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Prophylactic iv ondansetron reduces nausea, vomiting and pruritus following epidural morphine for postoperative pain control.
Can J Anaesth. 2003 Dec; 50(10):1023-6.CJ

Abstract

PURPOSE

To evaluate the prophylactic effect of ondansetron on nausea and vomiting following epidural morphine for postoperative pain control.

METHODS

Seventy women (n = 35 in each group) undergoing abdominal total hysterectomy under epidural anesthesia were enrolled in this randomized, double-blinded, and placebo-controlled study. At the end of surgery, all patients received epidural morphine 3 mg for postoperative pain relief. Before morphine injection, the ondansetron group received iv ondansetron 4 mg, whereas the placebo group received iv saline.

RESULTS

Patients in the ondansetron group reported a lower frequency of total postoperative nausea and vomiting (22%) and lower frequency of rescue antiemetic request (12%) than those in the placebo group (52% and 39%, respectively; P < 0.05). In addition, ondansetron was associated with a reduced incidence of pruritus following epidural morphine (28% vs 58%; P < 0.05).

CONCLUSION

We conclude that iv ondansetron 4 mg is effective in the prevention of nausea, vomiting, and pruritus following epidural morphine for postoperative pain control.

Authors+Show Affiliations

Departments of Medical Research and Anesthesiology, Chi-Mei Medical Center, Tainan, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

14656780

Citation

Tzeng, Jann-Inn, et al. "Prophylactic Iv Ondansetron Reduces Nausea, Vomiting and Pruritus Following Epidural Morphine for Postoperative Pain Control." Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie, vol. 50, no. 10, 2003, pp. 1023-6.
Tzeng JI, Chu KS, Ho ST, et al. Prophylactic iv ondansetron reduces nausea, vomiting and pruritus following epidural morphine for postoperative pain control. Can J Anaesth. 2003;50(10):1023-6.
Tzeng, J. I., Chu, K. S., Ho, S. T., Cheng, K. I., Liu, K. S., & Wang, J. J. (2003). Prophylactic iv ondansetron reduces nausea, vomiting and pruritus following epidural morphine for postoperative pain control. Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie, 50(10), 1023-6.
Tzeng JI, et al. Prophylactic Iv Ondansetron Reduces Nausea, Vomiting and Pruritus Following Epidural Morphine for Postoperative Pain Control. Can J Anaesth. 2003;50(10):1023-6. PubMed PMID: 14656780.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prophylactic iv ondansetron reduces nausea, vomiting and pruritus following epidural morphine for postoperative pain control. AU - Tzeng,Jann-Inn, AU - Chu,Koung-Shing, AU - Ho,Shung-Tai, AU - Cheng,Kuang-I, AU - Liu,Kuo-Sheng, AU - Wang,Jhi-Joung, PY - 2003/12/6/pubmed PY - 2004/5/20/medline PY - 2003/12/6/entrez SP - 1023 EP - 6 JF - Canadian journal of anaesthesia = Journal canadien d'anesthesie JO - Can J Anaesth VL - 50 IS - 10 N2 - PURPOSE: To evaluate the prophylactic effect of ondansetron on nausea and vomiting following epidural morphine for postoperative pain control. METHODS: Seventy women (n = 35 in each group) undergoing abdominal total hysterectomy under epidural anesthesia were enrolled in this randomized, double-blinded, and placebo-controlled study. At the end of surgery, all patients received epidural morphine 3 mg for postoperative pain relief. Before morphine injection, the ondansetron group received iv ondansetron 4 mg, whereas the placebo group received iv saline. RESULTS: Patients in the ondansetron group reported a lower frequency of total postoperative nausea and vomiting (22%) and lower frequency of rescue antiemetic request (12%) than those in the placebo group (52% and 39%, respectively; P < 0.05). In addition, ondansetron was associated with a reduced incidence of pruritus following epidural morphine (28% vs 58%; P < 0.05). CONCLUSION: We conclude that iv ondansetron 4 mg is effective in the prevention of nausea, vomiting, and pruritus following epidural morphine for postoperative pain control. SN - 0832-610X UR - https://www.unboundmedicine.com/medline/citation/14656780/Prophylactic_iv_ondansetron_reduces_nausea_vomiting_and_pruritus_following_epidural_morphine_for_postoperative_pain_control_ L2 - https://doi.org/10.1007/BF03018366 DB - PRIME DP - Unbound Medicine ER -