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Systems mediating acute glucocorticoid effects on memory consolidation and retrieval.
Prog Neuropsychopharmacol Biol Psychiatry. 2003 Dec; 27(8):1213-23.PN

Abstract

It is well established that glucocorticoid hormones, secreted by the adrenal cortex after a stressful event, influence cognitive performance. This article reviews recent findings from this laboratory on the acute effects of glucocorticoids in rats on specific memory phases, i.e., memory consolidation and memory retrieval. Posttraining activation of glucocorticoid-sensitive pathways involving glucocorticoid receptors (GRs) enhances memory consolidation in a dose-dependent manner. Glucocorticoid influences on memory consolidation depend on noradrenergic activation of the basolateral complex of the amygdala (BLA) and interactions of the BLA with other brain regions. By contrast, memory retrieval processes are usually impaired with high circulating levels of glucocorticoids or following infusions of GR agonists into the hippocampus. Although the BLA does not appear to be a site of glucocorticoid action in influencing memory retrieval, an intact BLA is required for enabling glucocorticoid effects on memory retrieval. The BLA appears to be a key structure in a memory-modulatory system that regulates, in concert with other brain regions, stress and glucocorticoid effects on both memory consolidation and memory retrieval.

Authors+Show Affiliations

Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697-3800, USA. broozend@uci.edu

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

14659476

Citation

Roozendaal, Benno. "Systems Mediating Acute Glucocorticoid Effects On Memory Consolidation and Retrieval." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 27, no. 8, 2003, pp. 1213-23.
Roozendaal B. Systems mediating acute glucocorticoid effects on memory consolidation and retrieval. Prog Neuropsychopharmacol Biol Psychiatry. 2003;27(8):1213-23.
Roozendaal, B. (2003). Systems mediating acute glucocorticoid effects on memory consolidation and retrieval. Progress in Neuro-psychopharmacology & Biological Psychiatry, 27(8), 1213-23.
Roozendaal B. Systems Mediating Acute Glucocorticoid Effects On Memory Consolidation and Retrieval. Prog Neuropsychopharmacol Biol Psychiatry. 2003;27(8):1213-23. PubMed PMID: 14659476.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Systems mediating acute glucocorticoid effects on memory consolidation and retrieval. A1 - Roozendaal,Benno, PY - 2003/12/9/pubmed PY - 2004/2/28/medline PY - 2003/12/9/entrez SP - 1213 EP - 23 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog Neuropsychopharmacol Biol Psychiatry VL - 27 IS - 8 N2 - It is well established that glucocorticoid hormones, secreted by the adrenal cortex after a stressful event, influence cognitive performance. This article reviews recent findings from this laboratory on the acute effects of glucocorticoids in rats on specific memory phases, i.e., memory consolidation and memory retrieval. Posttraining activation of glucocorticoid-sensitive pathways involving glucocorticoid receptors (GRs) enhances memory consolidation in a dose-dependent manner. Glucocorticoid influences on memory consolidation depend on noradrenergic activation of the basolateral complex of the amygdala (BLA) and interactions of the BLA with other brain regions. By contrast, memory retrieval processes are usually impaired with high circulating levels of glucocorticoids or following infusions of GR agonists into the hippocampus. Although the BLA does not appear to be a site of glucocorticoid action in influencing memory retrieval, an intact BLA is required for enabling glucocorticoid effects on memory retrieval. The BLA appears to be a key structure in a memory-modulatory system that regulates, in concert with other brain regions, stress and glucocorticoid effects on both memory consolidation and memory retrieval. SN - 0278-5846 UR - https://www.unboundmedicine.com/medline/citation/14659476/Systems_mediating_acute_glucocorticoid_effects_on_memory_consolidation_and_retrieval_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(03)00228-8 DB - PRIME DP - Unbound Medicine ER -