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Plasma magnesium in adult asthmatics at the Lagos University Teaching Hospital, Nigeria.
East Afr Med J. 2003 Sep; 80(9):488-91.EA

Abstract

OBJECTIVE

To determine the plasma magnesium levels in adult asthmatics.

DESIGN

Case control study.

SETTING

Lagos University Teaching Hospital, Lagos, Nigeria.

SUBJECTS

Forty stable asthmatics and thirty five apparently healthy controls.

METHODS

Detailed history including drug history was obtained from patients and controls. Fasting venous blood was collected into heparinized tubes from both patients and controls. Plasma magnesium, albumin, calcium and phosphorus were measured using spectrophotometric end point methods.

RESULTS

Mean (SD) plasma magnesium concentration of 0.93(0.24) mmol/L in the asthmatics was significantly lower compared to the controls which was 1.15(0.28) mmol/L, p<0.001. There was no significant difference in the plasma albumin, calcium and phosphorus levels between the patients and controls. Plasma magnesium levels correlated with the plasma albumin level (r=0.62) but did not correlate with the duration of disease, peak flow rate and age of patients. There was no gender difference in plasma magnesium levels in the asthmatics.

CONCLUSION

Adult Nigerian asthmatics have lower plasma magnesium concentrations compared to healthy controls. This may be of use in future therapeutic management of asthma. A large scale multi-centre study needs to be carried out since this study was done in one hospital.

Authors+Show Affiliations

Department of Clinical Pathology, College of Medicine, University of Lagos, Lagos University Teaching Hospital, Lagos, Nigeria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14640172

Citation

Oladipo, O O., et al. "Plasma Magnesium in Adult Asthmatics at the Lagos University Teaching Hospital, Nigeria." East African Medical Journal, vol. 80, no. 9, 2003, pp. 488-91.
Oladipo OO, Chukwu CC, Ajala MO, et al. Plasma magnesium in adult asthmatics at the Lagos University Teaching Hospital, Nigeria. East Afr Med J. 2003;80(9):488-91.
Oladipo, O. O., Chukwu, C. C., Ajala, M. O., Adewole, T. A., & Afonja, O. A. (2003). Plasma magnesium in adult asthmatics at the Lagos University Teaching Hospital, Nigeria. East African Medical Journal, 80(9), 488-91.
Oladipo OO, et al. Plasma Magnesium in Adult Asthmatics at the Lagos University Teaching Hospital, Nigeria. East Afr Med J. 2003;80(9):488-91. PubMed PMID: 14640172.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma magnesium in adult asthmatics at the Lagos University Teaching Hospital, Nigeria. AU - Oladipo,O O, AU - Chukwu,C C, AU - Ajala,M O, AU - Adewole,T A, AU - Afonja,O A, PY - 2003/12/3/pubmed PY - 2004/1/16/medline PY - 2003/12/3/entrez SP - 488 EP - 91 JF - East African medical journal JO - East Afr Med J VL - 80 IS - 9 N2 - OBJECTIVE: To determine the plasma magnesium levels in adult asthmatics. DESIGN: Case control study. SETTING: Lagos University Teaching Hospital, Lagos, Nigeria. SUBJECTS: Forty stable asthmatics and thirty five apparently healthy controls. METHODS: Detailed history including drug history was obtained from patients and controls. Fasting venous blood was collected into heparinized tubes from both patients and controls. Plasma magnesium, albumin, calcium and phosphorus were measured using spectrophotometric end point methods. RESULTS: Mean (SD) plasma magnesium concentration of 0.93(0.24) mmol/L in the asthmatics was significantly lower compared to the controls which was 1.15(0.28) mmol/L, p<0.001. There was no significant difference in the plasma albumin, calcium and phosphorus levels between the patients and controls. Plasma magnesium levels correlated with the plasma albumin level (r=0.62) but did not correlate with the duration of disease, peak flow rate and age of patients. There was no gender difference in plasma magnesium levels in the asthmatics. CONCLUSION: Adult Nigerian asthmatics have lower plasma magnesium concentrations compared to healthy controls. This may be of use in future therapeutic management of asthma. A large scale multi-centre study needs to be carried out since this study was done in one hospital. SN - 0012-835X UR - https://www.unboundmedicine.com/medline/citation/14640172/Plasma_magnesium_in_adult_asthmatics_at_the_Lagos_University_Teaching_Hospital_Nigeria_ L2 - https://medlineplus.gov/asthma.html DB - PRIME DP - Unbound Medicine ER -