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[Compressibility of directly compressed forms of lactitol].
Ceska Slov Farm. 2003 Sep; 52(5):241-3.CS

Abstract

Lactitol ranks among sugar alcohols which are employed as dry binders in the manufacture of tablets, particularly the chewable ones. Water-granulated lactitol is the directly compacting form of this substance. The present paper studies the compressibility of the granulated form of lactitol and the effects of different concentrations of the lubricant magnesium stearate on the strength and disintegration time of the compacts from his substance. Lactitol cannot be compressed without an added lubricant. Magnesium stearate, employed in two concentrations, 0.4% and 0.8%, did not negatively interfere with the strength of the compacts. The disintegration period of tablets was prolonged with increasing stearate concentration, but independently of compression force.

Authors+Show Affiliations

Muzíková J
Katedra farmaceutické technologie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové. muzikova@faf.cuni.cz

MeSH

Chemistry, PharmaceuticalCompressive StrengthStearic AcidsSugar AlcoholsTablets

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

cze

PubMed ID

14619701

Citation

Muzíková, J. "[Compressibility of Directly Compressed Forms of Lactitol]." Ceska a Slovenska Farmacie : Casopis Ceske Farmaceuticke Spolecnosti a Slovenske Farmaceuticke Spolecnosti, vol. 52, no. 5, 2003, pp. 241-3.
Muzíková J. [Compressibility of directly compressed forms of lactitol]. Ceska Slov Farm. 2003;52(5):241-3.
Muzíková, J. (2003). [Compressibility of directly compressed forms of lactitol]. Ceska a Slovenska Farmacie : Casopis Ceske Farmaceuticke Spolecnosti a Slovenske Farmaceuticke Spolecnosti, 52(5), 241-3.
Muzíková J. [Compressibility of Directly Compressed Forms of Lactitol]. Ceska Slov Farm. 2003;52(5):241-3. PubMed PMID: 14619701.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Compressibility of directly compressed forms of lactitol]. A1 - Muzíková,J, PY - 2003/11/19/pubmed PY - 2004/1/21/medline PY - 2003/11/19/entrez SP - 241 EP - 3 JF - Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti JO - Ceska Slov Farm VL - 52 IS - 5 N2 - Lactitol ranks among sugar alcohols which are employed as dry binders in the manufacture of tablets, particularly the chewable ones. Water-granulated lactitol is the directly compacting form of this substance. The present paper studies the compressibility of the granulated form of lactitol and the effects of different concentrations of the lubricant magnesium stearate on the strength and disintegration time of the compacts from his substance. Lactitol cannot be compressed without an added lubricant. Magnesium stearate, employed in two concentrations, 0.4% and 0.8%, did not negatively interfere with the strength of the compacts. The disintegration period of tablets was prolonged with increasing stearate concentration, but independently of compression force. SN - 1210-7816 UR - https://www.unboundmedicine.com/medline/citation/14619701/[Compressibility_of_directly_compressed_forms_of_lactitol]_ DB - PRIME DP - Unbound Medicine ER -