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Antipanic-like effect of serotonin reuptake inhibitors in the elevated T-maze.
Behav Brain Res. 2003 Dec 17; 147(1-2):185-92.BB

Abstract

There has been an increasing interest in the development of animal models that address different types of anxiety disorders. The elevated T-maze (ETM) was developed based on the assumption that inhibitory avoidance and one-way escape are respectively related to generalized anxiety (GAD) and panic disorder (PD). Although anxiolytic effects on the inhibitory avoidance task have been shown for drugs used in clinical settings to treat GAD, positive effects of antipanic drugs in one-way escape have been described only for imipramine. The study extends the pharmacological validation of the ETM to other serotonin reuptake inhibitors that have antipanic properties. To this end, we investigated the effects of acute and chronic (21 days) IP administration of clomipramine (3, 10 and 30 mg/kg) and fluoxetine (5, 10 and 15 mg/kg). Buspirone (0.3, 1 and 3 mg/kg) was used as a negative control since the drug is effective in GAD but not PD. Chronically, both clomipramine and fluoxetine impaired one-escape, an antipanic-like effect, not altering avoidance latencies. Clomipramine, but not fluoxetine, also affected locomotion. Acute injection of buspirone impaired avoidance, an anxiolytic-like effect. Neither acute nor chronic buspirone altered one-escape. These results corroborate the suggestion that one-way escape is related to PD.

Authors+Show Affiliations

Poltronieri SC
Laboratory of Psychobiology, FFCLRP, University of São Paulo, 14040-901 Ribeirão Preto, Brazil.
Zangrossi H
No affiliation info available
de Barros Viana M
No affiliation info available

MeSH

Analysis of VarianceAnimalsDisease Models, AnimalEscape ReactionMaleMaze LearningMotor ActivityPanic DisorderRatsRats, WistarReaction TimeSelective Serotonin Reuptake InhibitorsTimeTime Factors

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14659584

Citation

Poltronieri, Selma Conceição, et al. "Antipanic-like Effect of Serotonin Reuptake Inhibitors in the Elevated T-maze." Behavioural Brain Research, vol. 147, no. 1-2, 2003, pp. 185-92.
Poltronieri SC, Zangrossi H, de Barros Viana M. Antipanic-like effect of serotonin reuptake inhibitors in the elevated T-maze. Behav Brain Res. 2003;147(1-2):185-92.
Poltronieri, S. C., Zangrossi, H., & de Barros Viana, M. (2003). Antipanic-like effect of serotonin reuptake inhibitors in the elevated T-maze. Behavioural Brain Research, 147(1-2), 185-92.
Poltronieri SC, Zangrossi H, de Barros Viana M. Antipanic-like Effect of Serotonin Reuptake Inhibitors in the Elevated T-maze. Behav Brain Res. 2003 Dec 17;147(1-2):185-92. PubMed PMID: 14659584.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antipanic-like effect of serotonin reuptake inhibitors in the elevated T-maze. AU - Poltronieri,Selma Conceição, AU - Zangrossi,Hélio,Jr AU - de Barros Viana,Milena, PY - 2003/12/9/pubmed PY - 2004/2/24/medline PY - 2003/12/9/entrez SP - 185 EP - 92 JF - Behavioural brain research JO - Behav Brain Res VL - 147 IS - 1-2 N2 - There has been an increasing interest in the development of animal models that address different types of anxiety disorders. The elevated T-maze (ETM) was developed based on the assumption that inhibitory avoidance and one-way escape are respectively related to generalized anxiety (GAD) and panic disorder (PD). Although anxiolytic effects on the inhibitory avoidance task have been shown for drugs used in clinical settings to treat GAD, positive effects of antipanic drugs in one-way escape have been described only for imipramine. The study extends the pharmacological validation of the ETM to other serotonin reuptake inhibitors that have antipanic properties. To this end, we investigated the effects of acute and chronic (21 days) IP administration of clomipramine (3, 10 and 30 mg/kg) and fluoxetine (5, 10 and 15 mg/kg). Buspirone (0.3, 1 and 3 mg/kg) was used as a negative control since the drug is effective in GAD but not PD. Chronically, both clomipramine and fluoxetine impaired one-escape, an antipanic-like effect, not altering avoidance latencies. Clomipramine, but not fluoxetine, also affected locomotion. Acute injection of buspirone impaired avoidance, an anxiolytic-like effect. Neither acute nor chronic buspirone altered one-escape. These results corroborate the suggestion that one-way escape is related to PD. SN - 0166-4328 UR - https://www.unboundmedicine.com/medline/citation/14659584/Antipanic_like_effect_of_serotonin_reuptake_inhibitors_in_the_elevated_T_maze_ DB - PRIME DP - Unbound Medicine ER -