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Eating pattern and the effect of oral glucose on ghrelin and insulin secretion in patients with anorexia nervosa.
Clin Endocrinol (Oxf). 2003 Nov; 59(5):574-9.CE

Abstract

OBJECTIVE

Ghrelin is thought to be involved in the regulation of eating behaviour and energy metabolism in acute and chronic feeding states. Circulating plasma ghrelin levels in healthy humans have been found to decrease significantly after oral glucose administration. Because it is suggested that eating behaviour may influence the secretion of ghrelin and insulin in anorexia nervosa (AN), we examined the effect of oral glucose on ghrelin and insulin secretion in subtypes of AN patients.

DESIGN AND PATIENTS

Twenty female AN patients and 10 age-matched female controls were subjects. The patients were subdivided into two subtypes based on eating behaviour as follows: 11 restricting type (AN-R), nine binge-eating and purging type (AN-BP). Subjects underwent an oral glucose tolerance test at 08.00 h. Blood was collected 0, 30, 60, 120 and 180 min after the glucose load.

RESULTS

Both AN-R and AN-BP had a significant increased basal ghrelin level (P < 0.01) and a significantly decreased basal insulin level (P < 0.05) as compared to controls. The time of the nadir of mean ghrelin in AN-BP (120 min, 58.1% of basal level, 204.9 +/- 34.3 pmol/l, mean +/- SEM) was delayed compared to controls (60 min, 60.2%, 74.3 +/- 7.9 pmol/l), and in the AN-R group it kept decreasing for 180 min (80.0%, 182.4 +/- 31.5 pmol/l). The peaks insulin levels in AN-BP (120 min, 319.3 +/- 88.8 pmol/l) and AN-R (180 min, 418.9 +/- 68.4 pmol/l) were also delayed as compared to controls (60 min, 509.2 +/- 88.8 pmol/l). The glucose level at 180 min in AN-R was significantly (P < 0.05) higher than in controls.

CONCLUSIONS

These findings suggest that differences in eating behaviour in AN may induce alterations in both ghrelin and insulin metabolism in the acute feeding state. Furthermore, metabolic changes in the restrictive eating pattern may be related to the pathophysiology of small quantitative meal intake in AN-R patients.

Authors+Show Affiliations

Department of Psychosomatic Medicine, Kagoshima University Hospital, Faculty of Medicine, Kagoshima University, Sakuragaoka, Kagoshima, Japan. muneki@m3.kufm.kagoshima-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14616897

Citation

Tanaka, Muneki, et al. "Eating Pattern and the Effect of Oral Glucose On Ghrelin and Insulin Secretion in Patients With Anorexia Nervosa." Clinical Endocrinology, vol. 59, no. 5, 2003, pp. 574-9.
Tanaka M, Tatebe Y, Nakahara T, et al. Eating pattern and the effect of oral glucose on ghrelin and insulin secretion in patients with anorexia nervosa. Clin Endocrinol (Oxf). 2003;59(5):574-9.
Tanaka, M., Tatebe, Y., Nakahara, T., Yasuhara, D., Sagiyama, K., Muranaga, T., Ueno, H., Nakazato, M., Nozoe, S., & Naruo, T. (2003). Eating pattern and the effect of oral glucose on ghrelin and insulin secretion in patients with anorexia nervosa. Clinical Endocrinology, 59(5), 574-9.
Tanaka M, et al. Eating Pattern and the Effect of Oral Glucose On Ghrelin and Insulin Secretion in Patients With Anorexia Nervosa. Clin Endocrinol (Oxf). 2003;59(5):574-9. PubMed PMID: 14616897.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eating pattern and the effect of oral glucose on ghrelin and insulin secretion in patients with anorexia nervosa. AU - Tanaka,Muneki, AU - Tatebe,Yoshiki, AU - Nakahara,Toshihiro, AU - Yasuhara,Daisuke, AU - Sagiyama,Ken-ichiro, AU - Muranaga,Tetsuro, AU - Ueno,Hiroaki, AU - Nakazato,Masamitsu, AU - Nozoe,Shin-ichi, AU - Naruo,Tetsuro, PY - 2003/11/18/pubmed PY - 2004/2/6/medline PY - 2003/11/18/entrez SP - 574 EP - 9 JF - Clinical endocrinology JO - Clin. Endocrinol. (Oxf) VL - 59 IS - 5 N2 - OBJECTIVE: Ghrelin is thought to be involved in the regulation of eating behaviour and energy metabolism in acute and chronic feeding states. Circulating plasma ghrelin levels in healthy humans have been found to decrease significantly after oral glucose administration. Because it is suggested that eating behaviour may influence the secretion of ghrelin and insulin in anorexia nervosa (AN), we examined the effect of oral glucose on ghrelin and insulin secretion in subtypes of AN patients. DESIGN AND PATIENTS: Twenty female AN patients and 10 age-matched female controls were subjects. The patients were subdivided into two subtypes based on eating behaviour as follows: 11 restricting type (AN-R), nine binge-eating and purging type (AN-BP). Subjects underwent an oral glucose tolerance test at 08.00 h. Blood was collected 0, 30, 60, 120 and 180 min after the glucose load. RESULTS: Both AN-R and AN-BP had a significant increased basal ghrelin level (P < 0.01) and a significantly decreased basal insulin level (P < 0.05) as compared to controls. The time of the nadir of mean ghrelin in AN-BP (120 min, 58.1% of basal level, 204.9 +/- 34.3 pmol/l, mean +/- SEM) was delayed compared to controls (60 min, 60.2%, 74.3 +/- 7.9 pmol/l), and in the AN-R group it kept decreasing for 180 min (80.0%, 182.4 +/- 31.5 pmol/l). The peaks insulin levels in AN-BP (120 min, 319.3 +/- 88.8 pmol/l) and AN-R (180 min, 418.9 +/- 68.4 pmol/l) were also delayed as compared to controls (60 min, 509.2 +/- 88.8 pmol/l). The glucose level at 180 min in AN-R was significantly (P < 0.05) higher than in controls. CONCLUSIONS: These findings suggest that differences in eating behaviour in AN may induce alterations in both ghrelin and insulin metabolism in the acute feeding state. Furthermore, metabolic changes in the restrictive eating pattern may be related to the pathophysiology of small quantitative meal intake in AN-R patients. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/14616897/Eating_pattern_and_the_effect_of_oral_glucose_on_ghrelin_and_insulin_secretion_in_patients_with_anorexia_nervosa_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0300-0664&amp;date=2003&amp;volume=59&amp;issue=5&amp;spage=574 DB - PRIME DP - Unbound Medicine ER -