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Effects of scutellarin on liver function after brain ischemia/reperfusion in rats.
Acta Pharmacol Sin. 2003 Nov; 24(11):1118-24.AP

Abstract

AIM

To investigate the effects of scutellarin (Scu) on liver function after brain ischemia/reperfusion in Wistar rats.

METHODS

Rats were pretreated with Scu for 7 d and then subjected to a brain ischemia/reperfusion injury induced by a middle cerebral artery occlusion. The levels of nitric oxide (NO), xanthine oxidase (XOD), alanine transaminase (ALT), and aspartate aminotransferase (AST) in serum or liver tissues and the activities of antioxidant enzymes and cytochrome P450-dependent monooxygenases (CYPs) in liver tissues after brain ischemia/reperfusion were determined.

RESULTS

In vehicle-treated rats, XOD, ALT, and AST activities (P<0.01) in serum and the MDA level (P<0.05) in liver tissues were all elevated but were significantly reduced (P<0.05) by Scu pretreatment. The NO levels in serum and liver tissues were decreased (P<0.01) dramatically in vehicle-treated rats and returned to the levels in the sham-operated animals when pretreated with Scu. SOD (P<0.05) and GSH-PX (P<0.01) activities in cytosol fraction were increased significantly by Scu pretreatment. Furthermore, a loss of CYP3A activity (P<0.01), but no changes of CYP1A1, CYP1A2, and CYP2E1 activities in liver were observed after brain ischemia/reperfusion in rats. Scu had no effect on them.

CONCLUSION

These results demonstrated that pretreatment with Scu could attenuate hepatocellular damage elicited by brain ischemia/reperfusion in rats and this protection is in major part by its antioxidant activity.

Authors+Show Affiliations

Department of Clinical Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14627496

Citation

Yang, Xiu-Fen, et al. "Effects of Scutellarin On Liver Function After Brain Ischemia/reperfusion in Rats." Acta Pharmacologica Sinica, vol. 24, no. 11, 2003, pp. 1118-24.
Yang XF, He W, Lu WH, et al. Effects of scutellarin on liver function after brain ischemia/reperfusion in rats. Acta Pharmacol Sin. 2003;24(11):1118-24.
Yang, X. F., He, W., Lu, W. H., & Zeng, F. D. (2003). Effects of scutellarin on liver function after brain ischemia/reperfusion in rats. Acta Pharmacologica Sinica, 24(11), 1118-24.
Yang XF, et al. Effects of Scutellarin On Liver Function After Brain Ischemia/reperfusion in Rats. Acta Pharmacol Sin. 2003;24(11):1118-24. PubMed PMID: 14627496.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of scutellarin on liver function after brain ischemia/reperfusion in rats. AU - Yang,Xiu-Fen, AU - He,Wei, AU - Lu,Wen-Hong, AU - Zeng,Fan-Dian, PY - 2003/11/25/pubmed PY - 2004/8/7/medline PY - 2003/11/25/entrez SP - 1118 EP - 24 JF - Acta pharmacologica Sinica JO - Acta Pharmacol Sin VL - 24 IS - 11 N2 - AIM: To investigate the effects of scutellarin (Scu) on liver function after brain ischemia/reperfusion in Wistar rats. METHODS: Rats were pretreated with Scu for 7 d and then subjected to a brain ischemia/reperfusion injury induced by a middle cerebral artery occlusion. The levels of nitric oxide (NO), xanthine oxidase (XOD), alanine transaminase (ALT), and aspartate aminotransferase (AST) in serum or liver tissues and the activities of antioxidant enzymes and cytochrome P450-dependent monooxygenases (CYPs) in liver tissues after brain ischemia/reperfusion were determined. RESULTS: In vehicle-treated rats, XOD, ALT, and AST activities (P<0.01) in serum and the MDA level (P<0.05) in liver tissues were all elevated but were significantly reduced (P<0.05) by Scu pretreatment. The NO levels in serum and liver tissues were decreased (P<0.01) dramatically in vehicle-treated rats and returned to the levels in the sham-operated animals when pretreated with Scu. SOD (P<0.05) and GSH-PX (P<0.01) activities in cytosol fraction were increased significantly by Scu pretreatment. Furthermore, a loss of CYP3A activity (P<0.01), but no changes of CYP1A1, CYP1A2, and CYP2E1 activities in liver were observed after brain ischemia/reperfusion in rats. Scu had no effect on them. CONCLUSION: These results demonstrated that pretreatment with Scu could attenuate hepatocellular damage elicited by brain ischemia/reperfusion in rats and this protection is in major part by its antioxidant activity. SN - 1671-4083 UR - https://www.unboundmedicine.com/medline/citation/14627496/Effects_of_scutellarin_on_liver_function_after_brain_ischemia/reperfusion_in_rats_ DB - PRIME DP - Unbound Medicine ER -