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Analytical separations in open-tubular capillary electrochromatography.
Electrophoresis. 2003 Dec; 24(22-23):3917-34.E

Abstract

This review represents a summary of recent progress in open-tubular capillary electrochromatography (OT-CEC) for chiral and achiral separations. The OT-CEC approach is an alternative to packed-CEC that could eliminate the problems associated with retaining frits and silica particles. In OT-CEC, the stationary phase is immobilized on the inner walls of the capillary. Preparation of the stationary phase is critical for OT-CEC. The preparation methods for capillary columns include (i) adsorption, (ii) covalent bonding and/or cross-linking, (iii) porous layers, (iv) chemical bonding after etching, (v) sol-gel, and (vi) molecular imprinting. Major developments, potential applications, technical difficulties and advantages associated with these wall coatings in OT-CEC are presented. In addition, the coupling of OT-CEC with mass spectrometry (MS) is briefly reviewed. Several applications of this hyphenated technique for analytical separations are also summarized.

Authors+Show Affiliations

Kapnissi-Christodoulou CP
Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA.
Zhu X
No affiliation info available
Warner IM
No affiliation info available

MeSH

CelluloseChromatographyElectrophoresis, CapillaryMass SpectrometryPolymers

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

14661227

Citation

Kapnissi-Christodoulou, Constantina P., et al. "Analytical Separations in Open-tubular Capillary Electrochromatography." Electrophoresis, vol. 24, no. 22-23, 2003, pp. 3917-34.
Kapnissi-Christodoulou CP, Zhu X, Warner IM. Analytical separations in open-tubular capillary electrochromatography. Electrophoresis. 2003;24(22-23):3917-34.
Kapnissi-Christodoulou, C. P., Zhu, X., & Warner, I. M. (2003). Analytical separations in open-tubular capillary electrochromatography. Electrophoresis, 24(22-23), 3917-34.
Kapnissi-Christodoulou CP, Zhu X, Warner IM. Analytical Separations in Open-tubular Capillary Electrochromatography. Electrophoresis. 2003;24(22-23):3917-34. PubMed PMID: 14661227.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analytical separations in open-tubular capillary electrochromatography. AU - Kapnissi-Christodoulou,Constantina P, AU - Zhu,Xiaofeng, AU - Warner,Isiah M, PY - 2003/12/9/pubmed PY - 2004/7/30/medline PY - 2003/12/9/entrez SP - 3917 EP - 34 JF - Electrophoresis JO - Electrophoresis VL - 24 IS - 22-23 N2 - This review represents a summary of recent progress in open-tubular capillary electrochromatography (OT-CEC) for chiral and achiral separations. The OT-CEC approach is an alternative to packed-CEC that could eliminate the problems associated with retaining frits and silica particles. In OT-CEC, the stationary phase is immobilized on the inner walls of the capillary. Preparation of the stationary phase is critical for OT-CEC. The preparation methods for capillary columns include (i) adsorption, (ii) covalent bonding and/or cross-linking, (iii) porous layers, (iv) chemical bonding after etching, (v) sol-gel, and (vi) molecular imprinting. Major developments, potential applications, technical difficulties and advantages associated with these wall coatings in OT-CEC are presented. In addition, the coupling of OT-CEC with mass spectrometry (MS) is briefly reviewed. Several applications of this hyphenated technique for analytical separations are also summarized. SN - 0173-0835 UR - https://www.unboundmedicine.com/medline/citation/14661227/Analytical_separations_in_open_tubular_capillary_electrochromatography_ DB - PRIME DP - Unbound Medicine ER -