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Acute effects of 3,4-methylenedioxymethamphetamine on striatal single-unit activity and behavior in freely moving rats: differential involvement of dopamine D(1) and D(2) receptors.
Brain Res. 2003 Dec 24; 994(2):203-15.BR

Abstract

3,4-Methylenedioxymethamphetamine (MDMA) is a widely abused amphetamine derivative that increases dopamine (DA) and serotonin release via a reverse transport mechanism. Changes in the activity of striatal neurons in response to increased DA transmission may shape the behavioral patterns associated with amphetamine-like stimulants. To determine how the striatum participates in MDMA-induced locomotor activation, we recorded the activity of >100 single units in the striatum of freely moving rats in response to a dose that increased motor activation (5.0 mg/kg). MDMA had a predominantly excitatory effect on neuronal activity that was positively correlated with the magnitude of locomotor activation. Categorizing neurons according to baseline locomotor responsiveness revealed that MDMA excited significantly more neurons showing movement-related increases in activity compared to units that were non-movement-related or associated with movement-related decreases in activity. Further analysis revealed that the drug-induced striatal activation was not simply secondary to the behavioral change, indicating a primary action of MDMA on striatal motor circuits. Prior administration of SCH-23390 (0.2 mg/kg), a D(1) antagonist, resulted in a late onset of MDMA-induced locomotion, which correlated positively with delayed neuronal excitations. Conversely, prior administration of eticlopride (0.2 mg/kg), a D(2) antagonist, completely abolished MDMA-induced locomotion, which paralleled its blockade of MDMA-induced excitatory neuronal responses. Our results highlight the importance of striatal neuronal activity in shaping the behavioral response to MDMA, and suggest that DA D(1) and D(2) receptors have distinct functional roles in the expression of MDMA-induced striatal and locomotor activation.

Authors+Show Affiliations

Department of Psychology and Program in Neural Science, Psychology Building, Indiana University, 1101 East 10th Street, Bloomington, IN 47405-7007, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

14642646

Citation

Ball, Kevin T., et al. "Acute Effects of 3,4-methylenedioxymethamphetamine On Striatal Single-unit Activity and Behavior in Freely Moving Rats: Differential Involvement of Dopamine D(1) and D(2) Receptors." Brain Research, vol. 994, no. 2, 2003, pp. 203-15.
Ball KT, Budreau D, Rebec GV. Acute effects of 3,4-methylenedioxymethamphetamine on striatal single-unit activity and behavior in freely moving rats: differential involvement of dopamine D(1) and D(2) receptors. Brain Res. 2003;994(2):203-15.
Ball, K. T., Budreau, D., & Rebec, G. V. (2003). Acute effects of 3,4-methylenedioxymethamphetamine on striatal single-unit activity and behavior in freely moving rats: differential involvement of dopamine D(1) and D(2) receptors. Brain Research, 994(2), 203-15.
Ball KT, Budreau D, Rebec GV. Acute Effects of 3,4-methylenedioxymethamphetamine On Striatal Single-unit Activity and Behavior in Freely Moving Rats: Differential Involvement of Dopamine D(1) and D(2) Receptors. Brain Res. 2003 Dec 24;994(2):203-15. PubMed PMID: 14642646.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute effects of 3,4-methylenedioxymethamphetamine on striatal single-unit activity and behavior in freely moving rats: differential involvement of dopamine D(1) and D(2) receptors. AU - Ball,Kevin T, AU - Budreau,Daniel, AU - Rebec,George V, PY - 2003/12/4/pubmed PY - 2004/1/30/medline PY - 2003/12/4/entrez SP - 203 EP - 15 JF - Brain research JO - Brain Res. VL - 994 IS - 2 N2 - 3,4-Methylenedioxymethamphetamine (MDMA) is a widely abused amphetamine derivative that increases dopamine (DA) and serotonin release via a reverse transport mechanism. Changes in the activity of striatal neurons in response to increased DA transmission may shape the behavioral patterns associated with amphetamine-like stimulants. To determine how the striatum participates in MDMA-induced locomotor activation, we recorded the activity of >100 single units in the striatum of freely moving rats in response to a dose that increased motor activation (5.0 mg/kg). MDMA had a predominantly excitatory effect on neuronal activity that was positively correlated with the magnitude of locomotor activation. Categorizing neurons according to baseline locomotor responsiveness revealed that MDMA excited significantly more neurons showing movement-related increases in activity compared to units that were non-movement-related or associated with movement-related decreases in activity. Further analysis revealed that the drug-induced striatal activation was not simply secondary to the behavioral change, indicating a primary action of MDMA on striatal motor circuits. Prior administration of SCH-23390 (0.2 mg/kg), a D(1) antagonist, resulted in a late onset of MDMA-induced locomotion, which correlated positively with delayed neuronal excitations. Conversely, prior administration of eticlopride (0.2 mg/kg), a D(2) antagonist, completely abolished MDMA-induced locomotion, which paralleled its blockade of MDMA-induced excitatory neuronal responses. Our results highlight the importance of striatal neuronal activity in shaping the behavioral response to MDMA, and suggest that DA D(1) and D(2) receptors have distinct functional roles in the expression of MDMA-induced striatal and locomotor activation. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/14642646/Acute_effects_of_34_methylenedioxymethamphetamine_on_striatal_single_unit_activity_and_behavior_in_freely_moving_rats:_differential_involvement_of_dopamine_D_1__and_D_2__receptors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006899303037557 DB - PRIME DP - Unbound Medicine ER -