Tags

Type your tag names separated by a space and hit enter

The objective severity assessment of atopic dermatitis score: an objective measure using permeability barrier function and stratum corneum hydration with computer-assisted estimates for extent of disease.
Arch Dermatol 2003; 139(11):1417-22AD

Abstract

OBJECTIVES

Clinical scores used to assess the severity of atopic dermatitis (AD) rely entirely on subjective criteria to evaluate the severity of lesions and the extent of involvement. The aim of this study was to develop an objective measure of AD severity by measuring stratum corneum (SC) functions and by using computer-assisted estimates of involved body surface areas (BSAs).

DESIGN

Barrier function of the SC was assessed by measuring transepidermal water loss, and SC hydration was assessed by measuring capacitance. The extent of disease was assessed using a computer-assisted algorithm.

PATIENTS

A total of 38 sequential volunteers aged 4 months to 18 years (25 girls, 13 boys) with mild to severe AD at a university outpatient pediatric dermatology clinic.

MAIN OUTCOME MEASURES

The computer-assisted method for estimating BSA was compared with estimates using the "rule of nines." The Objective Severity Assessment of Atopic Dermatitis (OSAAD) score, derived from measurements of SC barrier function and SC hydration and normalized for extent of disease was compared with the Scoring Atopic Dermatitis (SCORAD) index.

RESULTS

Measurements of epidermal permeability barrier function and SC hydration correlated with clinical estimates of disease severity. The computer-assisted measurements of the extent of disease correlated with estimates derived from the rule of nines. The OSAAD scores correlated with the currently used instrument for AD severity, the SCORAD index.

CONCLUSION

The OSAAD is a new AD severity score that avoids the pitfalls of currently used subjective scoring systems by using objective measures.

Authors+Show Affiliations

Departments of Dermatology, University of California, San Francisco 94115, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Validation Studies

Language

eng

PubMed ID

14623701

Citation

Sugarman, Jeffrey L., et al. "The Objective Severity Assessment of Atopic Dermatitis Score: an Objective Measure Using Permeability Barrier Function and Stratum Corneum Hydration With Computer-assisted Estimates for Extent of Disease." Archives of Dermatology, vol. 139, no. 11, 2003, pp. 1417-22.
Sugarman JL, Fluhr JW, Fowler AJ, et al. The objective severity assessment of atopic dermatitis score: an objective measure using permeability barrier function and stratum corneum hydration with computer-assisted estimates for extent of disease. Arch Dermatol. 2003;139(11):1417-22.
Sugarman, J. L., Fluhr, J. W., Fowler, A. J., Bruckner, T., Diepgen, T. L., & Williams, M. L. (2003). The objective severity assessment of atopic dermatitis score: an objective measure using permeability barrier function and stratum corneum hydration with computer-assisted estimates for extent of disease. Archives of Dermatology, 139(11), pp. 1417-22.
Sugarman JL, et al. The Objective Severity Assessment of Atopic Dermatitis Score: an Objective Measure Using Permeability Barrier Function and Stratum Corneum Hydration With Computer-assisted Estimates for Extent of Disease. Arch Dermatol. 2003;139(11):1417-22. PubMed PMID: 14623701.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The objective severity assessment of atopic dermatitis score: an objective measure using permeability barrier function and stratum corneum hydration with computer-assisted estimates for extent of disease. AU - Sugarman,Jeffrey L, AU - Fluhr,Joachim W, AU - Fowler,Ashley J, AU - Bruckner,Thomas, AU - Diepgen,Thomas L, AU - Williams,Mary L, PY - 2003/11/19/pubmed PY - 2003/12/5/medline PY - 2003/11/19/entrez SP - 1417 EP - 22 JF - Archives of dermatology JO - Arch Dermatol VL - 139 IS - 11 N2 - OBJECTIVES: Clinical scores used to assess the severity of atopic dermatitis (AD) rely entirely on subjective criteria to evaluate the severity of lesions and the extent of involvement. The aim of this study was to develop an objective measure of AD severity by measuring stratum corneum (SC) functions and by using computer-assisted estimates of involved body surface areas (BSAs). DESIGN: Barrier function of the SC was assessed by measuring transepidermal water loss, and SC hydration was assessed by measuring capacitance. The extent of disease was assessed using a computer-assisted algorithm. PATIENTS: A total of 38 sequential volunteers aged 4 months to 18 years (25 girls, 13 boys) with mild to severe AD at a university outpatient pediatric dermatology clinic. MAIN OUTCOME MEASURES: The computer-assisted method for estimating BSA was compared with estimates using the "rule of nines." The Objective Severity Assessment of Atopic Dermatitis (OSAAD) score, derived from measurements of SC barrier function and SC hydration and normalized for extent of disease was compared with the Scoring Atopic Dermatitis (SCORAD) index. RESULTS: Measurements of epidermal permeability barrier function and SC hydration correlated with clinical estimates of disease severity. The computer-assisted measurements of the extent of disease correlated with estimates derived from the rule of nines. The OSAAD scores correlated with the currently used instrument for AD severity, the SCORAD index. CONCLUSION: The OSAAD is a new AD severity score that avoids the pitfalls of currently used subjective scoring systems by using objective measures. SN - 0003-987X UR - https://www.unboundmedicine.com/medline/citation/14623701/The_objective_severity_assessment_of_atopic_dermatitis_score:_an_objective_measure_using_permeability_barrier_function_and_stratum_corneum_hydration_with_computer_assisted_estimates_for_extent_of_disease_ L2 - https://jamanetwork.com/journals/jamadermatology/fullarticle/vol/139/pg/1417 DB - PRIME DP - Unbound Medicine ER -