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Controlled release formulation of tramadol hydrochloride using hydrophilic and hydrophobic matrix system.
AAPS PharmSciTech. 2003; 4(3):E31.AP

Abstract

The effect of concentration of hydrophilic (hydroxypropyl methylcellulose [HPMC]) and hydrophobic polymers (hydrogenated castor oil [HCO], ethylcellulose) on the release rate of tramadol was studied. Hydrophilic matrix tablets were prepared by wet granulation technique, while hydrophobic (wax) matrix tablets were prepared by melt granulation technique and in vitro dissolution studies were performed using United States Pharmacopeia (USP) apparatus type II. Hydrophobic matrix tablets resulted in sustained in vitro drug release (>20 hours) as compared with hydrophilic matrix tablets (<14 hours). The presence of ethylcellulose in either of the matrix systems prolonged the release rate of the drug. Tablets prepared by combination of hydrophilic and hydrophobic polymers failed to prolong the drug release beyond 12 hours. The effect of ethylcellulose coating (Surelease) and the presence of lactose and HPMC in the coating composition on the drug release was also investigated. Hydrophobic matrix tablets prepared using HCO were found to be best suited for modulating the delivery of the highly water-soluble drug, tramadol hydrochloride.

Authors+Show Affiliations

Department of Novel Drug Delivery Systems, Zydus Research Centre, Sarkhej Bavala National Highway No 8A, Moraiya, Ahmedabad- 382 213, Gujarat, India. sandiptiwari@zyduscadila.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14621963

Citation

Tiwari, Sandip B., et al. "Controlled Release Formulation of Tramadol Hydrochloride Using Hydrophilic and Hydrophobic Matrix System." AAPS PharmSciTech, vol. 4, no. 3, 2003, pp. E31.
Tiwari SB, Murthy TK, Pai MR, et al. Controlled release formulation of tramadol hydrochloride using hydrophilic and hydrophobic matrix system. AAPS PharmSciTech. 2003;4(3):E31.
Tiwari, S. B., Murthy, T. K., Pai, M. R., Mehta, P. R., & Chowdary, P. B. (2003). Controlled release formulation of tramadol hydrochloride using hydrophilic and hydrophobic matrix system. AAPS PharmSciTech, 4(3), E31.
Tiwari SB, et al. Controlled Release Formulation of Tramadol Hydrochloride Using Hydrophilic and Hydrophobic Matrix System. AAPS PharmSciTech. 2003;4(3):E31. PubMed PMID: 14621963.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Controlled release formulation of tramadol hydrochloride using hydrophilic and hydrophobic matrix system. AU - Tiwari,Sandip B, AU - Murthy,T Krishna, AU - Pai,M Raveendra, AU - Mehta,Pavak R, AU - Chowdary,Pasula B, PY - 2003/11/19/pubmed PY - 2004/2/12/medline PY - 2003/11/19/entrez SP - E31 EP - E31 JF - AAPS PharmSciTech JO - AAPS PharmSciTech VL - 4 IS - 3 N2 - The effect of concentration of hydrophilic (hydroxypropyl methylcellulose [HPMC]) and hydrophobic polymers (hydrogenated castor oil [HCO], ethylcellulose) on the release rate of tramadol was studied. Hydrophilic matrix tablets were prepared by wet granulation technique, while hydrophobic (wax) matrix tablets were prepared by melt granulation technique and in vitro dissolution studies were performed using United States Pharmacopeia (USP) apparatus type II. Hydrophobic matrix tablets resulted in sustained in vitro drug release (>20 hours) as compared with hydrophilic matrix tablets (<14 hours). The presence of ethylcellulose in either of the matrix systems prolonged the release rate of the drug. Tablets prepared by combination of hydrophilic and hydrophobic polymers failed to prolong the drug release beyond 12 hours. The effect of ethylcellulose coating (Surelease) and the presence of lactose and HPMC in the coating composition on the drug release was also investigated. Hydrophobic matrix tablets prepared using HCO were found to be best suited for modulating the delivery of the highly water-soluble drug, tramadol hydrochloride. SN - 1530-9932 UR - https://www.unboundmedicine.com/medline/citation/14621963/Controlled_release_formulation_of_tramadol_hydrochloride_using_hydrophilic_and_hydrophobic_matrix_system_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/14621963/ DB - PRIME DP - Unbound Medicine ER -