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Hostile behaviors predict cardiovascular mortality among men enrolled in the Multiple Risk Factor Intervention Trial.
Circulation. 2004 Jan 06; 109(1):66-70.Circ

Abstract

BACKGROUND

Hostility is associated with incident coronary disease in most large population-based studies, but little is known about its association with cardiovascular disease (CVD) mortality in high-risk individuals. The aim of this study was to assess the association of hostility with CVD mortality in the subsequent 16 years in the Multiple Risk Factor Intervention Trial (MRFIT) participants and to explore the influence of hostility in the subset that had a nonfatal CVD event during the trial.

METHODS AND RESULTS

We coded the Structured Interview responses of 259 men who died of CVD during the 16 years of follow-up and 259 matching living control subjects. Signs of hostility were assessed by use of the Interpersonal Hostility Assessment Technique. Matching was based on center, intervention group, age, race, and interviewer; covariates included study entry diastolic blood pressure, cholesterol, smoking status, and nonfatal CVD event during the trial. High-hostile men were more likely to die of CVD than were low-hostile men. Adjusted odds ratio (OR) and 95% confidence intervals (CIs) were 1.61, 1.09 to 2.39. After the trial, high-hostile men who also had a nonfatal event during the trial were particularly likely to die of CVD, OR, 5.06, 1.42 to 8.22, compared with low-hostile men without a nonfatal event during the trial.

CONCLUSIONS

Hostility may be a risk factor for CVD mortality among high-risk men. Interventions aimed at anger management and stress reduction along with risk factor modification may be useful for hostile patients.

Authors+Show Affiliations

University of Pittsburgh, 3811 O'Hara St, Pittsburgh, Pa 15213, USA. matthewska@upmc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

14662707

Citation

Matthews, Karen A., et al. "Hostile Behaviors Predict Cardiovascular Mortality Among Men Enrolled in the Multiple Risk Factor Intervention Trial." Circulation, vol. 109, no. 1, 2004, pp. 66-70.
Matthews KA, Gump BB, Harris KF, et al. Hostile behaviors predict cardiovascular mortality among men enrolled in the Multiple Risk Factor Intervention Trial. Circulation. 2004;109(1):66-70.
Matthews, K. A., Gump, B. B., Harris, K. F., Haney, T. L., & Barefoot, J. C. (2004). Hostile behaviors predict cardiovascular mortality among men enrolled in the Multiple Risk Factor Intervention Trial. Circulation, 109(1), 66-70.
Matthews KA, et al. Hostile Behaviors Predict Cardiovascular Mortality Among Men Enrolled in the Multiple Risk Factor Intervention Trial. Circulation. 2004 Jan 6;109(1):66-70. PubMed PMID: 14662707.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hostile behaviors predict cardiovascular mortality among men enrolled in the Multiple Risk Factor Intervention Trial. AU - Matthews,Karen A, AU - Gump,Brooks B, AU - Harris,Kelly F, AU - Haney,Thomas L, AU - Barefoot,John C, Y1 - 2003/12/08/ PY - 2003/12/10/pubmed PY - 2004/12/16/medline PY - 2003/12/10/entrez SP - 66 EP - 70 JF - Circulation JO - Circulation VL - 109 IS - 1 N2 - BACKGROUND: Hostility is associated with incident coronary disease in most large population-based studies, but little is known about its association with cardiovascular disease (CVD) mortality in high-risk individuals. The aim of this study was to assess the association of hostility with CVD mortality in the subsequent 16 years in the Multiple Risk Factor Intervention Trial (MRFIT) participants and to explore the influence of hostility in the subset that had a nonfatal CVD event during the trial. METHODS AND RESULTS: We coded the Structured Interview responses of 259 men who died of CVD during the 16 years of follow-up and 259 matching living control subjects. Signs of hostility were assessed by use of the Interpersonal Hostility Assessment Technique. Matching was based on center, intervention group, age, race, and interviewer; covariates included study entry diastolic blood pressure, cholesterol, smoking status, and nonfatal CVD event during the trial. High-hostile men were more likely to die of CVD than were low-hostile men. Adjusted odds ratio (OR) and 95% confidence intervals (CIs) were 1.61, 1.09 to 2.39. After the trial, high-hostile men who also had a nonfatal event during the trial were particularly likely to die of CVD, OR, 5.06, 1.42 to 8.22, compared with low-hostile men without a nonfatal event during the trial. CONCLUSIONS: Hostility may be a risk factor for CVD mortality among high-risk men. Interventions aimed at anger management and stress reduction along with risk factor modification may be useful for hostile patients. SN - 1524-4539 UR - https://www.unboundmedicine.com/medline/citation/14662707/Hostile_behaviors_predict_cardiovascular_mortality_among_men_enrolled_in_the_Multiple_Risk_Factor_Intervention_Trial_ L2 - https://www.ahajournals.org/doi/10.1161/01.CIR.0000105766.33142.13?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -