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Edrophonium effectively antagonizes neuromuscular block at the laryngeal adductors induced by rapacuronium, rocuronium and cisatracurium, but not mivacurium.
Can J Anaesth. 2003 Nov; 50(9):879-85.CJ

Abstract

PURPOSE

To examine the efficacy of antagonism of rapacuronium-, mivacurium-, rocuronium- and cisatracurium-induced neuromuscular block at the laryngeal adductors (LA).

METHODS

One hundred four patients were randomly assigned to one of eight study groups. They either received rapacuronium 1.5 mg x kg(-1), mivacurium 0.25 mg x kg(-1), rocuronium 0.9 mg x kg(-1) or cisatracurium 0.15 mg x kg(-1). Patients in each treatment group either received edrophonium (0.5 mg x kg(-1)) at 10% recovery of the first twitch (T1) of train-of-four (TOF) at the LA or were allowed to recover spontaneously from neuromuscular block. The effect of antagonism on speed of recovery of neuromuscular function at the LA was evaluated.

RESULTS

The time to recovery to a TOF ratio of 0.9 at the LA, when compared to the spontaneous recovery group, was significantly shortened by the administration of edrophonium in patients receiving rapacuronium [19.2 +/- 7.8 vs 26.2 +/- 4.9 (mean +/- SD) min], rocuronium (24.7 +/- 14.3 vs 44.4 +/- 13.0 min) and cisatracurium (24.2 +/- 5.7 vs 35.1 +/- 7.6 min). Edrophonium administration did not shorten complete recovery from mivacurium-induced block (15.7 +/- 8.0 vs 17.6 +/- 6.1 min).

CONCLUSION

Recovery from rapacuronium-, rocuronium- or cisatracurium- induced neuromuscular block to a TOF ratio of 0.9 as measured at the LA was shortened by the administration of edrophonium, when compared to spontaneous recovery.

Authors+Show Affiliations

Department of Anesthesiology, New York Presbyterian Hospital-Weill Medical College of Cornell University, New York, New York, USA. suzukit@cd5.so-net.ne.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14617582

Citation

Suzuki, Takahiro, et al. "Edrophonium Effectively Antagonizes Neuromuscular Block at the Laryngeal Adductors Induced By Rapacuronium, Rocuronium and Cisatracurium, but Not Mivacurium." Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie, vol. 50, no. 9, 2003, pp. 879-85.
Suzuki T, Lien CA, Belmont MR, et al. Edrophonium effectively antagonizes neuromuscular block at the laryngeal adductors induced by rapacuronium, rocuronium and cisatracurium, but not mivacurium. Can J Anaesth. 2003;50(9):879-85.
Suzuki, T., Lien, C. A., Belmont, M. R., Tjan, J., & Savarese, J. J. (2003). Edrophonium effectively antagonizes neuromuscular block at the laryngeal adductors induced by rapacuronium, rocuronium and cisatracurium, but not mivacurium. Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie, 50(9), 879-85.
Suzuki T, et al. Edrophonium Effectively Antagonizes Neuromuscular Block at the Laryngeal Adductors Induced By Rapacuronium, Rocuronium and Cisatracurium, but Not Mivacurium. Can J Anaesth. 2003;50(9):879-85. PubMed PMID: 14617582.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Edrophonium effectively antagonizes neuromuscular block at the laryngeal adductors induced by rapacuronium, rocuronium and cisatracurium, but not mivacurium. AU - Suzuki,Takahiro, AU - Lien,Cynthia A, AU - Belmont,Matthew R, AU - Tjan,Joseph, AU - Savarese,John J, PY - 2003/11/18/pubmed PY - 2004/5/11/medline PY - 2003/11/18/entrez SP - 879 EP - 85 JF - Canadian journal of anaesthesia = Journal canadien d'anesthesie JO - Can J Anaesth VL - 50 IS - 9 N2 - PURPOSE: To examine the efficacy of antagonism of rapacuronium-, mivacurium-, rocuronium- and cisatracurium-induced neuromuscular block at the laryngeal adductors (LA). METHODS: One hundred four patients were randomly assigned to one of eight study groups. They either received rapacuronium 1.5 mg x kg(-1), mivacurium 0.25 mg x kg(-1), rocuronium 0.9 mg x kg(-1) or cisatracurium 0.15 mg x kg(-1). Patients in each treatment group either received edrophonium (0.5 mg x kg(-1)) at 10% recovery of the first twitch (T1) of train-of-four (TOF) at the LA or were allowed to recover spontaneously from neuromuscular block. The effect of antagonism on speed of recovery of neuromuscular function at the LA was evaluated. RESULTS: The time to recovery to a TOF ratio of 0.9 at the LA, when compared to the spontaneous recovery group, was significantly shortened by the administration of edrophonium in patients receiving rapacuronium [19.2 +/- 7.8 vs 26.2 +/- 4.9 (mean +/- SD) min], rocuronium (24.7 +/- 14.3 vs 44.4 +/- 13.0 min) and cisatracurium (24.2 +/- 5.7 vs 35.1 +/- 7.6 min). Edrophonium administration did not shorten complete recovery from mivacurium-induced block (15.7 +/- 8.0 vs 17.6 +/- 6.1 min). CONCLUSION: Recovery from rapacuronium-, rocuronium- or cisatracurium- induced neuromuscular block to a TOF ratio of 0.9 as measured at the LA was shortened by the administration of edrophonium, when compared to spontaneous recovery. SN - 0832-610X UR - https://www.unboundmedicine.com/medline/citation/14617582/Edrophonium_effectively_antagonizes_neuromuscular_block_at_the_laryngeal_adductors_induced_by_rapacuronium_rocuronium_and_cisatracurium_but_not_mivacurium_ L2 - https://doi.org/10.1007/BF03018732 DB - PRIME DP - Unbound Medicine ER -