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Kinetics of change in the eotaxin concentration in serum and cerebrospinal fluid of mice infected with Angiostrongylus cantonensis.
Parasitol Res. 2004 Jan; 92(2):137-41.PR

Abstract

The kinetics of changes in the eotaxin concentration in the serum and cerebrospinal fluid (CSF) of BALB/c mice after infection with Angiostrongylus cantonensis and the correlation between the concentration of eotaxin and worm recovery were investigated. The mean concentration of eotaxin in serum of infected mice gradually increased from 46.3+/-6.5 pg/ml at week 0 to 104.9+/-44.8 pg/ml at week 3 after infection, while the mean eotaxin level in the CSF of infected mice rapidly increased from 18.7+/-2.1 pg/ml to 193.2+/-23.6 pg/ml 1 week after infection and then increased further to 507.8+/-167.9 pg/ml at week 3. The concentrations of eotaxin in the CSF of infected mice each week after infection were all significantly higher than those in serum (P<0.0001). In parallel with the increase in eotaxin in the CSF, infected mice showed gradual increases in CSF eosinophilia and a reduction in intracranial worm recovery. The concentration of eotaxin in CSF was higher in infected mice with more worms in the brain, except when the number of worms in the brain was >30. In addition, when the worm counts in the brains of infected mice were <30, eotaxin concentrations in the CSF were positively correlated with worm counts in the brain (P<0.001). Thus, the release of eotaxin in the CSF of mice infected with A. cantonensis observed in this study was time dependent and worm-load dependent, and in parallel with the increase in eotaxin in the CSF, and gradual decreases in worm counts in the brains of infected mice.

Authors+Show Affiliations

Department of Parasitology, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung City, Taiwan, Taiwan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14648203

Citation

Chang, Eddy Essen, et al. "Kinetics of Change in the Eotaxin Concentration in Serum and Cerebrospinal Fluid of Mice Infected With Angiostrongylus Cantonensis." Parasitology Research, vol. 92, no. 2, 2004, pp. 137-41.
Chang EE, Chung LY, Yen CM. Kinetics of change in the eotaxin concentration in serum and cerebrospinal fluid of mice infected with Angiostrongylus cantonensis. Parasitol Res. 2004;92(2):137-41.
Chang, E. E., Chung, L. Y., & Yen, C. M. (2004). Kinetics of change in the eotaxin concentration in serum and cerebrospinal fluid of mice infected with Angiostrongylus cantonensis. Parasitology Research, 92(2), 137-41.
Chang EE, Chung LY, Yen CM. Kinetics of Change in the Eotaxin Concentration in Serum and Cerebrospinal Fluid of Mice Infected With Angiostrongylus Cantonensis. Parasitol Res. 2004;92(2):137-41. PubMed PMID: 14648203.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Kinetics of change in the eotaxin concentration in serum and cerebrospinal fluid of mice infected with Angiostrongylus cantonensis. AU - Chang,Eddy Essen, AU - Chung,Lee-Yi, AU - Yen,Chuan-Min, Y1 - 2003/11/27/ PY - 2003/07/20/received PY - 2003/09/11/accepted PY - 2003/12/3/pubmed PY - 2004/4/15/medline PY - 2003/12/3/entrez SP - 137 EP - 41 JF - Parasitology research JO - Parasitol Res VL - 92 IS - 2 N2 - The kinetics of changes in the eotaxin concentration in the serum and cerebrospinal fluid (CSF) of BALB/c mice after infection with Angiostrongylus cantonensis and the correlation between the concentration of eotaxin and worm recovery were investigated. The mean concentration of eotaxin in serum of infected mice gradually increased from 46.3+/-6.5 pg/ml at week 0 to 104.9+/-44.8 pg/ml at week 3 after infection, while the mean eotaxin level in the CSF of infected mice rapidly increased from 18.7+/-2.1 pg/ml to 193.2+/-23.6 pg/ml 1 week after infection and then increased further to 507.8+/-167.9 pg/ml at week 3. The concentrations of eotaxin in the CSF of infected mice each week after infection were all significantly higher than those in serum (P<0.0001). In parallel with the increase in eotaxin in the CSF, infected mice showed gradual increases in CSF eosinophilia and a reduction in intracranial worm recovery. The concentration of eotaxin in CSF was higher in infected mice with more worms in the brain, except when the number of worms in the brain was >30. In addition, when the worm counts in the brains of infected mice were <30, eotaxin concentrations in the CSF were positively correlated with worm counts in the brain (P<0.001). Thus, the release of eotaxin in the CSF of mice infected with A. cantonensis observed in this study was time dependent and worm-load dependent, and in parallel with the increase in eotaxin in the CSF, and gradual decreases in worm counts in the brains of infected mice. SN - 0932-0113 UR - https://www.unboundmedicine.com/medline/citation/14648203/Kinetics_of_change_in_the_eotaxin_concentration_in_serum_and_cerebrospinal_fluid_of_mice_infected_with_Angiostrongylus_cantonensis_ L2 - https://dx.doi.org/10.1007/s00436-003-1017-0 DB - PRIME DP - Unbound Medicine ER -