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In vitro antiviral activity of prodelphinidin B-2 3,3'-di-O-gallate from Myrica rubra.
Planta Med. 2003 Oct; 69(10):953-6.PM

Abstract

In this study, the in vitro antiviral properties of prodelphinidin B-2 3,3'-di- O-gallate (PB233'OG) isolated from the bark of Myrica rubra (Myricaceae) was investigated. Results showed that PB233'OG exhibited anti-herpes simplex virus type 2 (HSV-2) activity with IC (50) values of 5.3 +/- 0.1 and 0.4 +/- 0.04 microM for XTT and plaque reduction assays, respectively. The IC (50) value increased with increasing MOI (multiplicity of infection). PB233'OG did not show a cellular cytotoxic effect at concentrations that possessed antiviral activity. Mechanistic studies demonstrated that PB233'OG inhibited HSV-2 attachment to the Vero cell, interfered with the penetration of HSV-2 into the Vero cell, affected the late stage(s) of the HSV-2 infection cycle, and also reduced the viral infectivity at high concentrations. It is concluded that PB233'OG exhibits various modes of action in its anti-HSV-2 effects.

Authors+Show Affiliations

Cheng HY
Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.
Lin TC
No affiliation info available
Ishimaru K
No affiliation info available
Yang CM
No affiliation info available
Wang KC
No affiliation info available
Lin CC
No affiliation info available

MeSH

AnimalsAnthocyaninsAntiviral AgentsChlorocebus aethiopsHerpesvirus 2, HumanInhibitory Concentration 50MyricaPhytotherapyPlant BarkPlant ExtractsVero Cells

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14648402

Citation

Cheng, Hua-Yew, et al. "In Vitro Antiviral Activity of Prodelphinidin B-2 3,3'-di-O-gallate From Myrica Rubra." Planta Medica, vol. 69, no. 10, 2003, pp. 953-6.
Cheng HY, Lin TC, Ishimaru K, et al. In vitro antiviral activity of prodelphinidin B-2 3,3'-di-O-gallate from Myrica rubra. Planta Med. 2003;69(10):953-6.
Cheng, H. Y., Lin, T. C., Ishimaru, K., Yang, C. M., Wang, K. C., & Lin, C. C. (2003). In vitro antiviral activity of prodelphinidin B-2 3,3'-di-O-gallate from Myrica rubra. Planta Medica, 69(10), 953-6.
Cheng HY, et al. In Vitro Antiviral Activity of Prodelphinidin B-2 3,3'-di-O-gallate From Myrica Rubra. Planta Med. 2003;69(10):953-6. PubMed PMID: 14648402.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro antiviral activity of prodelphinidin B-2 3,3'-di-O-gallate from Myrica rubra. AU - Cheng,Hua-Yew, AU - Lin,Ta-Chen, AU - Ishimaru,Kanji, AU - Yang,Chien-Min, AU - Wang,Kuo-Chih, AU - Lin,Chun-Ching, PY - 2003/12/4/pubmed PY - 2004/2/10/medline PY - 2003/12/4/entrez SP - 953 EP - 6 JF - Planta medica JO - Planta Med VL - 69 IS - 10 N2 - In this study, the in vitro antiviral properties of prodelphinidin B-2 3,3'-di- O-gallate (PB233'OG) isolated from the bark of Myrica rubra (Myricaceae) was investigated. Results showed that PB233'OG exhibited anti-herpes simplex virus type 2 (HSV-2) activity with IC (50) values of 5.3 +/- 0.1 and 0.4 +/- 0.04 microM for XTT and plaque reduction assays, respectively. The IC (50) value increased with increasing MOI (multiplicity of infection). PB233'OG did not show a cellular cytotoxic effect at concentrations that possessed antiviral activity. Mechanistic studies demonstrated that PB233'OG inhibited HSV-2 attachment to the Vero cell, interfered with the penetration of HSV-2 into the Vero cell, affected the late stage(s) of the HSV-2 infection cycle, and also reduced the viral infectivity at high concentrations. It is concluded that PB233'OG exhibits various modes of action in its anti-HSV-2 effects. SN - 0032-0943 UR - https://www.unboundmedicine.com/medline/citation/14648402/In_vitro_antiviral_activity_of_prodelphinidin_B_2_33'_di_O_gallate_from_Myrica_rubra_ DB - PRIME DP - Unbound Medicine ER -