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The alternative sigma factor katF (rpoS) regulates Salmonella virulence.
Proc Natl Acad Sci U S A. 1992 Dec 15; 89(24):11978-82.PN

Abstract

Nutrient limitation is a critical signal in Salmonella virulence gene regulation. The katF (rpoS) gene mediates the expression of the Salmonella spv plasmid virulence genes during bacterial starvation. A katF Salmonella mutant has increased susceptibility to nutrient deprivation, oxidative stress, acid stress, and DNA damage, conditions which are relevant to the intraphagosomal environment of host macrophages. Moreover, the katF mutant has significantly reduced virulence in mice. katF encodes an alternative sigma factor of RNA polymerase which coordinately regulates Salmonella virulence.

Authors+Show Affiliations

Department of Medicine, University of California, San Diego 92103.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1465428

Citation

Fang, F C., et al. "The Alternative Sigma Factor katF (rpoS) Regulates Salmonella Virulence." Proceedings of the National Academy of Sciences of the United States of America, vol. 89, no. 24, 1992, pp. 11978-82.
Fang FC, Libby SJ, Buchmeier NA, et al. The alternative sigma factor katF (rpoS) regulates Salmonella virulence. Proc Natl Acad Sci U S A. 1992;89(24):11978-82.
Fang, F. C., Libby, S. J., Buchmeier, N. A., Loewen, P. C., Switala, J., Harwood, J., & Guiney, D. G. (1992). The alternative sigma factor katF (rpoS) regulates Salmonella virulence. Proceedings of the National Academy of Sciences of the United States of America, 89(24), 11978-82.
Fang FC, et al. The Alternative Sigma Factor katF (rpoS) Regulates Salmonella Virulence. Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):11978-82. PubMed PMID: 1465428.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The alternative sigma factor katF (rpoS) regulates Salmonella virulence. AU - Fang,F C, AU - Libby,S J, AU - Buchmeier,N A, AU - Loewen,P C, AU - Switala,J, AU - Harwood,J, AU - Guiney,D G, PY - 1992/12/15/pubmed PY - 1992/12/15/medline PY - 1992/12/15/entrez SP - 11978 EP - 82 JF - Proceedings of the National Academy of Sciences of the United States of America JO - Proc Natl Acad Sci U S A VL - 89 IS - 24 N2 - Nutrient limitation is a critical signal in Salmonella virulence gene regulation. The katF (rpoS) gene mediates the expression of the Salmonella spv plasmid virulence genes during bacterial starvation. A katF Salmonella mutant has increased susceptibility to nutrient deprivation, oxidative stress, acid stress, and DNA damage, conditions which are relevant to the intraphagosomal environment of host macrophages. Moreover, the katF mutant has significantly reduced virulence in mice. katF encodes an alternative sigma factor of RNA polymerase which coordinately regulates Salmonella virulence. SN - 0027-8424 UR - https://www.unboundmedicine.com/medline/citation/1465428/The_alternative_sigma_factor_katF__rpoS__regulates_Salmonella_virulence_ L2 - http://www.pnas.org/cgi/pmidlookup?view=long&pmid=1465428 DB - PRIME DP - Unbound Medicine ER -