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Cutaneous T-cell lymphoma and atopy: is there an association?
Br J Dermatol 2003; 149(5):1013-7BJ

Abstract

BACKGROUND

Case reports have suggested a relationship between atopic diatheses and Sézary syndrome, pre-Sézary syndrome or mycosis fungoides. However, Sézary and pre-Sézary syndromes are rare entities, and this association has never been analysed in greater detail for specific subtypes of cutaneous T-cell lymphoma (CTCL).

OBJECTIVES

To evaluate the prevalence of atopy in subjects with Sézary syndrome, pre-Sézary syndrome or mycosis fungoides, and to compare the rates with the reported prevalence of atopy in the general population.

METHODS

We retrospectively reviewed the records of 157 patients with the diagnosis of Sézary or pre-Sézary syndrome seen between 1965 and 2000, and 102 patients with the diagnosis of mycosis fungoides evaluated from 1994 to 2000 at Mayo Clinic.

RESULTS

Of 157 subjects with Sézary or pre-Sézary syndrome and 102 subjects with mycosis fungoides, 18 and 12, respectively, were identified as having a history of atopic dermatitis, asthma or allergic rhinitis. The prevalence rates of atopy in Sézary or pre-Sézary syndrome and mycosis fungoides were 11.5% (95% confidence interval 6.9-17.5%) and 11.8% (6.2-19.7%), respectively.

CONCLUSIONS

No significant difference exists in the prevalence of atopy in Sézary or pre-Sézary syndrome compared with that in mycosis fungoides (chi2-test, P = 1.00). Furthermore, the rates of atopy in Sézary or pre-Sézary syndrome and mycosis fungoides are not significantly different from the prevalence of atopy in the general population (17-40%). On the basis of these observations, no evidence currently implicates a causal association of CTCL with atopy.

Authors+Show Affiliations

Department of Dermatology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14632807

Citation

Mehrany, K, et al. "Cutaneous T-cell Lymphoma and Atopy: Is There an Association?" The British Journal of Dermatology, vol. 149, no. 5, 2003, pp. 1013-7.
Mehrany K, El-Azhary RA, Bouwhuis SA, et al. Cutaneous T-cell lymphoma and atopy: is there an association? Br J Dermatol. 2003;149(5):1013-7.
Mehrany, K., El-Azhary, R. A., Bouwhuis, S. A., & Pittelkow, M. R. (2003). Cutaneous T-cell lymphoma and atopy: is there an association? The British Journal of Dermatology, 149(5), pp. 1013-7.
Mehrany K, et al. Cutaneous T-cell Lymphoma and Atopy: Is There an Association. Br J Dermatol. 2003;149(5):1013-7. PubMed PMID: 14632807.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cutaneous T-cell lymphoma and atopy: is there an association? AU - Mehrany,K, AU - El-Azhary,R A, AU - Bouwhuis,S A, AU - Pittelkow,M R, PY - 2003/11/25/pubmed PY - 2004/3/19/medline PY - 2003/11/25/entrez SP - 1013 EP - 7 JF - The British journal of dermatology JO - Br. J. Dermatol. VL - 149 IS - 5 N2 - BACKGROUND: Case reports have suggested a relationship between atopic diatheses and Sézary syndrome, pre-Sézary syndrome or mycosis fungoides. However, Sézary and pre-Sézary syndromes are rare entities, and this association has never been analysed in greater detail for specific subtypes of cutaneous T-cell lymphoma (CTCL). OBJECTIVES: To evaluate the prevalence of atopy in subjects with Sézary syndrome, pre-Sézary syndrome or mycosis fungoides, and to compare the rates with the reported prevalence of atopy in the general population. METHODS: We retrospectively reviewed the records of 157 patients with the diagnosis of Sézary or pre-Sézary syndrome seen between 1965 and 2000, and 102 patients with the diagnosis of mycosis fungoides evaluated from 1994 to 2000 at Mayo Clinic. RESULTS: Of 157 subjects with Sézary or pre-Sézary syndrome and 102 subjects with mycosis fungoides, 18 and 12, respectively, were identified as having a history of atopic dermatitis, asthma or allergic rhinitis. The prevalence rates of atopy in Sézary or pre-Sézary syndrome and mycosis fungoides were 11.5% (95% confidence interval 6.9-17.5%) and 11.8% (6.2-19.7%), respectively. CONCLUSIONS: No significant difference exists in the prevalence of atopy in Sézary or pre-Sézary syndrome compared with that in mycosis fungoides (chi2-test, P = 1.00). Furthermore, the rates of atopy in Sézary or pre-Sézary syndrome and mycosis fungoides are not significantly different from the prevalence of atopy in the general population (17-40%). On the basis of these observations, no evidence currently implicates a causal association of CTCL with atopy. SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/14632807/Cutaneous_T_cell_lymphoma_and_atopy:_is_there_an_association L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0007-0963&date=2003&volume=149&issue=5&spage=1013 DB - PRIME DP - Unbound Medicine ER -