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Joint effect of estrogen receptor beta sequence variants and endogenous estrogen exposure on breast cancer risk in Chinese women.
Cancer Res. 2003 Nov 15; 63(22):7624-9.CR

Abstract

Long-term estrogen exposure and family history of breast cancer are the two factors that are most consistently found to be associated with breast cancer risk. Sequence variants in genes involved in estrogen synthesis, metabolism, and signal transduction may account, in part, for this observation. Using data and DNA samples from the Shanghai Breast Cancer Study, we tested the hypothesis that sequence variants of the estrogen receptor beta gene (ESR2) may be associated with increased risk for breast cancer, particularly among women who have a high level and long-term endogenous estrogen exposure. Direct sequencing of the ESR2 gene among 30 Chinese women revealed eight sequence variants. Association analysis of six common sequence variants in 1134 cases and 1235 controls provided evidence for positive associations between breast cancer risk and two single nucleotide polymorphisms (SNPs), [C(14206)T and C(33390)G], among postmenopausal women. Evidence of a stronger association was found for SNP [C(33390)G] among women with a long duration (> or =34 years) of menstruation (odds ratio, 2.37; 95% confidence interval, 1.18-4.77). A potential synergistic effect between SNP [C(33390)G] and several steroid sex hormones was observed, and a 3-4-fold elevated risk of breast cancer was found among women with a CG or GG genotype in SNP [C(33390)G] combined with a high level of steroid sex hormone or a low level of sex hormone binding globulin. Our results are consistent with the hypothesis of a joint effect of estrogen receptor beta sequence variants and endogenous estrogen exposure on breast cancer risk.

Authors+Show Affiliations

Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

14633679

Citation

Zheng, S Lilly, et al. "Joint Effect of Estrogen Receptor Beta Sequence Variants and Endogenous Estrogen Exposure On Breast Cancer Risk in Chinese Women." Cancer Research, vol. 63, no. 22, 2003, pp. 7624-9.
Zheng SL, Zheng W, Chang BL, et al. Joint effect of estrogen receptor beta sequence variants and endogenous estrogen exposure on breast cancer risk in Chinese women. Cancer Res. 2003;63(22):7624-9.
Zheng, S. L., Zheng, W., Chang, B. L., Shu, X. O., Cai, Q., Yu, H., Dai, Q., Xu, J., & Gao, Y. T. (2003). Joint effect of estrogen receptor beta sequence variants and endogenous estrogen exposure on breast cancer risk in Chinese women. Cancer Research, 63(22), 7624-9.
Zheng SL, et al. Joint Effect of Estrogen Receptor Beta Sequence Variants and Endogenous Estrogen Exposure On Breast Cancer Risk in Chinese Women. Cancer Res. 2003 Nov 15;63(22):7624-9. PubMed PMID: 14633679.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Joint effect of estrogen receptor beta sequence variants and endogenous estrogen exposure on breast cancer risk in Chinese women. AU - Zheng,S Lilly, AU - Zheng,Wei, AU - Chang,Bao-li, AU - Shu,Xiao-Ou, AU - Cai,Qiuyin, AU - Yu,Herbert, AU - Dai,Qi, AU - Xu,Jianfeng, AU - Gao,Yu-Tang, PY - 2003/11/25/pubmed PY - 2004/2/11/medline PY - 2003/11/25/entrez SP - 7624 EP - 9 JF - Cancer research JO - Cancer Res VL - 63 IS - 22 N2 - Long-term estrogen exposure and family history of breast cancer are the two factors that are most consistently found to be associated with breast cancer risk. Sequence variants in genes involved in estrogen synthesis, metabolism, and signal transduction may account, in part, for this observation. Using data and DNA samples from the Shanghai Breast Cancer Study, we tested the hypothesis that sequence variants of the estrogen receptor beta gene (ESR2) may be associated with increased risk for breast cancer, particularly among women who have a high level and long-term endogenous estrogen exposure. Direct sequencing of the ESR2 gene among 30 Chinese women revealed eight sequence variants. Association analysis of six common sequence variants in 1134 cases and 1235 controls provided evidence for positive associations between breast cancer risk and two single nucleotide polymorphisms (SNPs), [C(14206)T and C(33390)G], among postmenopausal women. Evidence of a stronger association was found for SNP [C(33390)G] among women with a long duration (> or =34 years) of menstruation (odds ratio, 2.37; 95% confidence interval, 1.18-4.77). A potential synergistic effect between SNP [C(33390)G] and several steroid sex hormones was observed, and a 3-4-fold elevated risk of breast cancer was found among women with a CG or GG genotype in SNP [C(33390)G] combined with a high level of steroid sex hormone or a low level of sex hormone binding globulin. Our results are consistent with the hypothesis of a joint effect of estrogen receptor beta sequence variants and endogenous estrogen exposure on breast cancer risk. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/14633679/Joint_effect_of_estrogen_receptor_beta_sequence_variants_and_endogenous_estrogen_exposure_on_breast_cancer_risk_in_Chinese_women_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=14633679 DB - PRIME DP - Unbound Medicine ER -