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New polyoxygenated farnesylcyclohexenones, deacetoxyyanuthone A and its hydro derivative from the marine-derived fungus Penicillium sp.
J Nat Prod. 2003 Nov; 66(11):1499-500.JN

Abstract

New polyoxygenated farnesylcyclohexenones, 7-deacetoxyyanuthone A (1) and its 2,3-hydro derivative (2), were isolated together with the known farnesylquinones (3, 4) from a marine isolate of the genus Penicillium. The structures of the new deacetoxyyanuthone A (1) and its 2,3-hydro derivative (2) were assigned by spectroscopic methods, including 2D NMR and CD for the Cotton effect of alpha-epoxyketone experiments. Compounds 1 and 3 showed moderate in vitro cytotoxicity in a panel of five human tumor cell lines, and 1 also exhibited mild in vitro antibacterial activity against methicillin-resistant and multidrug-resistant Staphylococcus aureus (MIC, 50 microg/mL).

Authors+Show Affiliations

Li X
Department of Chemistry, Pukyong National University, Busan 608-737, Korea.
Choi HD
No affiliation info available
Kang JS
No affiliation info available
Lee CO
No affiliation info available
Son BW
No affiliation info available

MeSH

Anti-Bacterial AgentsCyclohexanesFarnesolKoreaMethicillin ResistanceMicrobial Sensitivity TestsMolecular StructureNuclear Magnetic Resonance, BiomolecularPenicilliumStaphylococcus aureus

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14640527

Citation

Li, Xifeng, et al. "New Polyoxygenated Farnesylcyclohexenones, Deacetoxyyanuthone a and Its Hydro Derivative From the Marine-derived Fungus Penicillium Sp." Journal of Natural Products, vol. 66, no. 11, 2003, pp. 1499-500.
Li X, Choi HD, Kang JS, et al. New polyoxygenated farnesylcyclohexenones, deacetoxyyanuthone A and its hydro derivative from the marine-derived fungus Penicillium sp. J Nat Prod. 2003;66(11):1499-500.
Li, X., Choi, H. D., Kang, J. S., Lee, C. O., & Son, B. W. (2003). New polyoxygenated farnesylcyclohexenones, deacetoxyyanuthone A and its hydro derivative from the marine-derived fungus Penicillium sp. Journal of Natural Products, 66(11), 1499-500.
Li X, et al. New Polyoxygenated Farnesylcyclohexenones, Deacetoxyyanuthone a and Its Hydro Derivative From the Marine-derived Fungus Penicillium Sp. J Nat Prod. 2003;66(11):1499-500. PubMed PMID: 14640527.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New polyoxygenated farnesylcyclohexenones, deacetoxyyanuthone A and its hydro derivative from the marine-derived fungus Penicillium sp. AU - Li,Xifeng, AU - Choi,Hong Dae, AU - Kang,Jung Sook, AU - Lee,Chong-O, AU - Son,Byeng Wha, PY - 2003/12/3/pubmed PY - 2004/3/12/medline PY - 2003/12/3/entrez SP - 1499 EP - 500 JF - Journal of natural products JO - J Nat Prod VL - 66 IS - 11 N2 - New polyoxygenated farnesylcyclohexenones, 7-deacetoxyyanuthone A (1) and its 2,3-hydro derivative (2), were isolated together with the known farnesylquinones (3, 4) from a marine isolate of the genus Penicillium. The structures of the new deacetoxyyanuthone A (1) and its 2,3-hydro derivative (2) were assigned by spectroscopic methods, including 2D NMR and CD for the Cotton effect of alpha-epoxyketone experiments. Compounds 1 and 3 showed moderate in vitro cytotoxicity in a panel of five human tumor cell lines, and 1 also exhibited mild in vitro antibacterial activity against methicillin-resistant and multidrug-resistant Staphylococcus aureus (MIC, 50 microg/mL). SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/14640527/New_polyoxygenated_farnesylcyclohexenones_deacetoxyyanuthone_A_and_its_hydro_derivative_from_the_marine_derived_fungus_Penicillium_sp_ DB - PRIME DP - Unbound Medicine ER -