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Fatty acid profile of oesophageal mucosa in children with gastro-oesophageal reflux disease.
Dig Liver Dis 2003; 35(10):694-700DL

Abstract

BACKGROUND

Polyunsaturated fatty acids, as precursors of eicosanoids, are involved in the pathogenesis of oesophageal mucosal damage and healing.

AIMS

To evaluate a possible role of polyunsaturated fatty acids in the pathogenesis of gastro-oesophageal reflux, we assayed fatty acids profile of oesophageal mucosal specimens obtained by endoscopy in children without oesophageal disease and children affected by gastro-oesophageal reflux disease.

PATIENTS

Eighteen children with normal 24-h oesophageal pH monitoring (GOR- group) and 18 children with gastro-oesophageal reflux disease (GOR+ group, eight with oesophagitis and 10 without), were included in the study.

METHODS

Fatty acids were extracted from oesophageal mucosal specimens obtained by endoscopy and assayed by gas chromatography.

RESULTS

In the GOR+ group we observed an increased percentage of mucosal polyunsaturated fatty acids, mainly arachidonic and docosohexaenoic acids (p<0.01), without differences between groups with and without oesophagitis. Significant positive correlation was found between reflux index and docosahexaenoic acid (r=0.805; p<0.001).

CONCLUSIONS

The results obtained show that the current methods are able to reveal changes between normal and pathological mucosa that could be relevant in the pathogenesis of gastro-oesophageal reflux disease.

Authors+Show Affiliations

Department of Paedriatics, La Sapienza University, Viale Regina Elena, 324-00161 Rome, Italy. patdeufemia@inwind.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14620617

Citation

D'Eufemia, P, et al. "Fatty Acid Profile of Oesophageal Mucosa in Children With Gastro-oesophageal Reflux Disease." Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, vol. 35, no. 10, 2003, pp. 694-700.
D'Eufemia P, Celli M, Finocchiaro R, et al. Fatty acid profile of oesophageal mucosa in children with gastro-oesophageal reflux disease. Dig Liver Dis. 2003;35(10):694-700.
D'Eufemia, P., Celli, M., Finocchiaro, R., Troiani, P., Tote, J., Giardini, O., & Corrado, G. (2003). Fatty acid profile of oesophageal mucosa in children with gastro-oesophageal reflux disease. Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 35(10), pp. 694-700.
D'Eufemia P, et al. Fatty Acid Profile of Oesophageal Mucosa in Children With Gastro-oesophageal Reflux Disease. Dig Liver Dis. 2003;35(10):694-700. PubMed PMID: 14620617.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fatty acid profile of oesophageal mucosa in children with gastro-oesophageal reflux disease. AU - D'Eufemia,P, AU - Celli,M, AU - Finocchiaro,R, AU - Troiani,P, AU - Tote,J, AU - Giardini,O, AU - Corrado,G, PY - 2003/11/19/pubmed PY - 2004/1/30/medline PY - 2003/11/19/entrez SP - 694 EP - 700 JF - Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver JO - Dig Liver Dis VL - 35 IS - 10 N2 - BACKGROUND: Polyunsaturated fatty acids, as precursors of eicosanoids, are involved in the pathogenesis of oesophageal mucosal damage and healing. AIMS: To evaluate a possible role of polyunsaturated fatty acids in the pathogenesis of gastro-oesophageal reflux, we assayed fatty acids profile of oesophageal mucosal specimens obtained by endoscopy in children without oesophageal disease and children affected by gastro-oesophageal reflux disease. PATIENTS: Eighteen children with normal 24-h oesophageal pH monitoring (GOR- group) and 18 children with gastro-oesophageal reflux disease (GOR+ group, eight with oesophagitis and 10 without), were included in the study. METHODS: Fatty acids were extracted from oesophageal mucosal specimens obtained by endoscopy and assayed by gas chromatography. RESULTS: In the GOR+ group we observed an increased percentage of mucosal polyunsaturated fatty acids, mainly arachidonic and docosohexaenoic acids (p<0.01), without differences between groups with and without oesophagitis. Significant positive correlation was found between reflux index and docosahexaenoic acid (r=0.805; p<0.001). CONCLUSIONS: The results obtained show that the current methods are able to reveal changes between normal and pathological mucosa that could be relevant in the pathogenesis of gastro-oesophageal reflux disease. SN - 1590-8658 UR - https://www.unboundmedicine.com/medline/citation/14620617/Fatty_acid_profile_of_oesophageal_mucosa_in_children_with_gastro_oesophageal_reflux_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1590-8658(03)00411-0 DB - PRIME DP - Unbound Medicine ER -