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Prenatal exposure to polychlorinated biphenyls and attention at school age.
J Pediatr. 2003 Dec; 143(6):780-8.JPed

Abstract

OBJECTIVE

To examine the relation of prenatal polychlorinated biphenyl (PCB) exposure to child performance on neuropsychological tests of attention and information processing. Study design In this prospective, longitudinal study, assessment of prenatal PCB exposure was based on umbilical cord serum and maternal serum and milk concentrations. The children were tested in their homes at age 11 years. Multiple regression was used to examine the relation of this exposure to performance on 15 neuropsychological tests after controlling for a broad range of potential confounding variables.

RESULTS

Adverse effects were seen primarily in children who had not been breast fed. Among these children, prenatal PCB exposure was associated with greater impulsivity, poorer concentration, and poorer verbal, pictorial, and auditory working memory. There was no evidence of visual-spatial deficit or increased hyperactivity.

CONCLUSIONS

These findings are consistent with earlier reports of greater vulnerability to prenatal PCB exposure in children who were not breast fed. It is not clear whether the protection offered by breast-feeding is caused by nutrients in breast milk or better quality of intellectual stimulation often provided by breast-feeding mothers.

Authors+Show Affiliations

Department of Psychology, Wayne State University, Detroit, Michigan 48202, USA. joseph.jacobso@wayne.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

14657828

Citation

Jacobson, Joseph L., and Sandra W. Jacobson. "Prenatal Exposure to Polychlorinated Biphenyls and Attention at School Age." The Journal of Pediatrics, vol. 143, no. 6, 2003, pp. 780-8.
Jacobson JL, Jacobson SW. Prenatal exposure to polychlorinated biphenyls and attention at school age. J Pediatr. 2003;143(6):780-8.
Jacobson, J. L., & Jacobson, S. W. (2003). Prenatal exposure to polychlorinated biphenyls and attention at school age. The Journal of Pediatrics, 143(6), 780-8.
Jacobson JL, Jacobson SW. Prenatal Exposure to Polychlorinated Biphenyls and Attention at School Age. J Pediatr. 2003;143(6):780-8. PubMed PMID: 14657828.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal exposure to polychlorinated biphenyls and attention at school age. AU - Jacobson,Joseph L, AU - Jacobson,Sandra W, PY - 2003/12/6/pubmed PY - 2004/1/9/medline PY - 2003/12/6/entrez SP - 780 EP - 8 JF - The Journal of pediatrics JO - J Pediatr VL - 143 IS - 6 N2 - OBJECTIVE: To examine the relation of prenatal polychlorinated biphenyl (PCB) exposure to child performance on neuropsychological tests of attention and information processing. Study design In this prospective, longitudinal study, assessment of prenatal PCB exposure was based on umbilical cord serum and maternal serum and milk concentrations. The children were tested in their homes at age 11 years. Multiple regression was used to examine the relation of this exposure to performance on 15 neuropsychological tests after controlling for a broad range of potential confounding variables. RESULTS: Adverse effects were seen primarily in children who had not been breast fed. Among these children, prenatal PCB exposure was associated with greater impulsivity, poorer concentration, and poorer verbal, pictorial, and auditory working memory. There was no evidence of visual-spatial deficit or increased hyperactivity. CONCLUSIONS: These findings are consistent with earlier reports of greater vulnerability to prenatal PCB exposure in children who were not breast fed. It is not clear whether the protection offered by breast-feeding is caused by nutrients in breast milk or better quality of intellectual stimulation often provided by breast-feeding mothers. SN - 0022-3476 UR - https://www.unboundmedicine.com/medline/citation/14657828/Prenatal_exposure_to_polychlorinated_biphenyls_and_attention_at_school_age_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3476(03)00577-8 DB - PRIME DP - Unbound Medicine ER -