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Comparison of racemic albuterol and levalbuterol for treatment of acute asthma.
J Pediatr 2003; 143(6):731-6JPed

Abstract

OBJECTIVE

To determine whether levalbuterol resulted in fewer hospital admissions than racemic albuterol when used for treatment of acute asthma. Study design A randomized, double-blind, controlled trial was conducted in the emergency department (ED) and inpatient asthma care unit of an urban tertiary children's hospital. Children age 1 to 18 years (n=482) provided a total of 547 enrollments. Patients received a nebulized solution of either 2.5 mg racemic albuterol or 1.25 mg levalbuterol every 20 minutes (maximum six doses). Patients admitted to the asthma care unit were treated in a standardized fashion by using the same blinded drug assigned in the ED. Hospitalization rate was the primary outcome.

RESULTS

Hospitalization rate was significantly lower in the levalbuterol group (36%) than in the racemic albuterol group (45 %, P=.02). The adjusted relative risk of admission in the racemic group compared with the levalbuterol group was 1.25 (95% confidence interval, 1.01-1.57). Hospital length of stay was not significantly shorter in the levalbuterol group (levalbuterol, 44.9 hours; racemic albuterol, 50.3 hours; P=.63). No significant adverse events occurred in either group.

CONCLUSIONS

Substituting levalbuterol for racemic albuterol in the ED management of acute asthma significantly reduced the number of hospitalizations.

Authors+Show Affiliations

Department of Pediatrics, Case Western Reserve University, University Hospitals of Cleveland, Rainbow Babies and Children's Hospital, Cleveland, Ohio 44106, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14657817

Citation

Carl, John C., et al. "Comparison of Racemic Albuterol and Levalbuterol for Treatment of Acute Asthma." The Journal of Pediatrics, vol. 143, no. 6, 2003, pp. 731-6.
Carl JC, Myers TR, Kirchner HL, et al. Comparison of racemic albuterol and levalbuterol for treatment of acute asthma. J Pediatr. 2003;143(6):731-6.
Carl, J. C., Myers, T. R., Kirchner, H. L., & Kercsmar, C. M. (2003). Comparison of racemic albuterol and levalbuterol for treatment of acute asthma. The Journal of Pediatrics, 143(6), pp. 731-6.
Carl JC, et al. Comparison of Racemic Albuterol and Levalbuterol for Treatment of Acute Asthma. J Pediatr. 2003;143(6):731-6. PubMed PMID: 14657817.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of racemic albuterol and levalbuterol for treatment of acute asthma. AU - Carl,John C, AU - Myers,Timothy R, AU - Kirchner,H Lester, AU - Kercsmar,Carolyn M, PY - 2003/12/6/pubmed PY - 2004/1/9/medline PY - 2003/12/6/entrez SP - 731 EP - 6 JF - The Journal of pediatrics JO - J. Pediatr. VL - 143 IS - 6 N2 - OBJECTIVE: To determine whether levalbuterol resulted in fewer hospital admissions than racemic albuterol when used for treatment of acute asthma. Study design A randomized, double-blind, controlled trial was conducted in the emergency department (ED) and inpatient asthma care unit of an urban tertiary children's hospital. Children age 1 to 18 years (n=482) provided a total of 547 enrollments. Patients received a nebulized solution of either 2.5 mg racemic albuterol or 1.25 mg levalbuterol every 20 minutes (maximum six doses). Patients admitted to the asthma care unit were treated in a standardized fashion by using the same blinded drug assigned in the ED. Hospitalization rate was the primary outcome. RESULTS: Hospitalization rate was significantly lower in the levalbuterol group (36%) than in the racemic albuterol group (45 %, P=.02). The adjusted relative risk of admission in the racemic group compared with the levalbuterol group was 1.25 (95% confidence interval, 1.01-1.57). Hospital length of stay was not significantly shorter in the levalbuterol group (levalbuterol, 44.9 hours; racemic albuterol, 50.3 hours; P=.63). No significant adverse events occurred in either group. CONCLUSIONS: Substituting levalbuterol for racemic albuterol in the ED management of acute asthma significantly reduced the number of hospitalizations. SN - 0022-3476 UR - https://www.unboundmedicine.com/medline/citation/14657817/Comparison_of_racemic_albuterol_and_levalbuterol_for_treatment_of_acute_asthma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3476(03)00493-1 DB - PRIME DP - Unbound Medicine ER -