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[Serum cannabinoid levels 24 to 48 hours after cannabis smoking].
Arch Kriminol. 2003 Sep-Oct; 212(3-4):83-95.AK

Abstract

Low concentrations of THC and 11-hydroxy-THC in serum samples are often claimed not to result from recent cannabis use. Prediction of time of exposure is difficult, especially if distinctive features of drug use could not be observed. Therefore, the aim of the study was to investigate the presence of THC and 11-hydroxy-THC in serum samples as well as to obtain preliminary data on the analyte profile for a time window of 24-48 hours after discontinuation of cannabis smoking. Serum samples from heavy (n = 12, > 1 joint/day), moderate (n = 11, < or = 1 joint/day) and light (n = 6, < 1 joint/week) smokers of cannabis were analyzed for THC, 11-hydroxy-THC and free THC-COOH by GC/MS as well as for glucuronidated THC-COOH by LC/MS-MS. The blood samples were collected 24-48 hours after abstaining from cannabis use. Additionally, 8 specimens were obtained from persons after discontinuation of the drug for more than 48 hours. During collection of the blood samples, distinctive effects due to drug use could not be observed. For heavy users of cannabis, THC was detectable in 8 samples, and in 5 cases both biologically active compounds, THC and 11-hydroxy-THC, were present (1.3-6.4 ng THC/mL serum, 0.5-2.4 ng 11-hydroxy-THC/mL serum). Among moderate users, in 1 sample 1.8 ng THC/mL serum and 1.3 ng 11-hydroxy-THC/mL serum were determined, and another sample was tested positive with low concentrations close to the limit of detection. In serum samples of light users both analytes could not be detected, indicating that in those persons a positive finding of THC and 11-hydroxy-THC may rather result from recent consumption than from cannabis use 1 or 2 days prior to blood sampling. The concentrations of THC-COOH and its glucuronide covered a wide range in all groups of cannabis users. However, there was a trend to higher concentrations in heavy users compared to moderate users, and the mean concentration was smaller in light smokers than in moderate smokers. Overall, the findings indicated that data from pharmacokinetic studies should be supplemented by data obtained from "real-life" samples.

Authors+Show Affiliations

Institut für Rechts- und Verkehrsmedizin, Universität Heidelberg.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

ger

PubMed ID

14639811

Citation

Skopp, Gisela, et al. "[Serum Cannabinoid Levels 24 to 48 Hours After Cannabis Smoking]." Archiv Fur Kriminologie, vol. 212, no. 3-4, 2003, pp. 83-95.
Skopp G, Richter B, Pötsch L. [Serum cannabinoid levels 24 to 48 hours after cannabis smoking]. Arch Kriminol. 2003;212(3-4):83-95.
Skopp, G., Richter, B., & Pötsch, L. (2003). [Serum cannabinoid levels 24 to 48 hours after cannabis smoking]. Archiv Fur Kriminologie, 212(3-4), 83-95.
Skopp G, Richter B, Pötsch L. [Serum Cannabinoid Levels 24 to 48 Hours After Cannabis Smoking]. Arch Kriminol. 2003 Sep-Oct;212(3-4):83-95. PubMed PMID: 14639811.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Serum cannabinoid levels 24 to 48 hours after cannabis smoking]. AU - Skopp,Gisela, AU - Richter,Barbara, AU - Pötsch,Lucia, PY - 2003/12/3/pubmed PY - 2004/3/30/medline PY - 2003/12/3/entrez SP - 83 EP - 95 JF - Archiv fur Kriminologie JO - Arch Kriminol VL - 212 IS - 3-4 N2 - Low concentrations of THC and 11-hydroxy-THC in serum samples are often claimed not to result from recent cannabis use. Prediction of time of exposure is difficult, especially if distinctive features of drug use could not be observed. Therefore, the aim of the study was to investigate the presence of THC and 11-hydroxy-THC in serum samples as well as to obtain preliminary data on the analyte profile for a time window of 24-48 hours after discontinuation of cannabis smoking. Serum samples from heavy (n = 12, > 1 joint/day), moderate (n = 11, < or = 1 joint/day) and light (n = 6, < 1 joint/week) smokers of cannabis were analyzed for THC, 11-hydroxy-THC and free THC-COOH by GC/MS as well as for glucuronidated THC-COOH by LC/MS-MS. The blood samples were collected 24-48 hours after abstaining from cannabis use. Additionally, 8 specimens were obtained from persons after discontinuation of the drug for more than 48 hours. During collection of the blood samples, distinctive effects due to drug use could not be observed. For heavy users of cannabis, THC was detectable in 8 samples, and in 5 cases both biologically active compounds, THC and 11-hydroxy-THC, were present (1.3-6.4 ng THC/mL serum, 0.5-2.4 ng 11-hydroxy-THC/mL serum). Among moderate users, in 1 sample 1.8 ng THC/mL serum and 1.3 ng 11-hydroxy-THC/mL serum were determined, and another sample was tested positive with low concentrations close to the limit of detection. In serum samples of light users both analytes could not be detected, indicating that in those persons a positive finding of THC and 11-hydroxy-THC may rather result from recent consumption than from cannabis use 1 or 2 days prior to blood sampling. The concentrations of THC-COOH and its glucuronide covered a wide range in all groups of cannabis users. However, there was a trend to higher concentrations in heavy users compared to moderate users, and the mean concentration was smaller in light smokers than in moderate smokers. Overall, the findings indicated that data from pharmacokinetic studies should be supplemented by data obtained from "real-life" samples. SN - 0003-9225 UR - https://www.unboundmedicine.com/medline/citation/14639811/[Serum_cannabinoid_levels_24_to_48_hours_after_cannabis_smoking]_ L2 - http://www.diseaseinfosearch.org/result/45 DB - PRIME DP - Unbound Medicine ER -