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Combination of microdialysis and glucosensor permits continuous (on line) SC glucose monitoring in a patient operated device. II. Evaluation in animals.
Horm Metab Res. 1992 Oct; 24(10):492-3.HM

Abstract

The microdialysis technique was used for following the glucose content of the extracellular subcutaneous (SC) fluid under varying blood glucose levels in rats. The glucose content in the microdialysis perfusion fluid was continuously analyzed by means of the measuring flow chamber of an ex vivo glucose monitor. In six ChBB rats blood glucose levels were varied between 40 mg/dl and 575 mg/dl by intravenous (IV) infusion of glucose and by SC injections of insulin, respectively. After a running-in period of about half an hour, the glucose content in the perfusion fluid was closely related to the blood glucose concentration (r > 0.92) up to a time period of 6 hrs. The "relative recovery" rate of glucose by the microdialysis probe in the SC tissue varied within the 6 experimental sessions. The relative recovery rate could be shown to be not dependent on the absolute blood glucose levels in the individual rat within the glucose concentration range tested.

Authors+Show Affiliations

Abteilung Innere Medizin, Universität Ulm, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1464417

Citation

Keck, F S., et al. "Combination of Microdialysis and Glucosensor Permits Continuous (on Line) SC Glucose Monitoring in a Patient Operated Device. II. Evaluation in Animals." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 24, no. 10, 1992, pp. 492-3.
Keck FS, Meyerhoff C, Kerner W, et al. Combination of microdialysis and glucosensor permits continuous (on line) SC glucose monitoring in a patient operated device. II. Evaluation in animals. Horm Metab Res. 1992;24(10):492-3.
Keck, F. S., Meyerhoff, C., Kerner, W., Siegmund, T., Zier, H., & Pfeiffer, E. F. (1992). Combination of microdialysis and glucosensor permits continuous (on line) SC glucose monitoring in a patient operated device. II. Evaluation in animals. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 24(10), 492-3.
Keck FS, et al. Combination of Microdialysis and Glucosensor Permits Continuous (on Line) SC Glucose Monitoring in a Patient Operated Device. II. Evaluation in Animals. Horm Metab Res. 1992;24(10):492-3. PubMed PMID: 1464417.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combination of microdialysis and glucosensor permits continuous (on line) SC glucose monitoring in a patient operated device. II. Evaluation in animals. AU - Keck,F S, AU - Meyerhoff,C, AU - Kerner,W, AU - Siegmund,T, AU - Zier,H, AU - Pfeiffer,E F, PY - 1992/10/1/pubmed PY - 1992/10/1/medline PY - 1992/10/1/entrez SP - 492 EP - 3 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm Metab Res VL - 24 IS - 10 N2 - The microdialysis technique was used for following the glucose content of the extracellular subcutaneous (SC) fluid under varying blood glucose levels in rats. The glucose content in the microdialysis perfusion fluid was continuously analyzed by means of the measuring flow chamber of an ex vivo glucose monitor. In six ChBB rats blood glucose levels were varied between 40 mg/dl and 575 mg/dl by intravenous (IV) infusion of glucose and by SC injections of insulin, respectively. After a running-in period of about half an hour, the glucose content in the perfusion fluid was closely related to the blood glucose concentration (r > 0.92) up to a time period of 6 hrs. The "relative recovery" rate of glucose by the microdialysis probe in the SC tissue varied within the 6 experimental sessions. The relative recovery rate could be shown to be not dependent on the absolute blood glucose levels in the individual rat within the glucose concentration range tested. SN - 0018-5043 UR - https://www.unboundmedicine.com/medline/citation/1464417/Combination_of_microdialysis_and_glucosensor_permits_continuous__on_line__SC_glucose_monitoring_in_a_patient_operated_device__II__Evaluation_in_animals_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-1003370 DB - PRIME DP - Unbound Medicine ER -