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[Dynamics of T lymphocyte subsets in SARS patients].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2003 Oct; 25(5):525-8.ZY

Abstract

OBJECTIVE

To study dynamics of T lymphocyte subsets in severe acute respiratory syndrome (SARS).

METHODS

Sequential anti-coagulated blood samples were collected from 46 cases of SARS patients during the 1st week, the 2nd week, the 3rd-5th week and the 8th-12th week after the infection. T lymphocyte subsets including CD3+CD4+ cells, CD3+CD8+ cells, naive CD4+ cells (CD4+CD45RA+CD62L+) and activated CD8+ cells (CD8+CD38+) were detected by 3-color flow cytometry. Fifty-six normal healthy blood donors were also detected as normal controls.

RESULTS

Compared with the results of normal controls, both of the percentages of CD4+ cells and CD8+ cells of SARS patients were in normal levels during the 1st week, but the cell counts decreased significantly to (306 +/- 140)/mm3 and (270 +/- 143)/mm3, respectively. The cell count of naive CD4+ subset also remarkably decreased to (96 +/- 49)/mm3, and the percentage of CD8+CD38+ subset was higher than that of normal controls [(59.3 +/- 12.6)% vs (44.9 +/- 12.5)%]. During the 3rd-5th week, the CD8+ cell count and the percentage of CD8+CD38+ subset reached normal values, which were (581 +/- 356)/mm3 and (40.1 +/- 17.6)%, respectively. During the 8th-12th week, the cell counts of CD4+ cell [(578 +/- 193)/mm3] and naive CD4+ subset [(176 +/- 64)/mm3] were still less than those of normal controls, while compared with those of the 1st week, the increments were remarkable.

CONCLUSIONS

T lymphocytes of SARS patients decreased dramatically but could be obviously resumed in a short time. It will take more than 8-12 weeks for CD4+ cell and naive CD4+ subset to reach to normal levels.

Authors+Show Affiliations

Department of Infectious Disease, PUMC Hospital, CAMS and PUMC, Beijing 100730, China. qiu_Zhifeng@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

14650150

Citation

Qiu, Zhi-feng, et al. "[Dynamics of T Lymphocyte Subsets in SARS Patients]." Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae, vol. 25, no. 5, 2003, pp. 525-8.
Qiu ZF, Li TS, Fan HW, et al. [Dynamics of T lymphocyte subsets in SARS patients]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2003;25(5):525-8.
Qiu, Z. F., Li, T. S., Fan, H. W., Han, Y., Xie, J., Wang, A. X., & Deng, G. H. (2003). [Dynamics of T lymphocyte subsets in SARS patients]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae, 25(5), 525-8.
Qiu ZF, et al. [Dynamics of T Lymphocyte Subsets in SARS Patients]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2003;25(5):525-8. PubMed PMID: 14650150.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Dynamics of T lymphocyte subsets in SARS patients]. AU - Qiu,Zhi-feng, AU - Li,Tai-sheng, AU - Fan,Hong-wei, AU - Han,Yang, AU - Xie,Jing, AU - Wang,Ai-xia, AU - Deng,Guo-hua, PY - 2003/12/3/pubmed PY - 2004/6/26/medline PY - 2003/12/3/entrez SP - 525 EP - 8 JF - Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae JO - Zhongguo Yi Xue Ke Xue Yuan Xue Bao VL - 25 IS - 5 N2 - OBJECTIVE: To study dynamics of T lymphocyte subsets in severe acute respiratory syndrome (SARS). METHODS: Sequential anti-coagulated blood samples were collected from 46 cases of SARS patients during the 1st week, the 2nd week, the 3rd-5th week and the 8th-12th week after the infection. T lymphocyte subsets including CD3+CD4+ cells, CD3+CD8+ cells, naive CD4+ cells (CD4+CD45RA+CD62L+) and activated CD8+ cells (CD8+CD38+) were detected by 3-color flow cytometry. Fifty-six normal healthy blood donors were also detected as normal controls. RESULTS: Compared with the results of normal controls, both of the percentages of CD4+ cells and CD8+ cells of SARS patients were in normal levels during the 1st week, but the cell counts decreased significantly to (306 +/- 140)/mm3 and (270 +/- 143)/mm3, respectively. The cell count of naive CD4+ subset also remarkably decreased to (96 +/- 49)/mm3, and the percentage of CD8+CD38+ subset was higher than that of normal controls [(59.3 +/- 12.6)% vs (44.9 +/- 12.5)%]. During the 3rd-5th week, the CD8+ cell count and the percentage of CD8+CD38+ subset reached normal values, which were (581 +/- 356)/mm3 and (40.1 +/- 17.6)%, respectively. During the 8th-12th week, the cell counts of CD4+ cell [(578 +/- 193)/mm3] and naive CD4+ subset [(176 +/- 64)/mm3] were still less than those of normal controls, while compared with those of the 1st week, the increments were remarkable. CONCLUSIONS: T lymphocytes of SARS patients decreased dramatically but could be obviously resumed in a short time. It will take more than 8-12 weeks for CD4+ cell and naive CD4+ subset to reach to normal levels. SN - 1000-503X UR - https://www.unboundmedicine.com/medline/citation/14650150/[Dynamics_of_T_lymphocyte_subsets_in_SARS_patients]_ L2 - https://www.diseaseinfosearch.org/result/6415 DB - PRIME DP - Unbound Medicine ER -