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Influence of milk on the antimutagenic potential of green and black teas.
Anticancer Res. 2003 Sep-Oct; 23(5A):3863-7.AR

Abstract

BACKGROUND

The objective of this study was to evaluate whether addition of milk to green, black and decaffeinated black teas alters their antimutagenic activity.

MATERIALS AND METHODS

Two model mutagens were used, the direct-acting N'-methyl-N'-nitro-nitrosoguanidine (MNNG) and the indirect-acting 2-amino-3-methylimidazo-[4,5-flquinoline (IQ), and their mutagenic activity was determined in the Ames test, in the presence of tea and milk/tea mixtures. Solids from the milk/tea mixtures were removed by centrifugation and the supernatant analysed by HPLC for individual catechins and gallic acid in green tea, and thearubigins, theaflavins and flavonol glycosides in black teas.

RESULTS

Addition of skimmed milk to all the teas failed to influence their antimutagenic activity towards the two mutagens. Addition of milk to green tea resulted primarily in loss of (-)-epigallocatechin gallate whereas in the black teas it primarily reduced theaflavins levels.

CONCLUSION

The antimutagenic activity of green and black teas is not modulated by the presence of skimmed milk, even at high concentrations.

Authors+Show Affiliations

School of Biomedical and Life Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, U.K.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14666689

Citation

Catterall, Fenton, et al. "Influence of Milk On the Antimutagenic Potential of Green and Black Teas." Anticancer Research, vol. 23, no. 5A, 2003, pp. 3863-7.
Catterall F, Kassimi AI, Clifford MN, et al. Influence of milk on the antimutagenic potential of green and black teas. Anticancer Res. 2003;23(5A):3863-7.
Catterall, F., Kassimi, A. I., Clifford, M. N., & Ioannides, C. (2003). Influence of milk on the antimutagenic potential of green and black teas. Anticancer Research, 23(5A), 3863-7.
Catterall F, et al. Influence of Milk On the Antimutagenic Potential of Green and Black Teas. Anticancer Res. 2003 Sep-Oct;23(5A):3863-7. PubMed PMID: 14666689.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of milk on the antimutagenic potential of green and black teas. AU - Catterall,Fenton, AU - Kassimi,Avra I, AU - Clifford,Michael N, AU - Ioannides,Costas, PY - 2003/12/12/pubmed PY - 2004/2/12/medline PY - 2003/12/12/entrez SP - 3863 EP - 7 JF - Anticancer research JO - Anticancer Res VL - 23 IS - 5A N2 - BACKGROUND: The objective of this study was to evaluate whether addition of milk to green, black and decaffeinated black teas alters their antimutagenic activity. MATERIALS AND METHODS: Two model mutagens were used, the direct-acting N'-methyl-N'-nitro-nitrosoguanidine (MNNG) and the indirect-acting 2-amino-3-methylimidazo-[4,5-flquinoline (IQ), and their mutagenic activity was determined in the Ames test, in the presence of tea and milk/tea mixtures. Solids from the milk/tea mixtures were removed by centrifugation and the supernatant analysed by HPLC for individual catechins and gallic acid in green tea, and thearubigins, theaflavins and flavonol glycosides in black teas. RESULTS: Addition of skimmed milk to all the teas failed to influence their antimutagenic activity towards the two mutagens. Addition of milk to green tea resulted primarily in loss of (-)-epigallocatechin gallate whereas in the black teas it primarily reduced theaflavins levels. CONCLUSION: The antimutagenic activity of green and black teas is not modulated by the presence of skimmed milk, even at high concentrations. SN - 0250-7005 UR - https://www.unboundmedicine.com/medline/citation/14666689/Influence_of_milk_on_the_antimutagenic_potential_of_green_and_black_teas_ DB - PRIME DP - Unbound Medicine ER -