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Modulation of the liver export protein synthetic response to feeding by an n-3 fatty-acid-enriched nutritional supplement is associated with anabolism in cachectic cancer patients.
Clin Sci (Lond). 2004 Apr; 106(4):359-64.CS

Abstract

The acute-phase protein response is associated with accelerated weight loss and shortened survival in cancer. This may be due to hepatic protein synthesis increasing demand for amino acids. An n -3 fatty-acid-enriched nutritional supplement will moderate aspects of cachexia in cancer patients. The present study examined the effect of such a supplement on hepatic synthesis of albumin and fibrinogen. Albumin and fibrinogen synthesis were measured in the fed and fasting state in eight weight-losing patients with pancreatic cancer by an intravenous flooding dose technique. Tracer incorporation into proteins was measured by GC/MS. Patients were restudied after 3 weeks of oral supplement enriched with fish oil (providing 2510 kJ/day and 2 g of eicosapentaenoic acid/day). At baseline, all patients were losing weight (median, 2.4 kg/month). After 3 weeks of consumption of the fish-oil-enriched nutritional supplement, patients' weight stabilized (median change, +1 kg; P = 0.01). At baseline, albumin and fibrinogen synthesis rates were stimulated in the fed compared with the fasting state [14.2 compared with 11.3 g/day (29% rise; P = 0.01) and 4.5 compared with 3.3 g/day (38% rise; P = 0.01) respectively]. After 3 weeks of the supplement, this stimulation in the fed state was no longer observed for albumin and was reduced for fibrinogen [11.2 compared with 10.5 g/day (3% rise; P = 0.21) and 3.7 compared with 2.9 g/day (17% rise; P = 0.01) respectively]. After 3 weeks, the combined albumin plus fibrinogen synthetic rate tended to fall in the fasting state (14.7 compared with 12.3 g/day; P = 0.09) and was significantly reduced in the fed state (18.7 compared with 14.6 g/day; P = 0.01). Modulation of hepatic export protein synthesis with feeding may have contributed to the net whole-body anabolism observed with administration of the n -3 fatty-acid-enriched oral supplement.

Authors+Show Affiliations

Department of Clinical and Surgical Sciences (Surgery), The University of Edinburgh, Royal Infirmary, Edinburgh EH16 4SA, Scotland, U.K.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14624668

Citation

Barber, Matthew D., et al. "Modulation of the Liver Export Protein Synthetic Response to Feeding By an N-3 Fatty-acid-enriched Nutritional Supplement Is Associated With Anabolism in Cachectic Cancer Patients." Clinical Science (London, England : 1979), vol. 106, no. 4, 2004, pp. 359-64.
Barber MD, Preston T, McMillan DC, et al. Modulation of the liver export protein synthetic response to feeding by an n-3 fatty-acid-enriched nutritional supplement is associated with anabolism in cachectic cancer patients. Clin Sci (Lond). 2004;106(4):359-64.
Barber, M. D., Preston, T., McMillan, D. C., Slater, C., Ross, J. A., & Fearon, K. C. (2004). Modulation of the liver export protein synthetic response to feeding by an n-3 fatty-acid-enriched nutritional supplement is associated with anabolism in cachectic cancer patients. Clinical Science (London, England : 1979), 106(4), 359-64.
Barber MD, et al. Modulation of the Liver Export Protein Synthetic Response to Feeding By an N-3 Fatty-acid-enriched Nutritional Supplement Is Associated With Anabolism in Cachectic Cancer Patients. Clin Sci (Lond). 2004;106(4):359-64. PubMed PMID: 14624668.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulation of the liver export protein synthetic response to feeding by an n-3 fatty-acid-enriched nutritional supplement is associated with anabolism in cachectic cancer patients. AU - Barber,Matthew D, AU - Preston,Tom, AU - McMillan,Donald C, AU - Slater,Christine, AU - Ross,James A, AU - Fearon,Kenneth C H, PY - 2003/11/18/accepted PY - 2003/11/10/revised PY - 2003/09/12/received PY - 2003/11/20/pubmed PY - 2004/6/5/medline PY - 2003/11/20/entrez SP - 359 EP - 64 JF - Clinical science (London, England : 1979) JO - Clin Sci (Lond) VL - 106 IS - 4 N2 - The acute-phase protein response is associated with accelerated weight loss and shortened survival in cancer. This may be due to hepatic protein synthesis increasing demand for amino acids. An n -3 fatty-acid-enriched nutritional supplement will moderate aspects of cachexia in cancer patients. The present study examined the effect of such a supplement on hepatic synthesis of albumin and fibrinogen. Albumin and fibrinogen synthesis were measured in the fed and fasting state in eight weight-losing patients with pancreatic cancer by an intravenous flooding dose technique. Tracer incorporation into proteins was measured by GC/MS. Patients were restudied after 3 weeks of oral supplement enriched with fish oil (providing 2510 kJ/day and 2 g of eicosapentaenoic acid/day). At baseline, all patients were losing weight (median, 2.4 kg/month). After 3 weeks of consumption of the fish-oil-enriched nutritional supplement, patients' weight stabilized (median change, +1 kg; P = 0.01). At baseline, albumin and fibrinogen synthesis rates were stimulated in the fed compared with the fasting state [14.2 compared with 11.3 g/day (29% rise; P = 0.01) and 4.5 compared with 3.3 g/day (38% rise; P = 0.01) respectively]. After 3 weeks of the supplement, this stimulation in the fed state was no longer observed for albumin and was reduced for fibrinogen [11.2 compared with 10.5 g/day (3% rise; P = 0.21) and 3.7 compared with 2.9 g/day (17% rise; P = 0.01) respectively]. After 3 weeks, the combined albumin plus fibrinogen synthetic rate tended to fall in the fasting state (14.7 compared with 12.3 g/day; P = 0.09) and was significantly reduced in the fed state (18.7 compared with 14.6 g/day; P = 0.01). Modulation of hepatic export protein synthesis with feeding may have contributed to the net whole-body anabolism observed with administration of the n -3 fatty-acid-enriched oral supplement. SN - 0143-5221 UR - https://www.unboundmedicine.com/medline/citation/14624668/Modulation_of_the_liver_export_protein_synthetic_response_to_feeding_by_an_n_3_fatty_acid_enriched_nutritional_supplement_is_associated_with_anabolism_in_cachectic_cancer_patients_ L2 - https://portlandpress.com/clinsci/article-lookup/doi/10.1042/CS20030301 DB - PRIME DP - Unbound Medicine ER -