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Does caffeine and alcohol intake before pregnancy predict the occurrence of spontaneous abortion?
Hum Reprod. 2003 Dec; 18(12):2704-10.HR

Abstract

BACKGROUND

Consumption of caffeine and alcohol is suspected to affect pregnancy outcome. Use of both stimulants is widespread and even minor effects on fetal viability are of public health interest.

METHODS

We performed a nested case-control study using prospective data from a population-based cohort comprising 11088 women aged 20-29 years. From this cohort, women who experienced either a spontaneous abortion (n = 303) or who gave birth (n = 1381) during follow-up [mean time: 2.1 years (range: 1.6-3.4)] were selected. Associations between self-reported exposures to caffeine and/or alcohol at enrolment and spontaneous abortion were analysed by means of logistic regression.

RESULTS

Compared with women with a pre-pregnancy intake of <75 mg caffeine per day, the adjusted odds ratio (95% confidence interval) for spontaneous abortion was 1.26 (0.77-2.06), 1.45 (0.87-2.41), 1.44 (0.87-2.37) and 1.72 (1.00-2.96) for a pre-pregnancy intake on 75-300, 301-500, 501-900 and >900 mg caffeine per day respectively (P = 0.05 for trend). A pre-pregnancy intake of alcohol was not a predictor for spontaneous abortion.

CONCLUSIONS

A high intake of caffeine prior to pregnancy seems to be associated with an increased risk of spontaneous abortion, whereas a low-to-moderate alcohol intake does not influence the risk.

Authors+Show Affiliations

Danish Epidemiology Science Centre at the Institute of Preventive Medicine, Kommunehospitalet, DK-1399, Copenhagen, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14645195

Citation

Tolstrup, J S., et al. "Does Caffeine and Alcohol Intake Before Pregnancy Predict the Occurrence of Spontaneous Abortion?" Human Reproduction (Oxford, England), vol. 18, no. 12, 2003, pp. 2704-10.
Tolstrup JS, Kjaer SK, Munk C, et al. Does caffeine and alcohol intake before pregnancy predict the occurrence of spontaneous abortion? Hum Reprod. 2003;18(12):2704-10.
Tolstrup, J. S., Kjaer, S. K., Munk, C., Madsen, L. B., Ottesen, B., Bergholt, T., & Grønbaek, M. (2003). Does caffeine and alcohol intake before pregnancy predict the occurrence of spontaneous abortion? Human Reproduction (Oxford, England), 18(12), 2704-10.
Tolstrup JS, et al. Does Caffeine and Alcohol Intake Before Pregnancy Predict the Occurrence of Spontaneous Abortion. Hum Reprod. 2003;18(12):2704-10. PubMed PMID: 14645195.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does caffeine and alcohol intake before pregnancy predict the occurrence of spontaneous abortion? AU - Tolstrup,J S, AU - Kjaer,S K, AU - Munk,C, AU - Madsen,L B, AU - Ottesen,B, AU - Bergholt,T, AU - Grønbaek,M, PY - 2003/12/3/pubmed PY - 2004/7/24/medline PY - 2003/12/3/entrez SP - 2704 EP - 10 JF - Human reproduction (Oxford, England) JO - Hum. Reprod. VL - 18 IS - 12 N2 - BACKGROUND: Consumption of caffeine and alcohol is suspected to affect pregnancy outcome. Use of both stimulants is widespread and even minor effects on fetal viability are of public health interest. METHODS: We performed a nested case-control study using prospective data from a population-based cohort comprising 11088 women aged 20-29 years. From this cohort, women who experienced either a spontaneous abortion (n = 303) or who gave birth (n = 1381) during follow-up [mean time: 2.1 years (range: 1.6-3.4)] were selected. Associations between self-reported exposures to caffeine and/or alcohol at enrolment and spontaneous abortion were analysed by means of logistic regression. RESULTS: Compared with women with a pre-pregnancy intake of <75 mg caffeine per day, the adjusted odds ratio (95% confidence interval) for spontaneous abortion was 1.26 (0.77-2.06), 1.45 (0.87-2.41), 1.44 (0.87-2.37) and 1.72 (1.00-2.96) for a pre-pregnancy intake on 75-300, 301-500, 501-900 and >900 mg caffeine per day respectively (P = 0.05 for trend). A pre-pregnancy intake of alcohol was not a predictor for spontaneous abortion. CONCLUSIONS: A high intake of caffeine prior to pregnancy seems to be associated with an increased risk of spontaneous abortion, whereas a low-to-moderate alcohol intake does not influence the risk. SN - 0268-1161 UR - https://www.unboundmedicine.com/medline/citation/14645195/Does_caffeine_and_alcohol_intake_before_pregnancy_predict_the_occurrence_of_spontaneous_abortion L2 - https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/deg480 DB - PRIME DP - Unbound Medicine ER -