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Serum oxidized low-density lipoproteins in rheumatoid arthritis.

Abstract

OBJECTIVE

The aim of this study was to measure serum oxidized low-density lipoprotein (Ox-LDL) levels in patients with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE) and to identify any association with clinical variables.

METHODS

We studied 126 female patients (27 with active RA, 27 with inactive RA, 72 with SLE). One hundred fifteen age-matched healthy women (76 for RA, 39 for SLE) with no clinical or laboratory evidence of disease served as normal controls. Serum Ox-LDL levels were measured with a commercial enzyme-linked immunosorbent assay kit (Mercodia, Sweden).

RESULTS

The serum Ox-LDL levels were significantly higher in patients with active RA (P<0.05) or SLE (P<0.01) than age-matched controls and significantly higher in patients with active RA than with inactive RA (P<0.01). The levels of serum total cholesterol and LDL were significantly lower in patients with RA than in age-matched controls (P<0.01). There was no correlation among serum Ox-LDL levels and inflammatory markers (erythrocyte sedimentation rate, C-reactive protein) or rheumatoid factors in patients with RA.

CONCLUSIONS

Compared with healthy women, those with SLE or active RA had increased serum Ox-LDL levels, which may contribute to the increased risk of cardiovascular disease in this patient group.

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  • Authors+Show Affiliations

    ,

    Division of Allergy and Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. junjan@dongguk.ac.kr

    , , , , ,

    Source

    Rheumatology international 24:4 2004 Jul pg 230-3

    MeSH

    Adult
    Aged
    Arthritis, Rheumatoid
    Blood Sedimentation
    C-Reactive Protein
    Enzyme-Linked Immunosorbent Assay
    Female
    Humans
    Lipoproteins, LDL
    Lupus Erythematosus, Systemic
    Middle Aged
    Oxidation-Reduction
    Rheumatoid Factor

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    14628150

    Citation

    Kim, Seong-Ho, et al. "Serum Oxidized Low-density Lipoproteins in Rheumatoid Arthritis." Rheumatology International, vol. 24, no. 4, 2004, pp. 230-3.
    Kim SH, Lee CK, Lee EY, et al. Serum oxidized low-density lipoproteins in rheumatoid arthritis. Rheumatol Int. 2004;24(4):230-3.
    Kim, S. H., Lee, C. K., Lee, E. Y., Park, S. Y., Cho, Y. S., Yoo, B., & Moon, H. B. (2004). Serum oxidized low-density lipoproteins in rheumatoid arthritis. Rheumatology International, 24(4), pp. 230-3.
    Kim SH, et al. Serum Oxidized Low-density Lipoproteins in Rheumatoid Arthritis. Rheumatol Int. 2004;24(4):230-3. PubMed PMID: 14628150.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Serum oxidized low-density lipoproteins in rheumatoid arthritis. AU - Kim,Seong-Ho, AU - Lee,Chang-Keun, AU - Lee,Eun Young, AU - Park,So Yeon, AU - Cho,You Sook, AU - Yoo,Bin, AU - Moon,Hee-Bom, Y1 - 2003/11/20/ PY - 2003/04/07/received PY - 2003/06/16/accepted PY - 2003/11/25/pubmed PY - 2004/12/24/medline PY - 2003/11/25/entrez SP - 230 EP - 3 JF - Rheumatology international JO - Rheumatol. Int. VL - 24 IS - 4 N2 - OBJECTIVE: The aim of this study was to measure serum oxidized low-density lipoprotein (Ox-LDL) levels in patients with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE) and to identify any association with clinical variables. METHODS: We studied 126 female patients (27 with active RA, 27 with inactive RA, 72 with SLE). One hundred fifteen age-matched healthy women (76 for RA, 39 for SLE) with no clinical or laboratory evidence of disease served as normal controls. Serum Ox-LDL levels were measured with a commercial enzyme-linked immunosorbent assay kit (Mercodia, Sweden). RESULTS: The serum Ox-LDL levels were significantly higher in patients with active RA (P<0.05) or SLE (P<0.01) than age-matched controls and significantly higher in patients with active RA than with inactive RA (P<0.01). The levels of serum total cholesterol and LDL were significantly lower in patients with RA than in age-matched controls (P<0.01). There was no correlation among serum Ox-LDL levels and inflammatory markers (erythrocyte sedimentation rate, C-reactive protein) or rheumatoid factors in patients with RA. CONCLUSIONS: Compared with healthy women, those with SLE or active RA had increased serum Ox-LDL levels, which may contribute to the increased risk of cardiovascular disease in this patient group. SN - 0172-8172 UR - https://www.unboundmedicine.com/medline/citation/14628150/full_citation L2 - https://dx.doi.org/10.1007/s00296-003-0358-4 DB - PRIME DP - Unbound Medicine ER -