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Omega-3 fatty acids and risk of cognitive impairment and dementia.
J Alzheimers Dis. 2003 Aug; 5(4):315-22.JA

Abstract

It has been suggested that the dietary intake of omega-3 polyunsaturated fatty acids could be inversely related to the risk of dementia and cognitive decline. This analysis examined the association between plasma concentration of omega-3 polyunsaturated fatty acids and prevalence and incidence of cognitive impairment and dementia. Data are reported on subjects 65 years or older who had a complete clinical evaluation at the first two waves (1991-1992 and 1996-1997) of the Canadian Study of Health and Aging. Main outcome measures were cognitive impairment and dementia by mean relative plasma concentrations of fatty acids in the phospholipid fraction at baseline. Results were adjusted for age, sex, education, smoking, alcohol intake, body mass index, history of cardiovascular disease, and apolipoprotein E e4 genotype. In the cross-sectional analysis, no significant difference in omega-3 polyunsaturated fatty acid concentrations was observed between controls and both prevalent cases of cognitive impairment and dementia. In the prospective analysis, a higher eicosapentaenoic acid (p < 0.01) concentration was found in cognitively impaired cases compared to controls while higher docosahexaenoic acid (p < 0.07), omega-3 (p < 0.04) and total polyunsaturated fatty acid (p < 0.03) concentrations were found in dementia cases. These findings do not support the hypothesis that omega-3 polyunsaturated fatty acids play a protective role in cognitive function and dementia.

Authors+Show Affiliations

Laval University Geriatric Research Unit, Quebec, QC, Canada. Danielle.Laurin@cha.quebec.qc.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14624027

Citation

Laurin, Danielle, et al. "Omega-3 Fatty Acids and Risk of Cognitive Impairment and Dementia." Journal of Alzheimer's Disease : JAD, vol. 5, no. 4, 2003, pp. 315-22.
Laurin D, Verreault R, Lindsay J, et al. Omega-3 fatty acids and risk of cognitive impairment and dementia. J Alzheimers Dis. 2003;5(4):315-22.
Laurin, D., Verreault, R., Lindsay, J., Dewailly, E., & Holub, B. J. (2003). Omega-3 fatty acids and risk of cognitive impairment and dementia. Journal of Alzheimer's Disease : JAD, 5(4), 315-22.
Laurin D, et al. Omega-3 Fatty Acids and Risk of Cognitive Impairment and Dementia. J Alzheimers Dis. 2003;5(4):315-22. PubMed PMID: 14624027.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Omega-3 fatty acids and risk of cognitive impairment and dementia. AU - Laurin,Danielle, AU - Verreault,René, AU - Lindsay,Joan, AU - Dewailly,Eric, AU - Holub,Bruce J, PY - 2003/11/19/pubmed PY - 2004/3/20/medline PY - 2003/11/19/entrez SP - 315 EP - 22 JF - Journal of Alzheimer's disease : JAD JO - J Alzheimers Dis VL - 5 IS - 4 N2 - It has been suggested that the dietary intake of omega-3 polyunsaturated fatty acids could be inversely related to the risk of dementia and cognitive decline. This analysis examined the association between plasma concentration of omega-3 polyunsaturated fatty acids and prevalence and incidence of cognitive impairment and dementia. Data are reported on subjects 65 years or older who had a complete clinical evaluation at the first two waves (1991-1992 and 1996-1997) of the Canadian Study of Health and Aging. Main outcome measures were cognitive impairment and dementia by mean relative plasma concentrations of fatty acids in the phospholipid fraction at baseline. Results were adjusted for age, sex, education, smoking, alcohol intake, body mass index, history of cardiovascular disease, and apolipoprotein E e4 genotype. In the cross-sectional analysis, no significant difference in omega-3 polyunsaturated fatty acid concentrations was observed between controls and both prevalent cases of cognitive impairment and dementia. In the prospective analysis, a higher eicosapentaenoic acid (p < 0.01) concentration was found in cognitively impaired cases compared to controls while higher docosahexaenoic acid (p < 0.07), omega-3 (p < 0.04) and total polyunsaturated fatty acid (p < 0.03) concentrations were found in dementia cases. These findings do not support the hypothesis that omega-3 polyunsaturated fatty acids play a protective role in cognitive function and dementia. SN - 1387-2877 UR - https://www.unboundmedicine.com/medline/citation/14624027/Omega_3_fatty_acids_and_risk_of_cognitive_impairment_and_dementia_ DB - PRIME DP - Unbound Medicine ER -