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Nitric oxide synthase expressions in rat dorsal root ganglion after a hind limb tourniquet.
Neuroreport. 2003 Dec 02; 14(17):2267-70.N

Abstract

We investigated the mRNA levels of neuronal, inducible, endothelial nitric oxide synthases (nNOS, iNOS, eNOS) and tumor necrosis factor-alpha (TNF-alpha) in a rat dorsal root ganglion (DRG) after tourniquet application to a hind limb to identify molecules that trigger secondary events after peripheral nerve injury. Significantly high nNOS, iNOS mRNA and protein levels were observed in the ipsilateral DRGs 4 h after tourniquet application but not in the contralateral or control DRGs. The levels of TNF-alpha, an inducer of iNOS, were significantly increased in the ipsilateral DRGs 1 h after tourniquet application. Large amounts of NO might result in damage to the host cells and induce apotosis to eliminate damaged cells during the early stage of nerve injury.

Authors+Show Affiliations

Department of Legal Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan. sumiko@fmu.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14625460

Citation

Abe, Sumiko, et al. "Nitric Oxide Synthase Expressions in Rat Dorsal Root Ganglion After a Hind Limb Tourniquet." Neuroreport, vol. 14, no. 17, 2003, pp. 2267-70.
Abe S, Mizusawa I, Kanno K, et al. Nitric oxide synthase expressions in rat dorsal root ganglion after a hind limb tourniquet. Neuroreport. 2003;14(17):2267-70.
Abe, S., Mizusawa, I., Kanno, K., Yabashi, A., Suto, M., Kuraya, M., Honda, T., & Hiraiwa, K. (2003). Nitric oxide synthase expressions in rat dorsal root ganglion after a hind limb tourniquet. Neuroreport, 14(17), 2267-70.
Abe S, et al. Nitric Oxide Synthase Expressions in Rat Dorsal Root Ganglion After a Hind Limb Tourniquet. Neuroreport. 2003 Dec 2;14(17):2267-70. PubMed PMID: 14625460.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nitric oxide synthase expressions in rat dorsal root ganglion after a hind limb tourniquet. AU - Abe,Sumiko, AU - Mizusawa,Ikubumi, AU - Kanno,Katsuyuki, AU - Yabashi,Atsuko, AU - Suto,Miwako, AU - Kuraya,Mikio, AU - Honda,Takashi, AU - Hiraiwa,Kouichi, PY - 2003/11/20/pubmed PY - 2004/5/27/medline PY - 2003/11/20/entrez SP - 2267 EP - 70 JF - Neuroreport JO - Neuroreport VL - 14 IS - 17 N2 - We investigated the mRNA levels of neuronal, inducible, endothelial nitric oxide synthases (nNOS, iNOS, eNOS) and tumor necrosis factor-alpha (TNF-alpha) in a rat dorsal root ganglion (DRG) after tourniquet application to a hind limb to identify molecules that trigger secondary events after peripheral nerve injury. Significantly high nNOS, iNOS mRNA and protein levels were observed in the ipsilateral DRGs 4 h after tourniquet application but not in the contralateral or control DRGs. The levels of TNF-alpha, an inducer of iNOS, were significantly increased in the ipsilateral DRGs 1 h after tourniquet application. Large amounts of NO might result in damage to the host cells and induce apotosis to eliminate damaged cells during the early stage of nerve injury. SN - 0959-4965 UR - https://www.unboundmedicine.com/medline/citation/14625460/Nitric_oxide_synthase_expressions_in_rat_dorsal_root_ganglion_after_a_hind_limb_tourniquet_ L2 - https://doi.org/10.1097/00001756-200312020-00026 DB - PRIME DP - Unbound Medicine ER -