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Nonspecific interstitial pneumonia in collagen vascular diseases: comparison of the clinical characteristics and prognostic significance with usual interstitial pneumonia.
Sarcoidosis Vasc Diffuse Lung Dis. 2003 Oct; 20(3):235-41.SV

Abstract

BACKGROUND

Nonspecific interstitial pneumonia (NSIP) has recently been described as a distinct clinicopathological entity among idiopathic interstitial pneumonias (IIP), having more favorable prognosis than usual interstitial pneumonia (UIP). Although NSIP was initially reported to also occur in patients with interstitial pneumonia associated with collagen vascular diseases (IP-CVD), the prevalence of NSIP and its prognostic significance in IP-CVD remains to be determined. Thus, we attempted to clarify clinical characteristics and prognostic significance of NSIP in IP-CVD.

METHODS

We histologically examined surgical lung biopsies from 43 patients with IP-CVD based on a current classification of interstitial pneumonias, and compared the clinical characteristics and prognostic significance of NSIP with UIP in IP-CVD. We also studied 98 patients with biopsy-proven NSIP and UIP in IIP, and compared the prognostic significance of histopathologic subclassification in IIP with that in IP-CVD.

RESULTS

In IP-CVD, twenty-six patients (60%) were classified as NSIP, 17 (40%) as UIP. In contrast, 76 (77%) were categorized into UIP and 22 (23%) into NSIP of the patients with IIP. No significant difference in survival rates was observed between UIP and NSIP in IP-CVD (p = 0.3863), while, in IIP, NSIP has a significant better survival than UIP (p = 0.022).

CONCLUSIONS

These results suggest that NSIP is more common histologic pattern than UIP in IP-CVD and, unlike in IIP, the prognosis of NSIP patients may not be different from that of UIP patients in IP-CVD.

Authors+Show Affiliations

Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

14620168

Citation

Nakamura, Yutaro, et al. "Nonspecific Interstitial Pneumonia in Collagen Vascular Diseases: Comparison of the Clinical Characteristics and Prognostic Significance With Usual Interstitial Pneumonia." Sarcoidosis, Vasculitis, and Diffuse Lung Diseases : Official Journal of WASOG, vol. 20, no. 3, 2003, pp. 235-41.
Nakamura Y, Chida K, Suda T, et al. Nonspecific interstitial pneumonia in collagen vascular diseases: comparison of the clinical characteristics and prognostic significance with usual interstitial pneumonia. Sarcoidosis Vasc Diffuse Lung Dis. 2003;20(3):235-41.
Nakamura, Y., Chida, K., Suda, T., Hayakawa, H., Iwata, M., Imokawa, S., Tsuchiya, T., Ida, M., Gemma, H., Yasuda, K., Yagi, T., Shirai, T., Tamura, R., Nakano, Y., Hirata, T., Nakamura, H., & Colby, T. V. (2003). Nonspecific interstitial pneumonia in collagen vascular diseases: comparison of the clinical characteristics and prognostic significance with usual interstitial pneumonia. Sarcoidosis, Vasculitis, and Diffuse Lung Diseases : Official Journal of WASOG, 20(3), 235-41.
Nakamura Y, et al. Nonspecific Interstitial Pneumonia in Collagen Vascular Diseases: Comparison of the Clinical Characteristics and Prognostic Significance With Usual Interstitial Pneumonia. Sarcoidosis Vasc Diffuse Lung Dis. 2003;20(3):235-41. PubMed PMID: 14620168.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nonspecific interstitial pneumonia in collagen vascular diseases: comparison of the clinical characteristics and prognostic significance with usual interstitial pneumonia. AU - Nakamura,Yutaro, AU - Chida,Kingo, AU - Suda,Takafimi, AU - Hayakawa,Hiroshi, AU - Iwata,Masatoshi, AU - Imokawa,Shiro, AU - Tsuchiya,Tomoyoshi, AU - Ida,Masaaki, AU - Gemma,Hitoshi, AU - Yasuda,Kazumasa, AU - Yagi,Takeshi, AU - Shirai,Toshihiro, AU - Tamura,Ryoji, AU - Nakano,Yutaka, AU - Hirata,Takeo, AU - Nakamura,Hirotoshi, AU - Colby,Thomas V, PY - 2003/11/19/pubmed PY - 2004/2/26/medline PY - 2003/11/19/entrez SP - 235 EP - 41 JF - Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG JO - Sarcoidosis Vasc Diffuse Lung Dis VL - 20 IS - 3 N2 - BACKGROUND: Nonspecific interstitial pneumonia (NSIP) has recently been described as a distinct clinicopathological entity among idiopathic interstitial pneumonias (IIP), having more favorable prognosis than usual interstitial pneumonia (UIP). Although NSIP was initially reported to also occur in patients with interstitial pneumonia associated with collagen vascular diseases (IP-CVD), the prevalence of NSIP and its prognostic significance in IP-CVD remains to be determined. Thus, we attempted to clarify clinical characteristics and prognostic significance of NSIP in IP-CVD. METHODS: We histologically examined surgical lung biopsies from 43 patients with IP-CVD based on a current classification of interstitial pneumonias, and compared the clinical characteristics and prognostic significance of NSIP with UIP in IP-CVD. We also studied 98 patients with biopsy-proven NSIP and UIP in IIP, and compared the prognostic significance of histopathologic subclassification in IIP with that in IP-CVD. RESULTS: In IP-CVD, twenty-six patients (60%) were classified as NSIP, 17 (40%) as UIP. In contrast, 76 (77%) were categorized into UIP and 22 (23%) into NSIP of the patients with IIP. No significant difference in survival rates was observed between UIP and NSIP in IP-CVD (p = 0.3863), while, in IIP, NSIP has a significant better survival than UIP (p = 0.022). CONCLUSIONS: These results suggest that NSIP is more common histologic pattern than UIP in IP-CVD and, unlike in IIP, the prognosis of NSIP patients may not be different from that of UIP patients in IP-CVD. SN - 1124-0490 UR - https://www.unboundmedicine.com/medline/citation/14620168/Nonspecific_interstitial_pneumonia_in_collagen_vascular_diseases:_comparison_of_the_clinical_characteristics_and_prognostic_significance_with_usual_interstitial_pneumonia_ L2 - http://www.diseaseinfosearch.org/result/7327 DB - PRIME DP - Unbound Medicine ER -