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[Expression of vascular endothelial growth factor in the peritoneal fluid and eutopic endometrium of patients with endometriosis].
Hunan Yi Ke Da Xue Xue Bao. 2003 Jun; 28(3):288-90.HY

Abstract

OBJECTIVE

To investigate the significance of vascular endothelial growth factor (VEGF) on the etiology of endometriosis.

METHODS

The level of VEGF in the peritoneal fluid from women with endometriosis (n = 19) and non-endometriosis (n = 21) was studied by ELISA. The expression of VEGF of eutopic endometrium collected from women with endometriosis (n = 15) and non-endometriosis (n = 12) was determined by relative quantity RT-PCR.

RESULTS

The level of VEGF in the peritoneal fluid in the endometriosis was higher than that of the controls (P < 0.05). Cyclic variation in VEGF concentration was seen in the peritoneal fluid from patients with endometriosis, and the VEGF concentration in the proliferative phase was significantly higher than that in the secretory phase (P < 0.05). No cyclic variation in VEGF was seen in the control group (P > 0.05). The expression of VEGF in the eutopic endometrium with endometriosis was significantly higher than that of the controls (P < 0.001). There was no significant difference between the proliferative and secretory phase in endometriosis (P > 0.05).

CONCLUSION

The increase of VEGF in the peritoneal fluid and eutopic endometrium with endometriosis may be important to the occurrence and development of endometriosis.

Authors+Show Affiliations

Department of Gynecology and Obstetrics, Second Xiangya Hospital, Central South University, Changsha 410011, China.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

14653093

Citation

Fang, Xiao-ling, et al. "[Expression of Vascular Endothelial Growth Factor in the Peritoneal Fluid and Eutopic Endometrium of Patients With Endometriosis]." Hunan Yi Ke Da Xue Xue Bao = Hunan Yike Daxue Xuebao = Bulletin of Hunan Medical University, vol. 28, no. 3, 2003, pp. 288-90.
Fang XL, Xia XM, Lin QH. [Expression of vascular endothelial growth factor in the peritoneal fluid and eutopic endometrium of patients with endometriosis]. Hunan Yi Ke Da Xue Xue Bao. 2003;28(3):288-90.
Fang, X. L., Xia, X. M., & Lin, Q. H. (2003). [Expression of vascular endothelial growth factor in the peritoneal fluid and eutopic endometrium of patients with endometriosis]. Hunan Yi Ke Da Xue Xue Bao = Hunan Yike Daxue Xuebao = Bulletin of Hunan Medical University, 28(3), 288-90.
Fang XL, Xia XM, Lin QH. [Expression of Vascular Endothelial Growth Factor in the Peritoneal Fluid and Eutopic Endometrium of Patients With Endometriosis]. Hunan Yi Ke Da Xue Xue Bao. 2003;28(3):288-90. PubMed PMID: 14653093.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Expression of vascular endothelial growth factor in the peritoneal fluid and eutopic endometrium of patients with endometriosis]. AU - Fang,Xiao-ling, AU - Xia,Xiao-meng, AU - Lin,Qiu-hua, PY - 2003/12/5/pubmed PY - 2004/5/15/medline PY - 2003/12/5/entrez SP - 288 EP - 90 JF - Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University JO - Hunan Yi Ke Da Xue Xue Bao VL - 28 IS - 3 N2 - OBJECTIVE: To investigate the significance of vascular endothelial growth factor (VEGF) on the etiology of endometriosis. METHODS: The level of VEGF in the peritoneal fluid from women with endometriosis (n = 19) and non-endometriosis (n = 21) was studied by ELISA. The expression of VEGF of eutopic endometrium collected from women with endometriosis (n = 15) and non-endometriosis (n = 12) was determined by relative quantity RT-PCR. RESULTS: The level of VEGF in the peritoneal fluid in the endometriosis was higher than that of the controls (P < 0.05). Cyclic variation in VEGF concentration was seen in the peritoneal fluid from patients with endometriosis, and the VEGF concentration in the proliferative phase was significantly higher than that in the secretory phase (P < 0.05). No cyclic variation in VEGF was seen in the control group (P > 0.05). The expression of VEGF in the eutopic endometrium with endometriosis was significantly higher than that of the controls (P < 0.001). There was no significant difference between the proliferative and secretory phase in endometriosis (P > 0.05). CONCLUSION: The increase of VEGF in the peritoneal fluid and eutopic endometrium with endometriosis may be important to the occurrence and development of endometriosis. SN - 1000-5625 UR - https://www.unboundmedicine.com/medline/citation/14653093/[Expression_of_vascular_endothelial_growth_factor_in_the_peritoneal_fluid_and_eutopic_endometrium_of_patients_with_endometriosis]_ L2 - http://www.diseaseinfosearch.org/result/2537 DB - PRIME DP - Unbound Medicine ER -
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