TY - JOUR T1 - Successful treatment of dandruff with 1.5% ciclopirox olamine shampoo in Korea. AU - Lee,J H, AU - Lee,H S, AU - Eun,H C, AU - Cho,K H, PY - 2003/12/9/pubmed PY - 2004/1/16/medline PY - 2003/12/9/entrez SP - 212 EP - 5 JF - The Journal of dermatological treatment JO - J Dermatolog Treat VL - 14 IS - 4 N2 - BACKGROUND: Dandruff is a chronic scalp condition characterized by scaling. The common causative agent is now accepted to be the lipophilic yeast Malassezia furfur. Ketoconazole, a highly effective antifungal agent against M. furfur has been used for the treatment of dandruff. AIM: To determine whether a 1.5% ciclopirox olamine shampoo is as effective as a 2% ketoconazole shampoo for the treatment of mild to moderate dandruff. METHODS: A total of 64 patients, with mild to moderate dandruff, participated in the study. The study consisted of three consecutive phases: a 2-week washout period, a 4-week treatment period and a 2-week post-treatment period. Patients were randomized equally to either the 1.5% ciclopirox olamine shampoo or 2% ketoconazole shampoo. An overall dandruff score was calculated using an area of dandruff involvement score and a severity score. Patients evaluated the presence of pruritus and also reported a global evaluation of efficacy. RESULTS: In all, 57 patients successfully completed all three phases. The overall dandruff score declined progressively throughout the treatment period for both shampoos. A slight increase in pruritus was observed in the ciclopirox olamine treatment group during the post-treatment phase. Regarding global self-assessment of efficacy, both treatment groups were pleased with their scalp condition following treatment. CONCLUSION: Ciclopirox olamine shampoo appears to offer an effective, safe and easy to use treatment for mild to moderate dandruff. SN - 0954-6634 UR - https://www.unboundmedicine.com/medline/citation/14660265/Successful_treatment_of_dandruff_with_1_5_ciclopirox_olamine_shampoo_in_Korea_ DB - PRIME DP - Unbound Medicine ER -