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Cobalamin status and its biochemical markers methylmalonic acid and homocysteine in different age groups from 4 days to 19 years.
Clin Chem. 2003 Dec; 49(12):2067-75.CC

Abstract

BACKGROUND

Recent data indicate that cobalamin and folate status, including the metabolic markers methylmalonic acid (MMA) and total homocysteine (tHcy), undergo marked changes during childhood, particularly during the first year.

METHODS

Serum cobalamin, serum and whole-blood folate, and plasma MMA and tHcy were determined in a cross-sectional study of 700 children, ages 4 days to 19 years.

RESULTS

During the first 6 months, serum cobalamin was lower than and plasma MMA, tHcy, and serum folate were higher than the concentrations detected in the other age groups. In infants 6 weeks to 6 months of age, median MMA and tHcy concentrations were >0.78 and >75 micro mol/L, respectively. In older children (>6 months), serum cobalamin peaked at 3-7 years and then decreased, median plasma MMA remained low (<0.26 micro mol/L), median plasma tHcy was low (<6 micro mol/L) and increased from the age of 7 years on, and serum folate gradually decreased. Plasma MMA was inversely associated with cobalamin (r = -0.4) in both age groups, but across the whole range of cobalamin concentrations, MMA was markedly higher in infants (< or =6 months) than in older children. Plasma tHcy showed a strong negative correlation to cobalamin (r = -0.52) but not to serum folate in infants < or =6 months. In older children, tHcy showed the expected association with both cobalamin (r = -0.48) and folate (r = -0.51).

CONCLUSIONS

In infants 6 weeks to 6 months, concentrations of the metabolic markers MMA and tHcy were higher than in the other age groups and strongly correlated to cobalamin, whereas in older children, both makers showed correlations to cobalamin and folate concentrations documented in adults. Whether this metabolic profile in infants is explained by impaired cobalamin status, which in turn may have long-term effects on psychomotor development, remains to be addressed in intervention studies.

Authors+Show Affiliations

Department of Pediatrics, University of Bergen, N-5021 Bergen, Norway.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14633879

Citation

Monsen, Anne-Lise Bjørke, et al. "Cobalamin Status and Its Biochemical Markers Methylmalonic Acid and Homocysteine in Different Age Groups From 4 Days to 19 Years." Clinical Chemistry, vol. 49, no. 12, 2003, pp. 2067-75.
Monsen AL, Refsum H, Markestad T, et al. Cobalamin status and its biochemical markers methylmalonic acid and homocysteine in different age groups from 4 days to 19 years. Clin Chem. 2003;49(12):2067-75.
Monsen, A. L., Refsum, H., Markestad, T., & Ueland, P. M. (2003). Cobalamin status and its biochemical markers methylmalonic acid and homocysteine in different age groups from 4 days to 19 years. Clinical Chemistry, 49(12), 2067-75.
Monsen AL, et al. Cobalamin Status and Its Biochemical Markers Methylmalonic Acid and Homocysteine in Different Age Groups From 4 Days to 19 Years. Clin Chem. 2003;49(12):2067-75. PubMed PMID: 14633879.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cobalamin status and its biochemical markers methylmalonic acid and homocysteine in different age groups from 4 days to 19 years. AU - Monsen,Anne-Lise Bjørke, AU - Refsum,Helga, AU - Markestad,Trond, AU - Ueland,Per Magne, PY - 2003/11/25/pubmed PY - 2003/12/20/medline PY - 2003/11/25/entrez SP - 2067 EP - 75 JF - Clinical chemistry JO - Clin Chem VL - 49 IS - 12 N2 - BACKGROUND: Recent data indicate that cobalamin and folate status, including the metabolic markers methylmalonic acid (MMA) and total homocysteine (tHcy), undergo marked changes during childhood, particularly during the first year. METHODS: Serum cobalamin, serum and whole-blood folate, and plasma MMA and tHcy were determined in a cross-sectional study of 700 children, ages 4 days to 19 years. RESULTS: During the first 6 months, serum cobalamin was lower than and plasma MMA, tHcy, and serum folate were higher than the concentrations detected in the other age groups. In infants 6 weeks to 6 months of age, median MMA and tHcy concentrations were >0.78 and >75 micro mol/L, respectively. In older children (>6 months), serum cobalamin peaked at 3-7 years and then decreased, median plasma MMA remained low (<0.26 micro mol/L), median plasma tHcy was low (<6 micro mol/L) and increased from the age of 7 years on, and serum folate gradually decreased. Plasma MMA was inversely associated with cobalamin (r = -0.4) in both age groups, but across the whole range of cobalamin concentrations, MMA was markedly higher in infants (< or =6 months) than in older children. Plasma tHcy showed a strong negative correlation to cobalamin (r = -0.52) but not to serum folate in infants < or =6 months. In older children, tHcy showed the expected association with both cobalamin (r = -0.48) and folate (r = -0.51). CONCLUSIONS: In infants 6 weeks to 6 months, concentrations of the metabolic markers MMA and tHcy were higher than in the other age groups and strongly correlated to cobalamin, whereas in older children, both makers showed correlations to cobalamin and folate concentrations documented in adults. Whether this metabolic profile in infants is explained by impaired cobalamin status, which in turn may have long-term effects on psychomotor development, remains to be addressed in intervention studies. SN - 0009-9147 UR - https://www.unboundmedicine.com/medline/citation/14633879/Cobalamin_status_and_its_biochemical_markers_methylmalonic_acid_and_homocysteine_in_different_age_groups_from_4_days_to_19_years_ L2 - https://academic.oup.com/clinchem/article-lookup/doi/10.1373/clinchem.2003.019869 DB - PRIME DP - Unbound Medicine ER -