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[Revisiting the clomifene-gonadotropin protocol in IVF with the use of a GnRH antagonist].
Gynecol Obstet Fertil. 2003 Nov; 31(11):927-31.GO

Abstract

OBJECTIVE

To assess the ability of GnRH antagonists to prevent LH surges during superovulation for IVF in classical stimulation protocols with clomiphene and gonadotropins.

PATIENTS AND METHODS

Fifty-eight patients were treated with clomiphene (100 mg daily for 5 days starting on cycle day 2) and gonadotropins (225 UI HMG on cycle days 5, 7 and 9), with monitoring starting on cycle day 10. Cetrorelix, 0.25 mg, was administered daily when dominant follicle diameter reached 18 mm and/or plasma estradiol levels 800 pg/ml.

RESULTS

No premature LH surge was observed during the 48 stimulation cycles completed. The pregnancy rate was 20.8% per punction and 25.6% per transfer, and there was no clinical ovarian hyperstimulation syndrome in these series.

CONCLUSIONS

Cetrorelix, 0.25 mg, optimizes the classical stimulation with clomiphene and gonadotropins by preventing LH surges; the so-completed protocol yields acceptable pregnancy rates with lower hormone quantities and reduced risks of ovarian hyperstimulation, and becomes a convenient choice when "softer" treatments for IVF are considered.

Authors+Show Affiliations

Centre de FIV Aquitaine-Santé, clinique Jean-Villar, 33520 Bruges, France. jc.emperaire@aquitanesante.frNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

14623556

Citation

Emperaire, J-C, et al. "[Revisiting the Clomifene-gonadotropin Protocol in IVF With the Use of a GnRH Antagonist]." Gynecologie, Obstetrique & Fertilite, vol. 31, no. 11, 2003, pp. 927-31.
Emperaire JC, Parneix I, Perraguin-Jayot S. [Revisiting the clomifene-gonadotropin protocol in IVF with the use of a GnRH antagonist]. Gynecol Obstet Fertil. 2003;31(11):927-31.
Emperaire, J. C., Parneix, I., & Perraguin-Jayot, S. (2003). [Revisiting the clomifene-gonadotropin protocol in IVF with the use of a GnRH antagonist]. Gynecologie, Obstetrique & Fertilite, 31(11), 927-31.
Emperaire JC, Parneix I, Perraguin-Jayot S. [Revisiting the Clomifene-gonadotropin Protocol in IVF With the Use of a GnRH Antagonist]. Gynecol Obstet Fertil. 2003;31(11):927-31. PubMed PMID: 14623556.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Revisiting the clomifene-gonadotropin protocol in IVF with the use of a GnRH antagonist]. AU - Emperaire,J-C, AU - Parneix,I, AU - Perraguin-Jayot,S, PY - 2003/11/19/pubmed PY - 2004/2/11/medline PY - 2003/11/19/entrez SP - 927 EP - 31 JF - Gynecologie, obstetrique & fertilite JO - Gynecol Obstet Fertil VL - 31 IS - 11 N2 - OBJECTIVE: To assess the ability of GnRH antagonists to prevent LH surges during superovulation for IVF in classical stimulation protocols with clomiphene and gonadotropins. PATIENTS AND METHODS: Fifty-eight patients were treated with clomiphene (100 mg daily for 5 days starting on cycle day 2) and gonadotropins (225 UI HMG on cycle days 5, 7 and 9), with monitoring starting on cycle day 10. Cetrorelix, 0.25 mg, was administered daily when dominant follicle diameter reached 18 mm and/or plasma estradiol levels 800 pg/ml. RESULTS: No premature LH surge was observed during the 48 stimulation cycles completed. The pregnancy rate was 20.8% per punction and 25.6% per transfer, and there was no clinical ovarian hyperstimulation syndrome in these series. CONCLUSIONS: Cetrorelix, 0.25 mg, optimizes the classical stimulation with clomiphene and gonadotropins by preventing LH surges; the so-completed protocol yields acceptable pregnancy rates with lower hormone quantities and reduced risks of ovarian hyperstimulation, and becomes a convenient choice when "softer" treatments for IVF are considered. SN - 1297-9589 UR - https://www.unboundmedicine.com/medline/citation/14623556/[Revisiting_the_clomifene_gonadotropin_protocol_in_IVF_with_the_use_of_a_GnRH_antagonist]_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1297958903002571 DB - PRIME DP - Unbound Medicine ER -