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[Musculoskeletal manifestations as the onset of acute leukemias in childhood].
J Pediatr (Rio J). 2002 Nov-Dec; 78(6):481-4.JP

Abstract

OBJECTIVE

To study the frequency, the clinical features and laboratory exams of patients with musculoskeletal symptoms at the onset of acute leukemia.

METHODS

Retrospective, descriptive study including patients diagnosed with acute leukemia, and treated at the Institute of Pediatric Oncology of UNIFESP, carried out from November 1999 to February 2000. The data on musculoskeletal complaints were obtained from a questionnaire. The medical records were revised in order to get data on the clinical examination and laboratory tests at the beginning of the illness.

RESULTS

Sixty-one children were included in this trial, 93% with acute lymphoid leukemia, and 7% with acute myeloid leukemia. Thirty-eight patients (62%) had musculoskeletal pain at the onset. Arthritis was observed in eight patients. The mean number of involved joints was 2.5 (1-6). The most frequently involved joints were the knees, ankles and elbows. Three patients (4.9%) had normal blood count. Low hemoglobin was reported in 54 patients (88%) (in six patients it was the only hematological abnormality), leukopenia in 14 (22%), leukocytosis in 26 (42%) and low platelet count in 46 (75%).

CONCLUSIONS

The musculoskeletal symptoms are common at the onset of acute leukemia so, malignancy should always be ruled out in patients presenting chronic or acute arthritis or benign limb pain. The laboratory tests may be normal at the onset of the illness, making differential diagnosis more difficult.

Authors+Show Affiliations

Dep de Pediatria, Universidade Federal de São Paulo, SP. cassia@vicnet.com.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

por

PubMed ID

14647728

Citation

Barbosa, Cássia Maria Passarelli Lupoli, et al. "[Musculoskeletal Manifestations as the Onset of Acute Leukemias in Childhood]." Jornal De Pediatria, vol. 78, no. 6, 2002, pp. 481-4.
Barbosa CM, Nakamura C, Terreri MT, et al. [Musculoskeletal manifestations as the onset of acute leukemias in childhood]. J Pediatr (Rio J). 2002;78(6):481-4.
Barbosa, C. M., Nakamura, C., Terreri, M. T., Lee, M. L., Petrilli, A. S., & Hilário, M. O. (2002). [Musculoskeletal manifestations as the onset of acute leukemias in childhood]. Jornal De Pediatria, 78(6), 481-4.
Barbosa CM, et al. [Musculoskeletal Manifestations as the Onset of Acute Leukemias in Childhood]. J Pediatr (Rio J). 2002 Nov-Dec;78(6):481-4. PubMed PMID: 14647728.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Musculoskeletal manifestations as the onset of acute leukemias in childhood]. AU - Barbosa,Cássia Maria Passarelli Lupoli, AU - Nakamura,Cláudia, AU - Terreri,Maria Teresa, AU - Lee,Maria Lúcia de Martino, AU - Petrilli,Antonio Sergio, AU - Hilário,Maria Odete Esteves, PY - 2003/12/4/pubmed PY - 2003/12/4/medline PY - 2003/12/4/entrez SP - 481 EP - 4 JF - Jornal de pediatria JO - J Pediatr (Rio J) VL - 78 IS - 6 N2 - OBJECTIVE: To study the frequency, the clinical features and laboratory exams of patients with musculoskeletal symptoms at the onset of acute leukemia. METHODS: Retrospective, descriptive study including patients diagnosed with acute leukemia, and treated at the Institute of Pediatric Oncology of UNIFESP, carried out from November 1999 to February 2000. The data on musculoskeletal complaints were obtained from a questionnaire. The medical records were revised in order to get data on the clinical examination and laboratory tests at the beginning of the illness. RESULTS: Sixty-one children were included in this trial, 93% with acute lymphoid leukemia, and 7% with acute myeloid leukemia. Thirty-eight patients (62%) had musculoskeletal pain at the onset. Arthritis was observed in eight patients. The mean number of involved joints was 2.5 (1-6). The most frequently involved joints were the knees, ankles and elbows. Three patients (4.9%) had normal blood count. Low hemoglobin was reported in 54 patients (88%) (in six patients it was the only hematological abnormality), leukopenia in 14 (22%), leukocytosis in 26 (42%) and low platelet count in 46 (75%). CONCLUSIONS: The musculoskeletal symptoms are common at the onset of acute leukemia so, malignancy should always be ruled out in patients presenting chronic or acute arthritis or benign limb pain. The laboratory tests may be normal at the onset of the illness, making differential diagnosis more difficult. SN - 0021-7557 UR - https://www.unboundmedicine.com/medline/citation/14647728/[Musculoskeletal_manifestations_as_the_onset_of_acute_leukemias_in_childhood]_ L2 - http://www.jped.com.br/conteudo/02-78-06-481/ing.asp DB - PRIME DP - Unbound Medicine ER -
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