Tags

Type your tag names separated by a space and hit enter

[Osteoporosis in inflammatory bowel disease - results of a survey among members of the German Crohn's and Ulcerative Colitis Association].
Z Gastroenterol. 2003 Dec; 41(12):1145-50.ZG

Abstract

INTRODUCTION

Osteoporosis is a frequent and clinically important complication in inflammatory bowel disease (IBD). Prevalence and risk factors have been examined in small numbers of patients. With a nationwide survey of members of the German Crohn's and Ulcerative Colitis Association (DCCV) we wanted to evaluate the situation in a larger group of patients.

METHODS

Questionnaires were sent with the autumn issue of the members journal to approx. 14,620 affected members of the DCCV. Items covered osteoporosis, clinical symptoms, anamnesis and sociodemographic topics. Results are presented as descriptive analysis and in a logistic regression analysis of factors contributing to the osteoporosis risk.

RESULTS

2,536 questionnaires could be used (17.3 %). Mean age and distribution concerning diagnosis and gender were comparable to the DCCV members in total. The prevalence of pathologic bone density was 62.3 % in those 1,265 patients (50.1 %) who underwent bone densitometry in the course of their disease. The analysis led to the following possible risk factors: disease activity (high chronic activity or more than 1 acute flare annually vs. remission, p < 0.001), lifetime steroid dosage > 10 g (p = 0.002), Crohn's disease vs. ulcerative colitis (p = 0.02), multiple bowel resection (p = 0.032), age (p = 0.018) and low body mass index (p = 0.034). 83.4 % of the patients with pathologic bone density received specific therapy, but most of those (63.5 %) were solely substituted with calcium and vitamin D.

CONCLUSION

This is the first study looking at epidemiology and risk factors of osteoporosis in a large study population of patients with inflammatory bowel disease. Although the prevalence may be overestimated due to selection bias in our study, osteoporosis is confirmed as a frequent and clinically relevant complication in IBD. Bone densitometry is recommended in those patients with one or more risk factors.

Authors+Show Affiliations

Abteilung Innere Medizin I, Universitätsklinikum Ulm. christian.tripitz@medizin.uni-ulm.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

ger

PubMed ID

14661123

Citation

von Tirpitz, C, et al. "[Osteoporosis in Inflammatory Bowel Disease - Results of a Survey Among Members of the German Crohn's and Ulcerative Colitis Association]." Zeitschrift Fur Gastroenterologie, vol. 41, no. 12, 2003, pp. 1145-50.
von Tirpitz C, Steder-Neukamm U, Glas K, et al. [Osteoporosis in inflammatory bowel disease - results of a survey among members of the German Crohn's and Ulcerative Colitis Association]. Z Gastroenterol. 2003;41(12):1145-50.
von Tirpitz, C., Steder-Neukamm, U., Glas, K., Sander, S., Ring, C., Klaus, J., & Reinshagen, M. (2003). [Osteoporosis in inflammatory bowel disease - results of a survey among members of the German Crohn's and Ulcerative Colitis Association]. Zeitschrift Fur Gastroenterologie, 41(12), 1145-50.
von Tirpitz C, et al. [Osteoporosis in Inflammatory Bowel Disease - Results of a Survey Among Members of the German Crohn's and Ulcerative Colitis Association]. Z Gastroenterol. 2003;41(12):1145-50. PubMed PMID: 14661123.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Osteoporosis in inflammatory bowel disease - results of a survey among members of the German Crohn's and Ulcerative Colitis Association]. AU - von Tirpitz,C, AU - Steder-Neukamm,U, AU - Glas,K, AU - Sander,S, AU - Ring,C, AU - Klaus,J, AU - Reinshagen,M, PY - 2003/12/9/pubmed PY - 2004/3/5/medline PY - 2003/12/9/entrez SP - 1145 EP - 50 JF - Zeitschrift fur Gastroenterologie JO - Z Gastroenterol VL - 41 IS - 12 N2 - INTRODUCTION: Osteoporosis is a frequent and clinically important complication in inflammatory bowel disease (IBD). Prevalence and risk factors have been examined in small numbers of patients. With a nationwide survey of members of the German Crohn's and Ulcerative Colitis Association (DCCV) we wanted to evaluate the situation in a larger group of patients. METHODS: Questionnaires were sent with the autumn issue of the members journal to approx. 14,620 affected members of the DCCV. Items covered osteoporosis, clinical symptoms, anamnesis and sociodemographic topics. Results are presented as descriptive analysis and in a logistic regression analysis of factors contributing to the osteoporosis risk. RESULTS: 2,536 questionnaires could be used (17.3 %). Mean age and distribution concerning diagnosis and gender were comparable to the DCCV members in total. The prevalence of pathologic bone density was 62.3 % in those 1,265 patients (50.1 %) who underwent bone densitometry in the course of their disease. The analysis led to the following possible risk factors: disease activity (high chronic activity or more than 1 acute flare annually vs. remission, p < 0.001), lifetime steroid dosage > 10 g (p = 0.002), Crohn's disease vs. ulcerative colitis (p = 0.02), multiple bowel resection (p = 0.032), age (p = 0.018) and low body mass index (p = 0.034). 83.4 % of the patients with pathologic bone density received specific therapy, but most of those (63.5 %) were solely substituted with calcium and vitamin D. CONCLUSION: This is the first study looking at epidemiology and risk factors of osteoporosis in a large study population of patients with inflammatory bowel disease. Although the prevalence may be overestimated due to selection bias in our study, osteoporosis is confirmed as a frequent and clinically relevant complication in IBD. Bone densitometry is recommended in those patients with one or more risk factors. SN - 0044-2771 UR - https://www.unboundmedicine.com/medline/citation/14661123/[Osteoporosis_in_inflammatory_bowel_disease___results_of_a_survey_among_members_of_the_German_Crohn's_and_Ulcerative_Colitis_Association]_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2003-45280 DB - PRIME DP - Unbound Medicine ER -