 5-18 years, in whom height, weight, body mass index (BMI), pubertal status and measurements of IGF-I, IGFBP-3, IGFBP-1 and leptin were available. METHODS: Serum ghrelin concentrations have been measured in radioimmunoassay (RIA; Phoenix, AZ, USA) that detects active and inactive human ghrelin. Relationships between ghrelin and anthropometric data and growth factors were assessed by correlation and regression analyses. RESULTS: Ghrelin was detected in all samples, with a median concentration of 162 pg/ml, range 60-493 pg/ml. Prepubertal children had higher ghrelin concentrations than those in puberty [218 pg/ml (n = 42) and 157 pg/ml (n = 79), P < 0.001], with significant negative correlations between ghrelin and age (rs = -0.39, P < 0.001) and pubertal stage (rs = -0.42, P < 0.001). The decrease in ghrelin with advancing pubertal stage/age was more marked in boys than girls. In the whole group, ghrelin was negatively correlated to BMI SD (rs = -0.24, P = 0.006) and to weight SD (rs = -0.24, P = 0.008) but not height sds. Ghrelin was also negatively correlated to IGF-I (rs = -0.48, P < 0.001), IGFBP-3 (rs = -0.32, P < 0.001) and leptin (rs = -0.22, P = 0.02) but not IGF-II. It was positively related to IGFBP-1 (rs = +0.46, P < 0.001). In stepwise multiple regression, 30% of the variability in ghrelin through childhood could be accounted for by log IGF-I (24%) and log IGFBP-1 (6%). CONCLUSIONS: The fall in ghrelin over childhood and with puberty does not suggest that it is a direct growth-promoting hormone. However in view of the negative relationship with IGF-I and the positive relationship with IGFBP-1, this fall in ghrelin could facilitate growth acceleration over puberty. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/14616891/Ghrelin_concentrations_in_healthy_children_and_adolescents_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0300-0664&amp;date=2003&amp;volume=59&amp;issue=5&amp;spage=649 DB - PRIME DP - Unbound Medicine ER -