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Adolescent diet and incidence of proliferative benign breast disease.

Abstract

Studies of adult diet and risk of breast cancer have yielded mainly null results, but this does not rule out a possible impact of adolescent diet. This study examined associations between components of adolescent diet and risk of proliferative benign breast disease (BBD), a marker for breast cancer. The study population consisted of 29494 women in the Nurses' Health Study II who completed a questionnaire on adolescent diet in 1998 and who were 33-53 years of age at that time. A total of 470 new cases of proliferative BBD were identified between 1991 and 1997. Incidence rate ratios (RRs) and 95% confidence intervals (CIs) were calculated for quartiles of energy-adjusted intakes, using the lowest quartile of each as the reference group. Total fat intake during adolescence was unrelated to risk of proliferative BBD, although there were positive associations for intakes of animal fat and monounsaturated fat and an inverse association for intake of vegetable fat. For vitamin E intake, the multivariate RRs were 1.13, 0.88, and 0.79 (95% CI, 0.61-1.04) for women in the second, third, and highest quartiles, respectively (P for trend = 0.05). The multivariate RRs were 0.94, 0.99, and 0.75 (95% CI, 0.57-0.98) for women in increasing quartiles of fiber intake (P for trend = 0.05). Vegetable fat, vitamin E, and fiber intakes during adolescence were inversely associated with risk of proliferative BBD in this population. Confirmation of these associations may suggest a means for prevention of breast cancer.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. hbaer@hsph.harvard.edu

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    Source

    MeSH

    Adolescent
    Adolescent Behavior
    Adult
    Breast Diseases
    Breast Neoplasms
    Cohort Studies
    Diet
    Dietary Fats
    Dietary Fiber
    Female
    Humans
    Middle Aged
    Odds Ratio
    Risk Factors
    Vegetables

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, Non-P.H.S.
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    14652275

    Citation

    Baer, Heather J., et al. "Adolescent Diet and Incidence of Proliferative Benign Breast Disease." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 12, no. 11 Pt 1, 2003, pp. 1159-67.
    Baer HJ, Schnitt SJ, Connolly JL, et al. Adolescent diet and incidence of proliferative benign breast disease. Cancer Epidemiol Biomarkers Prev. 2003;12(11 Pt 1):1159-67.
    Baer, H. J., Schnitt, S. J., Connolly, J. L., Byrne, C., Cho, E., Willett, W. C., & Colditz, G. A. (2003). Adolescent diet and incidence of proliferative benign breast disease. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 12(11 Pt 1), pp. 1159-67.
    Baer HJ, et al. Adolescent Diet and Incidence of Proliferative Benign Breast Disease. Cancer Epidemiol Biomarkers Prev. 2003;12(11 Pt 1):1159-67. PubMed PMID: 14652275.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Adolescent diet and incidence of proliferative benign breast disease. AU - Baer,Heather J, AU - Schnitt,Stuart J, AU - Connolly,James L, AU - Byrne,Celia, AU - Cho,Eunyoung, AU - Willett,Walter C, AU - Colditz,Graham A, PY - 2003/12/4/pubmed PY - 2004/3/17/medline PY - 2003/12/4/entrez SP - 1159 EP - 67 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 12 IS - 11 Pt 1 N2 - Studies of adult diet and risk of breast cancer have yielded mainly null results, but this does not rule out a possible impact of adolescent diet. This study examined associations between components of adolescent diet and risk of proliferative benign breast disease (BBD), a marker for breast cancer. The study population consisted of 29494 women in the Nurses' Health Study II who completed a questionnaire on adolescent diet in 1998 and who were 33-53 years of age at that time. A total of 470 new cases of proliferative BBD were identified between 1991 and 1997. Incidence rate ratios (RRs) and 95% confidence intervals (CIs) were calculated for quartiles of energy-adjusted intakes, using the lowest quartile of each as the reference group. Total fat intake during adolescence was unrelated to risk of proliferative BBD, although there were positive associations for intakes of animal fat and monounsaturated fat and an inverse association for intake of vegetable fat. For vitamin E intake, the multivariate RRs were 1.13, 0.88, and 0.79 (95% CI, 0.61-1.04) for women in the second, third, and highest quartiles, respectively (P for trend = 0.05). The multivariate RRs were 0.94, 0.99, and 0.75 (95% CI, 0.57-0.98) for women in increasing quartiles of fiber intake (P for trend = 0.05). Vegetable fat, vitamin E, and fiber intakes during adolescence were inversely associated with risk of proliferative BBD in this population. Confirmation of these associations may suggest a means for prevention of breast cancer. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/14652275/Adolescent_diet_and_incidence_of_proliferative_benign_breast_disease_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=14652275 DB - PRIME DP - Unbound Medicine ER -