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[Detection of cytomegalovirus infection by polymerase chain reaction in hematopoietic stem cell transplantation recipients].
Zhonghua Xue Ye Xue Za Zhi. 2003 Aug; 24(8):407-9.ZX

Abstract

OBJECTIVE

To evaluate the detection of cytomegalovirus (CMV) by polymerase chain reaction (PCR) for predicting the development of CMV disease.

METHODS

One hundred and thirty one allo-HSCT patients performed in the past 2 years were analyzed retrospectively. PCR-CMV was used to monitor CMV viremia and vireuria once a week after transplantation.

RESULTS

In the dynamic detection, CMV viremia was positive for at least one chance in 89 patients, vireuria did in 99 patients. Thirty-seven patients developed CMV disease with an accumulative incidence of 32.5%. The incidence of CMV disease was 15.6% in plasma CMV-PCR negative group, 31.3% in positive once group, and 47.3% in positive over twice group. There was significant difference among the three groups (P = 0.0126). The incidence of CMV disease was 24.8% in urine CMV-PCR negative group, 43.5% in positive once group, and 33.0% in positive over twice group, being no significant difference among them (P = 0.845). On analysis, viremia could predict the development of CMV disease: the PPV (positive predictive value) is 40.5%, NPV (negative predictive value) is 84.4%, sensitivity is 75.0%, and specificity is 69.2%.

CONCLUSIONS

Detected by CMV-PCR, MCV viremia may predict the development of CMV disease, but MCV vireuria cannot.

Authors+Show Affiliations

Institute of Hematology, People's Hospital, Peking University, Beijing 100044, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

14642176

Citation

Xu, Lan-ping, et al. "[Detection of Cytomegalovirus Infection By Polymerase Chain Reaction in Hematopoietic Stem Cell Transplantation Recipients]." Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi, vol. 24, no. 8, 2003, pp. 407-9.
Xu LP, Huang XJ, Guo NL, et al. [Detection of cytomegalovirus infection by polymerase chain reaction in hematopoietic stem cell transplantation recipients]. Zhonghua Xue Ye Xue Za Zhi. 2003;24(8):407-9.
Xu, L. P., Huang, X. J., Guo, N. L., Ren, H. Y., Zhang, Y. C., & Lu, D. P. (2003). [Detection of cytomegalovirus infection by polymerase chain reaction in hematopoietic stem cell transplantation recipients]. Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi, 24(8), 407-9.
Xu LP, et al. [Detection of Cytomegalovirus Infection By Polymerase Chain Reaction in Hematopoietic Stem Cell Transplantation Recipients]. Zhonghua Xue Ye Xue Za Zhi. 2003;24(8):407-9. PubMed PMID: 14642176.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Detection of cytomegalovirus infection by polymerase chain reaction in hematopoietic stem cell transplantation recipients]. AU - Xu,Lan-ping, AU - Huang,Xiao-jun, AU - Guo,Nai-lan, AU - Ren,Han-yun, AU - Zhang,Yao-chen, AU - Lu,Dao-pei, PY - 2003/12/4/pubmed PY - 2007/5/23/medline PY - 2003/12/4/entrez SP - 407 EP - 9 JF - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi JO - Zhonghua Xue Ye Xue Za Zhi VL - 24 IS - 8 N2 - OBJECTIVE: To evaluate the detection of cytomegalovirus (CMV) by polymerase chain reaction (PCR) for predicting the development of CMV disease. METHODS: One hundred and thirty one allo-HSCT patients performed in the past 2 years were analyzed retrospectively. PCR-CMV was used to monitor CMV viremia and vireuria once a week after transplantation. RESULTS: In the dynamic detection, CMV viremia was positive for at least one chance in 89 patients, vireuria did in 99 patients. Thirty-seven patients developed CMV disease with an accumulative incidence of 32.5%. The incidence of CMV disease was 15.6% in plasma CMV-PCR negative group, 31.3% in positive once group, and 47.3% in positive over twice group. There was significant difference among the three groups (P = 0.0126). The incidence of CMV disease was 24.8% in urine CMV-PCR negative group, 43.5% in positive once group, and 33.0% in positive over twice group, being no significant difference among them (P = 0.845). On analysis, viremia could predict the development of CMV disease: the PPV (positive predictive value) is 40.5%, NPV (negative predictive value) is 84.4%, sensitivity is 75.0%, and specificity is 69.2%. CONCLUSIONS: Detected by CMV-PCR, MCV viremia may predict the development of CMV disease, but MCV vireuria cannot. SN - 0253-2727 UR - https://www.unboundmedicine.com/medline/citation/14642176/[Detection_of_cytomegalovirus_infection_by_polymerase_chain_reaction_in_hematopoietic_stem_cell_transplantation_recipients]_ L2 - http://www.diseaseinfosearch.org/result/7171 DB - PRIME DP - Unbound Medicine ER -