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The effect of combining plant sterols, soy protein, viscous fibers, and almonds in treating hypercholesterolemia.

Abstract

Reductions in low-density lipoprotein-cholesterol (LDL-C) result from diets containing almonds, or diets that are either low in saturated fat or high in viscous fibers, soy proteins, or plant sterols. We have therefore combined all of these interventions in a single diet (portfolio diet) to determine whether cholesterol reductions could be achieved of similar magnitude to those reported in recent statin trials which reduced cardiovascular events. Twenty-five hyperlipidemic subjects consumed either a portfolio diet (n=13), very low in saturated fat and high in plant sterols (1.2 g/1,000 kcal), soy protein (16.2 g/1,000 kcal), viscous fibers (8.3 g/1,000 kcal), and almonds (16.6 g/1,000 kcal), or a low-saturated fat diet (n=12) based on whole-wheat cereals and low-fat dairy foods. Fasting blood, blood pressure, and body weight were obtained at weeks 0, 2, and 4 of each phase. LDL-C was reduced by 12.1% +/- 2.4% (P<.001) on the low-fat diet and by 35.0% +/- 3.1% (P<.001) on the portfolio diet, which also reduced the ratio of LDL-C to high-density lipoprotein-cholesterol (HDL-C) significantly (30.0% +/- 3.5%; P<.001). The reductions in LDL-C and the LDL:HDL-C ratio were both significantly lower on the portfolio diet than on the control diet (P<.001 and P<.001, respectively). Mean weight loss was similar on test and control diets (1.0 kg and 0.9 kg, respectively). No difference was seen in blood pressure, HDL-C, serum triglycerides, lipoprotein(a) [Lp(a)], or homocysteine concentrations between diets. Combining a number of foods and food components in a single dietary portfolio may lower LDL-C similarly to statins and so increase the potential effectiveness of dietary therapy.

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  • Authors+Show Affiliations

    ,

    Clinical Nutrition and Risk Factor Modification Center, St. Michael's Hospital, Toronto, Ontario, Canada.

    , , , , , , , , ,

    Source

    Metabolism: clinical and experimental 52:11 2003 Nov pg 1478-83

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Cholesterol
    Cholesterol, Dietary
    Dietary Carbohydrates
    Dietary Fats
    Dietary Fiber
    Erythrocyte Deformability
    Female
    Food Preferences
    Homocysteine
    Humans
    Hypercholesterolemia
    Hyperlipidemias
    Male
    Middle Aged
    Phytosterols
    Prunus
    Risk Factors
    Satiety Response
    Soybean Proteins

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    14624410

    Citation

    Jenkins, David J A., et al. "The Effect of Combining Plant Sterols, Soy Protein, Viscous Fibers, and Almonds in Treating Hypercholesterolemia." Metabolism: Clinical and Experimental, vol. 52, no. 11, 2003, pp. 1478-83.
    Jenkins DJ, Kendall CW, Marchie A, et al. The effect of combining plant sterols, soy protein, viscous fibers, and almonds in treating hypercholesterolemia. Metab Clin Exp. 2003;52(11):1478-83.
    Jenkins, D. J., Kendall, C. W., Marchie, A., Faulkner, D., Vidgen, E., Lapsley, K. G., ... Connelly, P. W. (2003). The effect of combining plant sterols, soy protein, viscous fibers, and almonds in treating hypercholesterolemia. Metabolism: Clinical and Experimental, 52(11), pp. 1478-83.
    Jenkins DJ, et al. The Effect of Combining Plant Sterols, Soy Protein, Viscous Fibers, and Almonds in Treating Hypercholesterolemia. Metab Clin Exp. 2003;52(11):1478-83. PubMed PMID: 14624410.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The effect of combining plant sterols, soy protein, viscous fibers, and almonds in treating hypercholesterolemia. AU - Jenkins,David J A, AU - Kendall,Cyril W C, AU - Marchie,Augustine, AU - Faulkner,Dorothea, AU - Vidgen,Edward, AU - Lapsley,Karen G, AU - Trautwein,Elke A, AU - Parker,Tina L, AU - Josse,Robert G, AU - Leiter,Lawrence A, AU - Connelly,Philip W, PY - 2003/11/19/pubmed PY - 2003/12/13/medline PY - 2003/11/19/entrez SP - 1478 EP - 83 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 52 IS - 11 N2 - Reductions in low-density lipoprotein-cholesterol (LDL-C) result from diets containing almonds, or diets that are either low in saturated fat or high in viscous fibers, soy proteins, or plant sterols. We have therefore combined all of these interventions in a single diet (portfolio diet) to determine whether cholesterol reductions could be achieved of similar magnitude to those reported in recent statin trials which reduced cardiovascular events. Twenty-five hyperlipidemic subjects consumed either a portfolio diet (n=13), very low in saturated fat and high in plant sterols (1.2 g/1,000 kcal), soy protein (16.2 g/1,000 kcal), viscous fibers (8.3 g/1,000 kcal), and almonds (16.6 g/1,000 kcal), or a low-saturated fat diet (n=12) based on whole-wheat cereals and low-fat dairy foods. Fasting blood, blood pressure, and body weight were obtained at weeks 0, 2, and 4 of each phase. LDL-C was reduced by 12.1% +/- 2.4% (P<.001) on the low-fat diet and by 35.0% +/- 3.1% (P<.001) on the portfolio diet, which also reduced the ratio of LDL-C to high-density lipoprotein-cholesterol (HDL-C) significantly (30.0% +/- 3.5%; P<.001). The reductions in LDL-C and the LDL:HDL-C ratio were both significantly lower on the portfolio diet than on the control diet (P<.001 and P<.001, respectively). Mean weight loss was similar on test and control diets (1.0 kg and 0.9 kg, respectively). No difference was seen in blood pressure, HDL-C, serum triglycerides, lipoprotein(a) [Lp(a)], or homocysteine concentrations between diets. Combining a number of foods and food components in a single dietary portfolio may lower LDL-C similarly to statins and so increase the potential effectiveness of dietary therapy. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/14624410/The_effect_of_combining_plant_sterols_soy_protein_viscous_fibers_and_almonds_in_treating_hypercholesterolemia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026049503002609 DB - PRIME DP - Unbound Medicine ER -