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Increased occurrence of diabetes in people with ischemic cardiovascular disease and general and abdominal obesity.
Can J Cardiol 2003; 19(12):1387-91CJ

Abstract

BACKGROUND

Diabetes worsens the prognosis of patients with ischemic cardiovascular disease (ICVD). Increased body weight and abdominal obesity have been shown to increase the risk of diabetes in people without ICVD. Such a relationship has not been assessed in patients with ICVD who may have a different occurrence due to their disease and medications.

OBJECTIVE

To examine the risk of developing diabetes among patients with ICVD according to body mass index (BMI), waist-to-hip ratio and waist circumference

METHODS

Anthropometric measurements were done in 4699 men and 1187 women with ICVD (mean age 66 years) and without known diabetes at entry to the Heart Outcomes Prevention Evaluation (HOPE) study. During the median 4.5-year follow-up, a diagnosis of diabetes was reported in 261 (4.4%) participants.

RESULTS

There was a positive and graded association between increased BMI, waist circumference and waist-to-hip ratio, and the risk of developing diabetes (P for trends <0.0001). After adjusting for all baseline characteristic differences including medications, the relative risk of developing diabetes after the first 40th percentile of each anthropometric measure increased by 12% (95% CI 9% to 15%) for every 1 kg/m2 increase in BMI; the relative risk increased by 5% (95% CI 4% to 6%) for every 1 cm increase in waist circumference and by 38% (95% CI 18% to 61%) for every 0.1 unit increase in waist-to-hip ratio.

CONCLUSION

In patients with ICVD, increased BMI, waist-to-hip ratio and particularly waist circumference constitute independent risk factors for development of diabetes.

Authors+Show Affiliations

Laval University Heart and Lung Institute, Ste-Foy, Quebec, Canada. dagenaisgetr@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14631473

Citation

Dagenais, Gilles R., et al. "Increased Occurrence of Diabetes in People With Ischemic Cardiovascular Disease and General and Abdominal Obesity." The Canadian Journal of Cardiology, vol. 19, no. 12, 2003, pp. 1387-91.
Dagenais GR, Auger P, Bogaty P, et al. Increased occurrence of diabetes in people with ischemic cardiovascular disease and general and abdominal obesity. Can J Cardiol. 2003;19(12):1387-91.
Dagenais, G. R., Auger, P., Bogaty, P., Gerstein, H., Lonn, E., Yi, Q., & Yusuf, S. (2003). Increased occurrence of diabetes in people with ischemic cardiovascular disease and general and abdominal obesity. The Canadian Journal of Cardiology, 19(12), pp. 1387-91.
Dagenais GR, et al. Increased Occurrence of Diabetes in People With Ischemic Cardiovascular Disease and General and Abdominal Obesity. Can J Cardiol. 2003;19(12):1387-91. PubMed PMID: 14631473.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased occurrence of diabetes in people with ischemic cardiovascular disease and general and abdominal obesity. AU - Dagenais,Gilles R, AU - Auger,Pierre, AU - Bogaty,Peter, AU - Gerstein,Hertzel, AU - Lonn,Eva, AU - Yi,Qilong, AU - Yusuf,Salim, AU - ,, PY - 2003/11/25/pubmed PY - 2004/1/6/medline PY - 2003/11/25/entrez SP - 1387 EP - 91 JF - The Canadian journal of cardiology JO - Can J Cardiol VL - 19 IS - 12 N2 - BACKGROUND: Diabetes worsens the prognosis of patients with ischemic cardiovascular disease (ICVD). Increased body weight and abdominal obesity have been shown to increase the risk of diabetes in people without ICVD. Such a relationship has not been assessed in patients with ICVD who may have a different occurrence due to their disease and medications. OBJECTIVE: To examine the risk of developing diabetes among patients with ICVD according to body mass index (BMI), waist-to-hip ratio and waist circumference METHODS: Anthropometric measurements were done in 4699 men and 1187 women with ICVD (mean age 66 years) and without known diabetes at entry to the Heart Outcomes Prevention Evaluation (HOPE) study. During the median 4.5-year follow-up, a diagnosis of diabetes was reported in 261 (4.4%) participants. RESULTS: There was a positive and graded association between increased BMI, waist circumference and waist-to-hip ratio, and the risk of developing diabetes (P for trends <0.0001). After adjusting for all baseline characteristic differences including medications, the relative risk of developing diabetes after the first 40th percentile of each anthropometric measure increased by 12% (95% CI 9% to 15%) for every 1 kg/m2 increase in BMI; the relative risk increased by 5% (95% CI 4% to 6%) for every 1 cm increase in waist circumference and by 38% (95% CI 18% to 61%) for every 0.1 unit increase in waist-to-hip ratio. CONCLUSION: In patients with ICVD, increased BMI, waist-to-hip ratio and particularly waist circumference constitute independent risk factors for development of diabetes. SN - 0828-282X UR - https://www.unboundmedicine.com/medline/citation/14631473/Increased_occurrence_of_diabetes_in_people_with_ischemic_cardiovascular_disease_and_general_and_abdominal_obesity_ L2 - http://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -