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Tissue inhibitor of metalloproteinase (TIMP)-1: the TIMPed balance of matrix metalloproteinases in the central nervous system.
J Neurosci Res. 2003 Dec 15; 74(6):801-6.JN

Abstract

Astrocytes are intimately involved in the mechanisms of neural injury and repair. They participate in a variety of homeostatic functions and elicit repair responses as balance mechanisms. Currently, there is a growing appreciation of a more active role of astrocytes in neuronal signaling and function. One key homeostatic mechanism of astrocytes in tissue repair is maintained through their production of tissue inhibitors of metalloproteinases (TIMPs). The family of TIMPs (1-4) plays a central regulatory role as inhibitors of matrix metalloproteinases (MMPs), enzymes involved in extracellular matrix maintenance and remodeling. Recently, TIMP-1, the inducible form, has been identified as a multifunctional molecule with divergent functions. It participates in wound healing and regeneration, cell morphology and survival, tumor metastasis, angiogenesis, and inflammatory responses. An imbalance of MMP/TIMP regulation has been implicated in several inflammatory diseases of the central nervous system (CNS). Here we review the conundrums of TIMP-1 regulation in CNS pathophysiology. We propose that astrocyte-TIMP-1 may play an important role in CNS homeostasis and disease. Astrocyte TIMP-1 expression is differentially regulated in inflammatory neurodegenerative diseases and may have significant therapeutic relevance.

Authors+Show Affiliations

Laboratory of Cellular Neuroimmunology, Center for Neurovirology and Neurodegenerative Disorders, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-5215, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

14648584

Citation

Gardner, Jessica, and Anuja Ghorpade. "Tissue Inhibitor of Metalloproteinase (TIMP)-1: the TIMPed Balance of Matrix Metalloproteinases in the Central Nervous System." Journal of Neuroscience Research, vol. 74, no. 6, 2003, pp. 801-6.
Gardner J, Ghorpade A. Tissue inhibitor of metalloproteinase (TIMP)-1: the TIMPed balance of matrix metalloproteinases in the central nervous system. J Neurosci Res. 2003;74(6):801-6.
Gardner, J., & Ghorpade, A. (2003). Tissue inhibitor of metalloproteinase (TIMP)-1: the TIMPed balance of matrix metalloproteinases in the central nervous system. Journal of Neuroscience Research, 74(6), 801-6.
Gardner J, Ghorpade A. Tissue Inhibitor of Metalloproteinase (TIMP)-1: the TIMPed Balance of Matrix Metalloproteinases in the Central Nervous System. J Neurosci Res. 2003 Dec 15;74(6):801-6. PubMed PMID: 14648584.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tissue inhibitor of metalloproteinase (TIMP)-1: the TIMPed balance of matrix metalloproteinases in the central nervous system. AU - Gardner,Jessica, AU - Ghorpade,Anuja, PY - 2003/12/4/pubmed PY - 2004/1/31/medline PY - 2003/12/4/entrez SP - 801 EP - 6 JF - Journal of neuroscience research JO - J Neurosci Res VL - 74 IS - 6 N2 - Astrocytes are intimately involved in the mechanisms of neural injury and repair. They participate in a variety of homeostatic functions and elicit repair responses as balance mechanisms. Currently, there is a growing appreciation of a more active role of astrocytes in neuronal signaling and function. One key homeostatic mechanism of astrocytes in tissue repair is maintained through their production of tissue inhibitors of metalloproteinases (TIMPs). The family of TIMPs (1-4) plays a central regulatory role as inhibitors of matrix metalloproteinases (MMPs), enzymes involved in extracellular matrix maintenance and remodeling. Recently, TIMP-1, the inducible form, has been identified as a multifunctional molecule with divergent functions. It participates in wound healing and regeneration, cell morphology and survival, tumor metastasis, angiogenesis, and inflammatory responses. An imbalance of MMP/TIMP regulation has been implicated in several inflammatory diseases of the central nervous system (CNS). Here we review the conundrums of TIMP-1 regulation in CNS pathophysiology. We propose that astrocyte-TIMP-1 may play an important role in CNS homeostasis and disease. Astrocyte TIMP-1 expression is differentially regulated in inflammatory neurodegenerative diseases and may have significant therapeutic relevance. SN - 0360-4012 UR - https://www.unboundmedicine.com/medline/citation/14648584/Tissue_inhibitor_of_metalloproteinase__TIMP__1:_the_TIMPed_balance_of_matrix_metalloproteinases_in_the_central_nervous_system_ L2 - https://doi.org/10.1002/jnr.10835 DB - PRIME DP - Unbound Medicine ER -