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Possible role of antibody specific for a practolol metabolite in the pathogenesis of oculomucocutaneous syndrome.

Abstract

The clinical distribution of an antibody to a metabolite of practolol was investigated, particularly in relation to the oculomucocutaneous syndrome. Serum samples were obtained from patients with and without a history of adverse reaction to practolol and two groups of control patients who had never taken the drug. Five patients also participated in a challenge study. The presence of the antibody was found to be related to practolol administration, and antibody activity could be increased by antigenic challenge. The role of this antibody in the pathogenesis of the oculomucocutaneous syndrome remains uncertain. The lesions may be the result of a hitherto unknown type of hypersensitivity response to practolol.

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  • Authors

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    Source

    British medical journal 1:6110 1978 Feb 18 pg 402-4

    MeSH

    Antibodies
    Antibody Specificity
    Drug Eruptions
    Eye Diseases
    Humans
    Mucous Membrane
    Practolol
    Syndrome

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    146533

    Citation

    Amos, H E., et al. "Possible Role of Antibody Specific for a Practolol Metabolite in the Pathogenesis of Oculomucocutaneous Syndrome." British Medical Journal, vol. 1, no. 6110, 1978, pp. 402-4.
    Amos HE, Lake BG, Artis J. Possible role of antibody specific for a practolol metabolite in the pathogenesis of oculomucocutaneous syndrome. Br Med J. 1978;1(6110):402-4.
    Amos, H. E., Lake, B. G., & Artis, J. (1978). Possible role of antibody specific for a practolol metabolite in the pathogenesis of oculomucocutaneous syndrome. British Medical Journal, 1(6110), pp. 402-4.
    Amos HE, Lake BG, Artis J. Possible Role of Antibody Specific for a Practolol Metabolite in the Pathogenesis of Oculomucocutaneous Syndrome. Br Med J. 1978 Feb 18;1(6110):402-4. PubMed PMID: 146533.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Possible role of antibody specific for a practolol metabolite in the pathogenesis of oculomucocutaneous syndrome. AU - Amos,H E, AU - Lake,B G, AU - Artis,J, PY - 1978/2/18/pubmed PY - 1978/2/18/medline PY - 1978/2/18/entrez SP - 402 EP - 4 JF - British medical journal JO - Br Med J VL - 1 IS - 6110 N2 - The clinical distribution of an antibody to a metabolite of practolol was investigated, particularly in relation to the oculomucocutaneous syndrome. Serum samples were obtained from patients with and without a history of adverse reaction to practolol and two groups of control patients who had never taken the drug. Five patients also participated in a challenge study. The presence of the antibody was found to be related to practolol administration, and antibody activity could be increased by antigenic challenge. The role of this antibody in the pathogenesis of the oculomucocutaneous syndrome remains uncertain. The lesions may be the result of a hitherto unknown type of hypersensitivity response to practolol. SN - 0007-1447 UR - https://www.unboundmedicine.com/medline/citation/146533/Possible_role_of_antibody_specific_for_a_practolol_metabolite_in_the_pathogenesis_of_oculomucocutaneous_syndrome_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/146533/ DB - PRIME DP - Unbound Medicine ER -