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Relationship between thrombopoietin serum levels and liver function in patients with chronic liver disease related to hepatitis C virus infection.
Am J Gastroenterol. 2003 Nov; 98(11):2516-20.AJ

Abstract

OBJECTIVES

Thrombopoietin (Tpo) is an important regulator of megakaryocyte maturation and platelet production, and is mainly produced by the liver. A decrease in Tpo production is partly responsible for the thrombocytopenia observed in patients with chronic liver disease (CLD). The aim of this study was to evaluate the relationship between Tpo serum levels and liver function in patients with CLD related to hepatitis C virus (HCV) infection.

METHODS

We studied 37 patients with various degrees of HCV-related CLD. Of the patients, 17 had chronic hepatitis and 20 liver cirrhosis. Liver function was evaluated in all patients by the following hepatic blood flow dependent and independent tests that explore various hepatic metabolic functions: carbon-13 (13C)-aminopyrine breath test (13C-ABT), 13C-galactose breath test (13C-GBT), and monoethylglycinexylidide (MEGX) test. Liver function tests results were correlated with Tpo serum levels.

RESULTS

Tpo serum levels were significantly lower in patients with liver cirrhosis (88 +/- 23 pg/ml) as compared to those in patients with chronic hepatitis (128 +/- 55 pg/ml, p=0.0031). However, they did not correlate with serum albumin, bilirubin, or prothrombin activity. Tpo serum levels showed a significant positive correlation with 13C-ABT results (hourly dose at 30 min, rs=0.489, p=0.002; cumulative dose at 120 min, rs=0.425, p=0.008). Moreover, they showed a fair, positive correlation with 13C-GBT hourly dose at 30 min (rs=0.366, p=0.028), and a trend toward a positive correlation with the various MEGX test sampling times (MEGX15, rs=0.314, p=0.059; MEGX30, rs=0.284, p=0.088; and MEGX60, rs=0.320, p=0.059).

CONCLUSIONS

In this study we have shown that a progressive decline in liver function in patients with HCV-related CLD is paralleled by a decrease in Tpo production. The different correlations observed between Tpo and the various liver function tests suggests that this finding is mainly the result of a decrease in hepatic functional mass rather than dependent on alteration in splanchnic hemodynamic.

Authors+Show Affiliations

Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Genoa, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

14638357

Citation

Giannini, Edoardo, et al. "Relationship Between Thrombopoietin Serum Levels and Liver Function in Patients With Chronic Liver Disease Related to Hepatitis C Virus Infection." The American Journal of Gastroenterology, vol. 98, no. 11, 2003, pp. 2516-20.
Giannini E, Botta F, Borro P, et al. Relationship between thrombopoietin serum levels and liver function in patients with chronic liver disease related to hepatitis C virus infection. Am J Gastroenterol. 2003;98(11):2516-20.
Giannini, E., Botta, F., Borro, P., Malfatti, F., Fumagalli, A., Testa, E., Podestà, E., Chiarbonello, B., Polegato, S., Mamone, M., & Testa, R. (2003). Relationship between thrombopoietin serum levels and liver function in patients with chronic liver disease related to hepatitis C virus infection. The American Journal of Gastroenterology, 98(11), 2516-20.
Giannini E, et al. Relationship Between Thrombopoietin Serum Levels and Liver Function in Patients With Chronic Liver Disease Related to Hepatitis C Virus Infection. Am J Gastroenterol. 2003;98(11):2516-20. PubMed PMID: 14638357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between thrombopoietin serum levels and liver function in patients with chronic liver disease related to hepatitis C virus infection. AU - Giannini,Edoardo, AU - Botta,Federica, AU - Borro,Paolo, AU - Malfatti,Federica, AU - Fumagalli,Alessandra, AU - Testa,Emanuela, AU - Podestà,Elena, AU - Chiarbonello,Bruno, AU - Polegato,Simone, AU - Mamone,Mario, AU - Testa,Roberto, PY - 2003/11/26/pubmed PY - 2004/1/6/medline PY - 2003/11/26/entrez SP - 2516 EP - 20 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 98 IS - 11 N2 - OBJECTIVES: Thrombopoietin (Tpo) is an important regulator of megakaryocyte maturation and platelet production, and is mainly produced by the liver. A decrease in Tpo production is partly responsible for the thrombocytopenia observed in patients with chronic liver disease (CLD). The aim of this study was to evaluate the relationship between Tpo serum levels and liver function in patients with CLD related to hepatitis C virus (HCV) infection. METHODS: We studied 37 patients with various degrees of HCV-related CLD. Of the patients, 17 had chronic hepatitis and 20 liver cirrhosis. Liver function was evaluated in all patients by the following hepatic blood flow dependent and independent tests that explore various hepatic metabolic functions: carbon-13 (13C)-aminopyrine breath test (13C-ABT), 13C-galactose breath test (13C-GBT), and monoethylglycinexylidide (MEGX) test. Liver function tests results were correlated with Tpo serum levels. RESULTS: Tpo serum levels were significantly lower in patients with liver cirrhosis (88 +/- 23 pg/ml) as compared to those in patients with chronic hepatitis (128 +/- 55 pg/ml, p=0.0031). However, they did not correlate with serum albumin, bilirubin, or prothrombin activity. Tpo serum levels showed a significant positive correlation with 13C-ABT results (hourly dose at 30 min, rs=0.489, p=0.002; cumulative dose at 120 min, rs=0.425, p=0.008). Moreover, they showed a fair, positive correlation with 13C-GBT hourly dose at 30 min (rs=0.366, p=0.028), and a trend toward a positive correlation with the various MEGX test sampling times (MEGX15, rs=0.314, p=0.059; MEGX30, rs=0.284, p=0.088; and MEGX60, rs=0.320, p=0.059). CONCLUSIONS: In this study we have shown that a progressive decline in liver function in patients with HCV-related CLD is paralleled by a decrease in Tpo production. The different correlations observed between Tpo and the various liver function tests suggests that this finding is mainly the result of a decrease in hepatic functional mass rather than dependent on alteration in splanchnic hemodynamic. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/14638357/Relationship_between_thrombopoietin_serum_levels_and_liver_function_in_patients_with_chronic_liver_disease_related_to_hepatitis_C_virus_infection_ L2 - https://Insights.ovid.com/pubmed?pmid=14638357 DB - PRIME DP - Unbound Medicine ER -