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Use of contemporary biomarkers in the detection of chronic alcohol use.
Med Sci Monit. 2003 Dec; 9(12):RA285-90.MS

Abstract

Alcohol is the most commonly abused substance yet alcoholism is frequently undiagnosed. The misuse of alcohol is common and frequently an occult problem. More than 10% of current drinkers meet diagnostic criteria for alcohol abuse or dependence while the lifetime prevalence for these conditions in outpatient settings ranges from 16 to 36 percent. Long-term, heavy drinking is associated with significant morbidity, mortality, and economic costs. Clues to alcohol use can be discovered from a patient's history and physical stigmata. Validated screening instruments such as the Alcohol Use Disorders Identification Test (AUDIT), CAGE Questionnaire, and Brief Michigan Alcoholism Screening Tests help confirm the clinical suspicion of alcohol dependence. Laboratory abnormalities of mean corpuscular volume, gamma-glutamyl transferase, alkaline phosphatase, or alanine amino transferase levels are non-specific indicators of possible alcohol-induced liver impairment. Newer, less well-known FDA-approved biochemical markers such as the Carbohydrate Deficient Transferrin and the Early Detection of Alcohol Consumption test may also be used to detect heavy alcohol abuse and to monitor relapse episodes. Brief interventions are successful, making identification and diagnosis a vital role for the family physician. Improved awareness of alcohol misuse, increased use of screening tools, and the appropriate use of biochemical markers will facilitate early intervention and successful management of patients with alcohol use disorders.

Authors+Show Affiliations

Department of Family Medicine, West Virginia University School of Medicine, Charleston, WV, U.S.A.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Review

Language

eng

PubMed ID

14646983

Citation

Montalto, Norman J., and Pamela Bean. "Use of Contemporary Biomarkers in the Detection of Chronic Alcohol Use." Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, vol. 9, no. 12, 2003, pp. RA285-90.
Montalto NJ, Bean P. Use of contemporary biomarkers in the detection of chronic alcohol use. Med Sci Monit. 2003;9(12):RA285-90.
Montalto, N. J., & Bean, P. (2003). Use of contemporary biomarkers in the detection of chronic alcohol use. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 9(12), RA285-90.
Montalto NJ, Bean P. Use of Contemporary Biomarkers in the Detection of Chronic Alcohol Use. Med Sci Monit. 2003;9(12):RA285-90. PubMed PMID: 14646983.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of contemporary biomarkers in the detection of chronic alcohol use. AU - Montalto,Norman J, AU - Bean,Pamela, PY - 2003/12/4/pubmed PY - 2004/2/24/medline PY - 2003/12/4/entrez SP - RA285 EP - 90 JF - Medical science monitor : international medical journal of experimental and clinical research JO - Med. Sci. Monit. VL - 9 IS - 12 N2 - Alcohol is the most commonly abused substance yet alcoholism is frequently undiagnosed. The misuse of alcohol is common and frequently an occult problem. More than 10% of current drinkers meet diagnostic criteria for alcohol abuse or dependence while the lifetime prevalence for these conditions in outpatient settings ranges from 16 to 36 percent. Long-term, heavy drinking is associated with significant morbidity, mortality, and economic costs. Clues to alcohol use can be discovered from a patient's history and physical stigmata. Validated screening instruments such as the Alcohol Use Disorders Identification Test (AUDIT), CAGE Questionnaire, and Brief Michigan Alcoholism Screening Tests help confirm the clinical suspicion of alcohol dependence. Laboratory abnormalities of mean corpuscular volume, gamma-glutamyl transferase, alkaline phosphatase, or alanine amino transferase levels are non-specific indicators of possible alcohol-induced liver impairment. Newer, less well-known FDA-approved biochemical markers such as the Carbohydrate Deficient Transferrin and the Early Detection of Alcohol Consumption test may also be used to detect heavy alcohol abuse and to monitor relapse episodes. Brief interventions are successful, making identification and diagnosis a vital role for the family physician. Improved awareness of alcohol misuse, increased use of screening tools, and the appropriate use of biochemical markers will facilitate early intervention and successful management of patients with alcohol use disorders. SN - 1234-1010 UR - https://www.unboundmedicine.com/medline/citation/14646983/Use_of_contemporary_biomarkers_in_the_detection_of_chronic_alcohol_use_ L2 - https://www.medscimonit.com/download/index/idArt/13445 DB - PRIME DP - Unbound Medicine ER -