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Gabapentin in the management of pentazocine dependence: a potent analgesic--anticraving agent.
J Assoc Physicians India. 2003 Jul; 51:673-6.JA

Abstract

OBJECTIVES

To evaluate the role of Gabapentin in the management of Pentazocine dependence for suppressing muscle aching and craving during its withdrawal.

MATERIAL AND METHODS

Patients of Pentazocine dependence were divided in two groups GpA and GpB (n = 10 in each) and were administered Clonidine (P.O.) in first seven days (acute detoxification phase) and later Naltrexone (P.O.) from seventh day onwards (stabilisation-maintenance phase). Gabapentin (1200 mg/day) was additionally added in group B. Muscle pain and craving were rated on 100 mm visual-analogue scale. Psychological dependence was assessed on four step categorical scale.

RESULTS

Group B (Gabapentin group) scored significantly lower (p < 0.001) than group A on both the parameters. Psychological dependence was significantly low (p < 0.01) in Gabapentin group.

CONCLUSION

Gabapentin is an important adjuvant to the management of opiate dependence both in acute detoxification as well as stabilisation phase.

Authors+Show Affiliations

Department of Medicine, SS Medical College, Rewa (MP).No affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

14621035

Citation

Kumar, P, and M K. Jain. "Gabapentin in the Management of Pentazocine Dependence: a Potent Analgesic--anticraving Agent." The Journal of the Association of Physicians of India, vol. 51, 2003, pp. 673-6.
Kumar P, Jain MK. Gabapentin in the management of pentazocine dependence: a potent analgesic--anticraving agent. J Assoc Physicians India. 2003;51:673-6.
Kumar, P., & Jain, M. K. (2003). Gabapentin in the management of pentazocine dependence: a potent analgesic--anticraving agent. The Journal of the Association of Physicians of India, 51, 673-6.
Kumar P, Jain MK. Gabapentin in the Management of Pentazocine Dependence: a Potent Analgesic--anticraving Agent. J Assoc Physicians India. 2003;51:673-6. PubMed PMID: 14621035.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gabapentin in the management of pentazocine dependence: a potent analgesic--anticraving agent. AU - Kumar,P, AU - Jain,M K, PY - 2003/11/19/pubmed PY - 2004/6/15/medline PY - 2003/11/19/entrez SP - 673 EP - 6 JF - The Journal of the Association of Physicians of India JO - J Assoc Physicians India VL - 51 N2 - OBJECTIVES: To evaluate the role of Gabapentin in the management of Pentazocine dependence for suppressing muscle aching and craving during its withdrawal. MATERIAL AND METHODS: Patients of Pentazocine dependence were divided in two groups GpA and GpB (n = 10 in each) and were administered Clonidine (P.O.) in first seven days (acute detoxification phase) and later Naltrexone (P.O.) from seventh day onwards (stabilisation-maintenance phase). Gabapentin (1200 mg/day) was additionally added in group B. Muscle pain and craving were rated on 100 mm visual-analogue scale. Psychological dependence was assessed on four step categorical scale. RESULTS: Group B (Gabapentin group) scored significantly lower (p < 0.001) than group A on both the parameters. Psychological dependence was significantly low (p < 0.01) in Gabapentin group. CONCLUSION: Gabapentin is an important adjuvant to the management of opiate dependence both in acute detoxification as well as stabilisation phase. SN - 0004-5772 UR - https://www.unboundmedicine.com/medline/citation/14621035/Gabapentin_in_the_management_of_pentazocine_dependence:_a_potent_analgesic__anticraving_agent_ L2 - https://www.lens.org/lens/search?q=citation_id:14621035 DB - PRIME DP - Unbound Medicine ER -