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Hypolipidaemic effect of Casearia esculenta root extracts in streptozotocin-induced diabetic rats.
Pharmazie. 2003 Nov; 58(11):828-32.P

Abstract

The hypolipidaemic effect of an aqueous extract of Casearia esculenta root, an indigenous antidiabetic medicine popularly used in rural South India was investigated. Administration of the extract of C. esculenta (200 and 300 mg/kg body wt.) for 45 days resulted in significant reduction in serum and tissue cholesterol, phospholipids, free fatty acids and triglycerides in streptozotocin (STZ) diabetic rats. In addition to that, significant (p < 0.05) decrease in high density lipoprotein (HDL) whereas significant increase (p < 0.05) in low density lipoprotein (LDL) and very low density lipoprotein (VLDL) were observed in STZ diabetic rats, which was normalized after 45 days of C. esculenta root extract treatment. The root extract at dose of 300 mg/kg body wt. showed much significant hypolipidaemic effects than the dose of 200 mg/kg body weight.

Authors+Show Affiliations

Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar, Tamilnadu, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14664341

Citation

Prakasam, A, et al. "Hypolipidaemic Effect of Casearia Esculenta Root Extracts in Streptozotocin-induced Diabetic Rats." Die Pharmazie, vol. 58, no. 11, 2003, pp. 828-32.
Prakasam A, Sethupathy S, Pugalendi KV. Hypolipidaemic effect of Casearia esculenta root extracts in streptozotocin-induced diabetic rats. Pharmazie. 2003;58(11):828-32.
Prakasam, A., Sethupathy, S., & Pugalendi, K. V. (2003). Hypolipidaemic effect of Casearia esculenta root extracts in streptozotocin-induced diabetic rats. Die Pharmazie, 58(11), 828-32.
Prakasam A, Sethupathy S, Pugalendi KV. Hypolipidaemic Effect of Casearia Esculenta Root Extracts in Streptozotocin-induced Diabetic Rats. Pharmazie. 2003;58(11):828-32. PubMed PMID: 14664341.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypolipidaemic effect of Casearia esculenta root extracts in streptozotocin-induced diabetic rats. AU - Prakasam,A, AU - Sethupathy,S, AU - Pugalendi,K V, PY - 2003/12/11/pubmed PY - 2004/1/7/medline PY - 2003/12/11/entrez SP - 828 EP - 32 JF - Die Pharmazie JO - Pharmazie VL - 58 IS - 11 N2 - The hypolipidaemic effect of an aqueous extract of Casearia esculenta root, an indigenous antidiabetic medicine popularly used in rural South India was investigated. Administration of the extract of C. esculenta (200 and 300 mg/kg body wt.) for 45 days resulted in significant reduction in serum and tissue cholesterol, phospholipids, free fatty acids and triglycerides in streptozotocin (STZ) diabetic rats. In addition to that, significant (p < 0.05) decrease in high density lipoprotein (HDL) whereas significant increase (p < 0.05) in low density lipoprotein (LDL) and very low density lipoprotein (VLDL) were observed in STZ diabetic rats, which was normalized after 45 days of C. esculenta root extract treatment. The root extract at dose of 300 mg/kg body wt. showed much significant hypolipidaemic effects than the dose of 200 mg/kg body weight. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/14664341/Hypolipidaemic_effect_of_Casearia_esculenta_root_extracts_in_streptozotocin_induced_diabetic_rats_ L2 - https://medlineplus.gov/cholesterolmedicines.html DB - PRIME DP - Unbound Medicine ER -